Abstract
Basal forebrain regions were transplanted from mouse embryos with chromosome 16 trisomy into the lateral brain ventricle of healthy adult mice. After 1–12 months, the grafts contained immunoreactive choline- and GABAergic neurons and astroglial cells. Quantitative analysis revealed no neurodegenerative changes in these grafts compared to diploid ones. Pronounced infiltration with T and B cells and activation of micro- and astroglia were found in the grafts with chromosome 16 trisomy and in control specimen.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 128, No. 11, pp. 559–564, November, 1999
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Lushchekina, E.A., Schtal', T., Shlibs, R. et al. Can neurografts from mice with chromosome 16 trisomy serve as a model of Alzheimer disease?. Bull Exp Biol Med 128, 1145–1149 (1999). https://doi.org/10.1007/BF02433424
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DOI: https://doi.org/10.1007/BF02433424