Abstract
In experiments on dogs a single injection of insulin in a dose of 1 unit/kg body weight caused an increase in the maximal reabsorption of glucose and secretion of diodone and reduced the excretion of sodium without any change in glomerular filtration. These effects depend on the direct action of insulin, for when it was injected directly into one of the renal arteries its action was manifested only in the kidney on the side of infusion. Prednisolone had no significant effect on glucose and diodone transport when given as a single injection (3–4 mg/kg) or over a period of 10 days (1.5–2 mg/kg daily).
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Bryukhanov, V.M., Nikitin, A.I. Effect of insulin and prednisolone on transport of organic substances in the dog kidney. Bull Exp Biol Med 86, 1621–1624 (1978). https://doi.org/10.1007/BF00801820
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DOI: https://doi.org/10.1007/BF00801820