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Lipoprotein lipase as humoral agent of the physiological anticlotting system

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Summary

Experiments were staged on 450 male albino rats. As established, a stable food lipemia was attained after keeping the animals on a fat diet (according to Wilgram [42,43]) for 8 months. The activity of lipoprotein plasma lipase in such animals was half as compared to control animals which were given the usual laboratory ration. Intravenous injection of heparin led to considerable activation of lipoprotein lipase in experimental animals. However, it did not reach the level attained in control animals after injection of the same doses of heparin. Intravenous injection of thrombin to normal animals led to activation of lipoprotein lipase due to the appearance in the blood of some excess of reflex-secreten heparin by the physiological anticoagulating system [4, 7, 10] in response to the appearance of thrombin in the circulation.

Thus, the development of prethrombotic state in animals kept on a fat diet was accompanied by reduction of lipoprotein lipase activity due to deficiency of heparin and partially of the enzyme itself. A conclusion was drawn that lipoprotein lipase was connected with the function of the physiological anticoagulating system.

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Literature Cited

  1. G. G. Bazaz'yan, N. P. Sytina, G. V. Andreenko, et al. Byull. éksper. biol., 10, 26 (1961).

    Google Scholar 

  2. T. M. Kalishevskaya, B. I. Kotlyar, and B. A. Kudryashov, Byull. éksper. biol., 7, 5 (1961).

    Google Scholar 

  3. B. A. Kudryashov and P. D. Ulytina, Nature 1958, Vol. 182, p. 397.

    Google Scholar 

  4. B. A. Kudryashov, Nature, 1959, Vol. 184, p. 454.

    Google Scholar 

  5. B. A. Kudryashov, Vopr. med. khimiii, 1, 3 (1960).

    Google Scholar 

  6. B. A. Kudryashov, Kardiologiya, 5, 7 (1961).

    Google Scholar 

  7. B. A. Kudryashov. Kardiologiya, 5, 7 (1961).

    Google Scholar 

  8. B. A. Kudryashov, G. V. Andreenko, G. G. Bazaz'yan, et al., Klin. med., 3, 19 (1961).

    Google Scholar 

  9. B. A. Kudryashov, G. V. Andreenko, G. G. Bazaz'yan, et al., Vestn. Moskovsk. Univ. Seriya 6. Biologiya, pochvovedenie, 2, 3 (1961).

    Google Scholar 

  10. B. A. Kudryashov. In the book: Abstracts of Sectional Proceedings of the 5th International Biochemical Congress [in Russian], Vol. 2, p. 175. Moscow, 1961.

  11. B. A. Kudryashov, Thrombos. Diather. Haemorrh (Stuttg), 1961, Bd. 6, S. 371.

    Google Scholar 

  12. B. A. Kudryashov, G. G. Bazaz'yan, N. P. Sytina, et al., Nature, 1961, Vol. 189, p. 67.

    Google Scholar 

  13. B. A. Kudryashov and G. G. Bazaz'yan. In the book: Proceedings of the 14th Conference of Physiologists of the Southern RSFSR [in Russian], p. 161. Krasnodar, 1962.

  14. F. Bidwell citing B.Biggs and R.G.MacFarlane, Human Blood Coagulation and its Disorders, Oxford, 1953.

  15. B. Borgström, Acta physiol. scand., 1952, Vol. 25, p. 328.

    Google Scholar 

  16. J. H. Bragdon, J. Lab. clin. Med., 1958, Vol. 52, p. 564.

    Google Scholar 

  17. M. Buckell and F. A. Elliott, Lancet, 1959, Vol. 1, p. 662.

    Google Scholar 

  18. H. B. Eiber and I. Danishefsky Nature, 1957, Vol. 180, p. 1359.

    Google Scholar 

  19. H. Engelberg, J. Biol. Chem., 1956, Vol. 222, p. 601.

    Google Scholar 

  20. H. Engelberg, Proc. Soc. exp. Biol. (N. Y.), 1958, Vol. 97, p. 304.

    Google Scholar 

  21. J. W. Farquhar, T. C. Merigan, and M. Sokolow, J. exp. Med., 1961, Vol. 113, p. 587.

    Google Scholar 

  22. V. Felt and D. Reichl, Lancet, 1957, Vol. 1, p. 664.

    Google Scholar 

  23. Th. Gillman and S. S. Naidoo, Nature, 1957, Vol. 179, p. 904.

    Google Scholar 

  24. J. Gormsen, Brit. J. Haemat., 1959, Vol. 5, p. 257.

    Google Scholar 

  25. H. B. W. Greig, Lancet, 1956, Vol. 2, p. 16.

    Google Scholar 

  26. H. B. W. Greig and I. A. Runde, Lancet, 1957, Vol. 2, p. 461.

    Google Scholar 

  27. H. B. W. Greig, Thrombolytic Activity and Related Phenomena, 1960, p. 252.

  28. A. Grigant, C. R. Soc. Biol., 1910, Vol. 68, p. 827.

    Google Scholar 

  29. M. I. Grossman, J. Stadler, A. Cushing, et al., Proc. Soc. exp. Biol. (N. Y.), 1955, Vol. 88, p. 132.

    Google Scholar 

  30. M. I. Grossman, L. Palm, G. H. Becker, et al., Proc. Soc. exp. Biol. (N. Y.), 1954, Vol. 87, p. 312.

    Google Scholar 

  31. P. F. Hahn, Science, 1943, Vol. 98, p. 19.

    Google Scholar 

  32. S. N. Jagannathan and C. Gopalan, Indian J. med. Res., 1960, Vol. 48, p. 756.

    Google Scholar 

  33. K. J. Kingsbury and D. M. Morgan, Clin. Sci., 1957, Vol. 16, p. 589.

    Google Scholar 

  34. E. D. Korn, Science, 1954, Vol. 120, p. 399.

    Google Scholar 

  35. E. D. Korn, J. biol. Chem., 1957, Vol. 226 p. 827.

    Google Scholar 

  36. W. Logemann, Naturwissenschaften, 1957, Bd. 44, S. 423.

    Google Scholar 

  37. G. A. McDonald and H. W. Fullerton, Lancet, 1958, Vol. 2, p. 600.

    Google Scholar 

  38. L. O. Pilgeram and D. M. Greenberg, Science, 1954, Vol. 120, p. 760.

    Google Scholar 

  39. L. O. Pilgeram and L. C. Rose, Circulation, 1956, Vol. 14, p. 502.

    Google Scholar 

  40. L. O. Pilgeram and A. T. Tu, J. appl. Physiol., 1957, Vol. 11, p. 450.

    Google Scholar 

  41. D. S. Robinson and J. C. F. Poole, Quart. J. exp., Physiol, 1956, Vol. 41, p. 36.

    Google Scholar 

  42. R. F. Scott, K. Alousi, F. Goodale, et al., Arch. Path., 1961, Vol. 71, p. 714.

    Google Scholar 

  43. G. F. Wilgram, Proc. Soc exp. Biol. (N. Y.), 1958, Vol. 99, p. 496.

    Google Scholar 

  44. G. F. Wilgram, J. exp. Med., 1959, Vol. 109, p. 293.

    Google Scholar 

  45. LeRoy et al., J. Lab. clin. Med., 1950, Vol. 35, No. 3, p. 446.

    Google Scholar 

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Authors and Affiliations

  1. Laboratory of the Physiology and Biochemistry of Blood Clotting, M. V. Lomonosov Moscow State University, Moscow, USSR

    B. A. Kudryashov, G. G. Bazaz'yan, S. S. Trapeznikova & V. N. Nosova

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  1. B. A. Kudryashov
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  2. G. G. Bazaz'yan
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  3. S. S. Trapeznikova
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  4. V. N. Nosova
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Kudryashov, B.A., Bazaz'yan, G.G., Trapeznikova, S.S. et al. Lipoprotein lipase as humoral agent of the physiological anticlotting system. Bull Exp Biol Med 55, 493–496 (1964). https://doi.org/10.1007/BF00784399

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  • DOI: https://doi.org/10.1007/BF00784399

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