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Habituation of Activity in an Open Field: A Survey of Inbred Strains and F1 Hybrids

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Abstract

To determine if there is genetic variability in habituation of activity in an open field, we examined a number of inbred strains and F1 hybrids. Using 5-min exposures to a dark open field, we measured changes in exploratory behavior over 3 consecutive days in 129S3/SvImJ, A/J, BALB/ cByJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/2J, FVB/NJ, (B6 × 129)F1/J, and (B6 × C3H) F1/J male and female mice. Strain differences in open-field activity and in habituation were evident. Some of the strain differences were further modified by sex. The strains and F1's could be separated into groups that increased, decreased, or did not modify their activities across testing sessions. In a second study, the effects of altering the floor surface on habituation were examined in male 129S3/SvImJ, C57BL/6J, DBA/2J, and (B6 × 129)F1/J mice. When the floor was altered after 3 consecutive days of habituation, increased activity levels were evident. There were strain differences in the responsiveness to the changes in the floor. These results confirm a genetic role in intersession habituation to an open field.

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Authors and Affiliations

  1. Genomics Institute, Wadsworth Center, Albany, New York, 12201-2002

    Valerie J. Bolivar, Barbara J. Caldarone & Lorraine Flaherty

  2. Department of Biomedical Sciences, University at Albany, Albany, New York, 12201-0509

    Valerie J. Bolivar & Barbara J. Caldarone

  3. Department of Psychology, University at Albany, Albany, New York, 12222

    Barbara J. Caldarone

  4. Laboratory of Structural Pathology, Wadsworth Center, Albany, New York, 12201-2002

    Andrew A. Reilly

  5. Department of Biometry and Statistics, University at Albany, Albany, New York, 12201-0509

    Andrew A. Reilly

  6. Department of Biomedical Sciences, University at Albany, Albany, New York, 12201-0509

    Lorraine Flaherty

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Bolivar, V.J., Caldarone, B.J., Reilly, A.A. et al. Habituation of Activity in an Open Field: A Survey of Inbred Strains and F1 Hybrids. Behav Genet 30, 285–293 (2000). https://doi.org/10.1023/A:1026545316455

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