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Activation of rat mast cells upon stimulation of protease-activated receptor (PAR-1)

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

In vivo experiments on the model of wound healing showed that thrombin and thrombin receptor agonist TRAP-6 stimulated heparin secretion by mast cells in rat subcutaneous fat: the saturation of mast cells with heparin decreased, while degranulation and granulolysis increased.In vitro studies showed that TRAP-6 caused a dose-dependent release of β-hexosaminidase from peritoneal mast cells. TRAP-6 also induced heparin release from these cells and inhibition of amidase activity of thrombin. Heparin released from mast cells had low anticoagulant activity. These data suggest that activation of mast cells with thrombin is mediated by PAR-1.

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References

  1. D. P. Lindner, N. A. Poberii, M. Ya. Rozkin,et al., Arkh. Pat., No. 6, 60–66 (1980).

    Google Scholar 

  2. A. I. Strukov, S. M. Strukova, T. G. Khlebnikova,et al., Byull. Eksp. Biol. Med.,93, No. 6, 116–120 (1982).

    Article  CAS  Google Scholar 

  3. S. M. Strukova, E. G. Kireeva, and T. N. Dugina,Vestn. Mosk. Univ. Ser. 16, No. 1, 8–16 (1997).

    Google Scholar 

  4. B. A. Umarova, S. V. Khlgatyan, and S. M. Strukova,Byull. Eksp. Biol. Med.,108, No. 2, 131–133 (1989).

    Google Scholar 

  5. L. Brass,Coron. Artery Dis.,8, 49–58 (1997).

    PubMed  CAS  Google Scholar 

  6. G. Cirino, C. Cicala, M. R. Bucci,et al., J. Exp. Med.,183, 821–827 (1996).

    Article  PubMed  CAS  Google Scholar 

  7. J. W. Fenton II,Thromb. Haemost.,74, 493–498 (1995).

    PubMed  CAS  Google Scholar 

  8. E. Glusa and M. Paintz,Naunyn Schmiedebergs Arch. Pharmacol.,349, 431–436 (1994).

    PubMed  CAS  Google Scholar 

  9. A. A. Horner,Biochem. J.,240, 171–179 (1986).

    PubMed  CAS  Google Scholar 

  10. G. Pejler and A. Karlstrom,J. Biol. Chem.,268, 11817–11822 (1993).

    PubMed  CAS  Google Scholar 

  11. E. Rasin and G. Marx,J. Immunol.,133, 3282–3285 (1984).

    Google Scholar 

  12. D. Salvemini, E. Masini, E. Anggard,et al., Biochem. Biophys. Res. Commun.,169, 586–601 (1990).

    Article  Google Scholar 

  13. B. Schick and K. F. Austen,Immunology,66, 434–438 (1989).

    PubMed  CAS  Google Scholar 

  14. T.-K. Vu, D. Hung, V. Wheaton, and S. Coughlin,Cell,64, 1057–1068 (1991).

    Article  PubMed  CAS  Google Scholar 

  15. R. Warren and A. Wysocki,Surgery,44, 435–441 (1958).

    PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Human and Animal Physiology, M. V. Lomonosov Moscow State University, Moscow, USSR

    B. A. Umarova, T. N. Dugina, E. V. Shestakova & S. M. Strukova

  2. Center of Vascular Surgery and Medicine, F. Schiller Jena University, Erfurt, Germany

    E. Gluza

Authors
  1. B. A. Umarova
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  2. T. N. Dugina
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  3. E. V. Shestakova
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  4. E. Gluza
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  5. S. M. Strukova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 370–373, April, 2000

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Umarova, B.A., Dugina, T.N., Shestakova, E.V. et al. Activation of rat mast cells upon stimulation of protease-activated receptor (PAR-1). Bull Exp Biol Med 129, 314–317 (2000). https://doi.org/10.1007/BF02439253

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  • DOI: https://doi.org/10.1007/BF02439253

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