Abstract
Two polymorphic esterase systems were found after electrophoresis of rabbit tissue homogenates. Each of these systems is controlled by an autosomal locus with two alleles. Est-4 determines the absence (Est-4a) or presence (Est-4b) of two bands of esterase activity with intermediate anodal mobility and broad substrate specificity. This polymorphism was found to be present in liver, small intestine, and spleen but not in kidney, heart, and testis. Est-5 is coding for cathodally migrating esterases which differ in mobility (Est-5a and Est-5b). This polymorphism was found only in kidney and testis homogenates. Est-5 esterases are more active against α-naphthyl acetate than against β-naphthyl acetate and have no activity against α-naphthyl butyrate. Linkage analysis indicated that Est-4 is localized on rabbit LG VI as part of a cluster of esterase loci, whereas Est-5 segregates independently. Rabbits from two inbred and nine partly inbred strains were tested for these polymorphisms.
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This investigation was supported in part by Public Health Service Research Grant RR-00251 from the Division of Research Resources and by funds from the University of Utrecht. The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care.
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van Zutphen, L.F.M., Fox, R.R. & den Bieman, M.G.C.W. Genetics of two tissue esterase polymorphisms (Est-4 and Est-5) in the rabbit. Biochem Genet 21, 773–780 (1983). https://doi.org/10.1007/BF00498923
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DOI: https://doi.org/10.1007/BF00498923