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Action of naloxone on emotionally positive and antinociceptive effects of hypothalamic stimulation in rats

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Naloxone (5 mg/kg, subcutaneously) had no significant effect on the electrical self-stimulation response in rats with electrodes in the lateral hypothalamus. An analgesic effect of stimulation of the “reward” zones was found in three animals, in the form of raising of the threshold of pain vocalization during electrical stimulation of the tail. The antinociceptive action was abolished by naloxone. Morphine (3 mg/kg) activated the self-stimulation response, whereas naloxone antagonized this action. The role of opiate receptors in self-stimulation effects and in central analgesia is discussed.

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Authors
  1. E. E. Zvartau
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Zvartau, E.E. Action of naloxone on emotionally positive and antinociceptive effects of hypothalamic stimulation in rats. Bull Exp Biol Med 88, 1306–1309 (1979). https://doi.org/10.1007/BF00835580

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  • DOI: https://doi.org/10.1007/BF00835580

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