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Comparative analysis of effects from prolonged peripheral and intracerebral exposure to β-endorphin

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

During a long-term (7-day) continuous exposure of rats to β-endorphin from an implanted minipump by the subcutaneous route, changes in their motor activity (stereotypy) and pain sensitivity (hypoalgesia) were similar, though less marked, than those observed during such exposure by the intracerebral route, whereas the change in feeding behavior with the subcutaneous (peripheral) route of β-endorphin administration (hyperphagia) was opposite to that seen with intracerebral administration (hypophagia).

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Authors and Affiliations

  1. P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow

    S. M. Tolpygo & E. I. Pevtsova

Authors
  1. S. M. Tolpygo
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  2. E. I. Pevtsova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, Nno 11, pp. 457–460, November, 1995

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Tolpygo, S.M., Pevtsova, E.I. Comparative analysis of effects from prolonged peripheral and intracerebral exposure to β-endorphin. Bull Exp Biol Med 120, 1079–1082 (1995). https://doi.org/10.1007/BF02445469

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  • DOI: https://doi.org/10.1007/BF02445469

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