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Interaction of ceruloplasmin with the plasma membrane receptors of CV-1 cells and its feedback regulation

  • Genetics
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that cultured cells of the CV-1 line possess the capacity for high-affinity binding of ceruloplasmin, show a kinetics of saturation, and internalize ceruloplasmin. Propagation of cells in medium supplemented with fetal calf serum depleted of ceruloplasmin results in a two-fold increase of high-affinity receptor expression on the cell surface. This phenomenon is not accompanied by any change in the receptor-ligand affinity. Ceruloplasmin binding to the cell surface and subsequent internalization do not lead to its marked degradation.

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Authors and Affiliations

  1. Department of Molecular Genetics, Research Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg

    L. V. Puchkova, L. K. Sasina, T. D. Aleinikova & V. S. Gaitskhoki

Authors
  1. L. V. Puchkova
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  2. L. K. Sasina
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  3. T. D. Aleinikova
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  4. V. S. Gaitskhoki
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, No 4, pp. 417–420, April, 1995

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Puchkova, L.V., Sasina, L.K., Aleinikova, T.D. et al. Interaction of ceruloplasmin with the plasma membrane receptors of CV-1 cells and its feedback regulation. Bull Exp Biol Med 119, 404–407 (1995). https://doi.org/10.1007/BF02445905

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  • DOI: https://doi.org/10.1007/BF02445905

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