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Capping of conconavalin a receptors on lymphocytes of aged individuals and patients with Down’s syndrome: Enhancing effect of colchicine; possible relation to microtubular system

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Abstract

The redistribution of conconavalin A (Con A) receptors on peripheral blood mononuclear cells was studied in young adult patients with Down’s syndrome (DS), and young-adult controls and aged normal volunteers. DS was included in the study as it shows many features of accelerated aging. The percentage of Con A capping was markedly lower in DS patients and aged individuals than in young-adult controls. Colchicine displayed a significant enhancing effect on Con A capping in DS patients and aged individuals, but a moderate inhibitory effect on Con A capping in the young adults. The enhancing effect in DS patients and aged volunteers suggests the possibility that an excess of polymerized tubulin (microtubules) may occur in lymphocytes during normal or accelerated aging.

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Authors and Affiliations

  1. Department of Pathology, UCLA Center for the Health Sciences, Los Angeles, California, 90024

    F. Naeim, K. Bergmann & R. L. Walford

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  1. F. Naeim
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  2. K. Bergmann
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  3. R. L. Walford
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Naeim, F., Bergmann, K. & Walford, R.L. Capping of conconavalin a receptors on lymphocytes of aged individuals and patients with Down’s syndrome: Enhancing effect of colchicine; possible relation to microtubular system. AGE 4, 5–8 (1981). https://doi.org/10.1007/BF02432276

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