Abstract
The hormone of melatonin is the main regulator of biological rhythms. It was first found in the pineal gland in 1958. Melatonin is involved in the regulation of many vital physiological processes: maturation and development of genitalias, metabolism of pigments and free radicals, immune response, mood and sleep, and cell proliferation and differentiation. The pineal gland is not the only organ synthesizing melatonin. Extrapineal melatonin is widely dis-tributed in humans and animals. Melatonin-producing cells are found in the gastrointestinal and respiratory tracts, pancreas, adrenal and thyroid glands, thymus, cerebellum, urogenital system, placenta, and other organs. Melatonin is intensely synthesized in non-endocrine cells: mast cells, natural killers, eosinophilic leukocytes, platelets, and endotheliocytes. Such a wide distribution of melatonin reflects its key role as an intercellular neuroendocrine regulator and coordinator of many complex and interrelated biological processes.
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References
I. M. Kvetnoi,Uspekhi Fiziol. Nauk,18, 84–102 (1987).
I. M. Kvetnoi, T. V. Kvetnaya, A. G. Konoplyannikov,et al., Melatonin: Biological and Oncoradiological Aspects [in Russian], Obninsk, 17–23 (1994).
I. M. Kvetnoi, N. T. Raikhlin, and T. M. Solomatina,Sov. Med., No. 7, 53–59 (1983).
M. A. Osadchuk, V. F. Kirichuk, and I. M. Kvetnoi,Diffuse Neuroendocrine System [in Russian], Saratov (1996).
N. T. Raikhlin and I. M. Kvetnoi,Byull. Eksp. Biol. Med.,78, No. 8, 114–116 (1974).
N. T. Raikhlin, I. M. Kvetnoi, S. A. Blinova,et al., Melatonin: Biological and Oncoradiological Aspects [in Russian], Obninsk, 9–16 (1994).
N. T. Raikhlin, I. M. Kvetnoi, G. M. Deinenko,Eksp. Onkol.,4, 10–16 (1983).
N. T. Raikhlin, I. M. Kvetnoi, and M. A. Osadchuk,APUD System (Biological and Oncoradiological Aspects) [in Russian], Obninsk (1993).
V. V. Yuzhakov, I. M. Kvetnoi, and G. A. Petrova,Byull. Eksp. Biol. Med.,110, No. 10, 438–440 (1990).
A. Andrew,Br. Med. Bull.,38, 221–225 (1982).
J. Arendt,Advances in Pineal Research (London),8, 439–441 (1994).
J. Axelrod and H. Weissbach,Science,131, 1312–1318 (1960).
S. Banerjee and L. Margulis,Exp. Cell Res.,78, 314–318 (1973).
R. Barter and A. G. E. Pearse,J. Pathol. Bacteriol.,17, 373–384 (1993).
C. Bartsch, I. M. Kvetnoy, T. V. Kvetnaia,et al., J. Pineal. Res.,23, 90–96 (1997).
G. A. Bubenik,Horm. Res.,6, 313–323 (1980).
G. A. Bubenik, G. M. Brown, and L. J. Grota,J. Histochem. Cytochem.,24, 1173–1177 (1976).
G. A. Bubenik, R. Purtill, and G. M. Brown,Exp. Eye Res.,27, 323–333 (1978).
A. Costa, A. Poma, P. Navarra,et al., J. Endocrinol.,149, 199–207 (1996).
T. M. Dawson and V. L. Dawson,Annu. Rev. Med.,47, 219–227 (1996).
V. Erspamer and B. Asero,Nature,169, 800–801 (1952).
F. Feyrter,Uber Diffuse Endokrine Epitheliale Organ, Leipzig (1938).
L. J. Grota and G. M. Brown,Can. J. Biochem.,52, 196–203 (1974).
R. Heidenghain,Pflugers Arch.,43, Suppl. 2B, 1–103 (1888).
M. Hermes-Lima, R. F. Castillo, V. G. R. Valle,et al., Biochim. Biophys. Acta,1189, 201–206 (1992).
G. Huether,Experientia,49, 1–6 (1993).
N. Kaul, N. Siveski-Iliskovic, M. Hill,et al., J. Pharmacol. Toxicol. Methods,30, No. 2,55–67 (1993).
D. J. Kennaway, R. G. Frith, G. Phillipou,et al., Endocrinology,110, 2186–2194 (1977).
F. L. Kiechle and T. Malinski,Am. J. Clin. Pathol.,100, No. 5, 567–575 (1993).
D. N. Krause and M. L. Dubocovich,Annu. Rev. Pharmacol. Toxicol.,31, 549–568 (1991).
N. K. Kultschitzky,Arch. Mikroscop. Anat. Forsch.,49, 7–16 (1898).
I. M. Kvetnoy, C. Bartsch, H. Bartsch,et al., Acta Histochem. Cytochem.,29, 304–305 (1996).
I. M. Kvetnoy, A. K. Sandvik, and H. L. Waldum,J. Mol. Endocrinol.,18, 1–3 (1997).
I. M. Kvetnoy and V. V. Yuzhakov,Microsc. Anal.,21, 27–29 (1993).
I. M. Kvetnoy and V. V. Yuzhakov,Advances in Pineal Research,7, 199–212 (1994).
I. M. Kvetnoy and V. V. Yuzhakov,Proc. R. Microsc. Soc.,30, No. 2, 123–124 (1995).
I. M. Kvetnoy, V. V. Yuzhakov, and N. T. Raikhlin,Microsc. Anal.,48, 25–27 (1997).
I. M. Kvetnoy, V. V. Yuzhakov, and A. F. Tsyb,Pathol. Res. Pract.,191, No. 7-8, 705–706 (1995).
L.-I. Larsson,Invest. Cell Pathol.,3, 73–85 (1980).
A. Lerner, J. Case, and J. Takahashi,J. Am. Chem. Soc.,81, 6084–6086 (1958).
G. Maestroni and A. Conti,Advances in Pineal Research,4, 233–241 (1990).
A. Menendez-Pelaez and R. J. Reiter,J. Pineal Res.,15, 59–69 (1993).
Y. Ozaki and H. Lynch,Endocrinology,99, 641–644 (1976).
A. G. E. Pearse,J. Histochem. Cytochem.,17, 303–313 (1969).
J. M. Polak and S. R. Bloom,Immunocytochemistry: Modern Methods and Applications, Bristol, 328–348 (1986).
W. B. Quay and Y. H. Ma,Ir. J. Med. Sci.,4, 563 (1976).
N. T. Raikhlin and I. M. Kvetnoy,Acta Histochem.,55, 19–25 (1976).
N. T. Raikhlin and I. M. Kvetnoy,Physiol. Gen. Biol. Rev.,8, No. 4, 1–44 (1994).
N. T. Raikhlin, I. M. Kvetnoy, and Z. M. Kadagidze,Acta Histochem.,11, 75–77 (1978).
N. T. Raikhlin, I. M. Kvetnoy, and V. N. Tolkachev,Nature,155, 344–345 (1975).
R. J. Reiter,Endocr. Rev.,1, 109–131 (1980).
R. J. Reiter,News Physiol. Sci.,6, 223–228 (1991).
R. J. Reiter, B. Poeggeler, D. X. Tan,et al., Neuroendocrinol. Lett.,15, No. 1-2, 103–116 (1993).
R. J. Reiter, D. X. Tan, B. Poeggeler,et al., Advances in Pineal Research,7, 211–228 (1994).
S. M. Sagar, G. Singh, I. Hodson,et al., Cancer Treat. Rev.,21, 159–181 (1995).
E. Solcia, L. Usellini, R. Buffa,et al., Regulatory Peptides, Basel, 220–246 (1989).
F. Sundler, G. Bottcher, E. Ekblad, and R. Hakanson,Acta Oncol.,283, 303–314 (1989).
J. Vanecek and L. Vollrath,Advances in Pineal Research,4, 147–154 (1990).
A. A. J. Verhofstad, H. W. M. Steinbusch, H. W. J. Joosten,et al., Immunocytochemistry. Practical Applications in Biology and Pathology, Bristol, 143–168 (1983).
M. Vialli,5-Hydroxytryptamine and Related Indolealkylamines: Handbook of Experimental Pharmacology, Berlin.19, 1–65 (1966).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 4, pp. 364–730, April, 1999
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Kvetnoii, I.M., Raikhlin, N.T., Yuzhakov, V.V. et al. Extrapineal melatonin and its role in the neuroendocrine regulation of homeostasis. Bull Exp Biol Med 127, 329–334 (1999). https://doi.org/10.1007/BF02433372
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DOI: https://doi.org/10.1007/BF02433372