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Quantitative analysis of the role of cholinergic, gastrin, and histamine regulatory mechanisms of pepsinogen production in the stomach of narcotized rats

  • Physiology
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Abstract

Pepsinogen secretion in the intraluminally perfused stomach of narcotized rats was induced by electrical stimulation of the vagus nerve or intravenous injection of pentagastrin. Blockade of histamine H2 receptors inhibited pepsinogen production induced by vagal stimulation by 35%, but caused only a 13% decrease in pentagastrin-stimulated pepsinogen secretion.

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Authors and Affiliations

  1. Laboratory of Physiology of Digestion, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg

    R. P. Khropycheva, V. A. Zolotarev & S. A. Polenov

Authors
  1. R. P. Khropycheva
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  2. V. A. Zolotarev
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  3. S. A. Polenov
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Corresponding author

Correspondence to S. A. Polenov.

Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 1, pp. 12–15, January, 2000

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Khropycheva, R.P., Zolotarev, V.A. & Polenov, S.A. Quantitative analysis of the role of cholinergic, gastrin, and histamine regulatory mechanisms of pepsinogen production in the stomach of narcotized rats. Bull Exp Biol Med 129, 7–9 (2000). https://doi.org/10.1007/BF02433853

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  • DOI: https://doi.org/10.1007/BF02433853

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