Abstract
The labeling index (incubation with thymidine-H3) and the volume doubling time (repeated roentgenography) were compared for three human lung tumors: two squamous-cell carcinomas with different levels of differentiation, and one hamartoma. The minimal doubling time (178 days) was found for the squamous-cell carcinoma with a lower level of differentiation and with the highest labeling index (19.0%). The hamartoma (a benign lung tumor) had the longest doubling time (1250 days) and the smallest labeling index (3.8%).
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Literature Cited
M. S. Aksyutina, L. P. Lipchina, and L. Ya. Yablonovskaya, Tsitologiya,12, No. 4, 483 (1970).
N. M. Émanuél', L. S. Evseenko, N. P. Korman, et al., in: Progress in Science and Technology. General Oncology, 1968 [in Russian], Moscow (1969), pp. 7–41.
N. M. Émanuél' and L. S. Evseenko, Quantitative Bases of Clinical Oncology [in Russian], Moscow (1970).
E. Hirai, T. Tobe, H. Niibe, et al., Nippon Acta Radiol.,28, 485 (1968).
E. P. Malaise, N. Chavaudra, and M. Tubiana, Europ. J. Cancer,9, 305 (1973).
G. G. Steel, Europ. J. Cancer,3, 381 (1967).
G. G. Steel, Cell Tissue Kinet.,5, 87 (1972).
G. G. Steel and J. P. Bensted, Europ. J. Cancer,1, 275 (1965).
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Krutova, T.V., Korman, D.B., Aksyutina, M.S. et al. Correlation between doubling time of volume of human lung tumors and labeling index. Bull Exp Biol Med 81, 73–75 (1976). https://doi.org/10.1007/BF00800172
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DOI: https://doi.org/10.1007/BF00800172