Abstract
Hyperthermia caused hemodynamic disorders in the liver and degenerative and necrobiotic changes in hepatocytes of CBA mice. Total hepatocyte count decreased during restitution, this decrease being most pronounced 30 min after exposure. The number of binucleated cells also markedly decreased. The absence of necrotic changes in hepatocytes during the entire restitution period indicated their apoptotic death and elimination by macrophagal resorption. Under these conditions liver regeneration at the cellular level occured mainly via division of binucleated hepatocytes. On the other hand, proliferation of oval cells in the portal zones and their differentiation into hepatocytes were observed at certain stages of reparative regeneration of the liver.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 9, pp. 346–350, September, 2000
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Molodykh, O.P., Nepomnyashchikh, L.M., Lushnikova, E.L. et al. Apoptosis: Decrease of hepatocyte population in mice after hyperthermia. Bull Exp Biol Med 130, 912–916 (2000). https://doi.org/10.1023/A:1015390901689
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DOI: https://doi.org/10.1023/A:1015390901689