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Polyadenylic–Polyuridylic Acid Plus Locoregional Radiotherapy Versus Chemotherapy with CMF in Operable Breast Cancer: a 14 Year Follow-up Analysis of a Randomized Trial of the Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC)

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Abstract

With a median follow-up of 14 years, the combination of polyadenylic–polyuridylic acid plus locoregional radiotherapy (257 patients) has significantly improved disease-free survival (p = 0.03) and significantly reduced the incidence of metastases (p = 0.04) when compared to CMF alone (260 patients), in women with operable breast cancer. The trial does not, however, permit an appreciation of the respective role of radiotherapy and PolyAU in these results.

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References

  1. Lacour J, Laplanche A, Delozier T, Berlie J, Mourali N, Julien JP, De Gislain C, Namer N, Petit JC, Denis V, Luboinski M: Polyadenylic-polyuridylic acid plus locoregional and pelvic radiotherapy versus chemotherapy with CMF as adjuvants in operable breast cancer. A 6\(\frac{1}{2}\)-year follow-up analysis of a randomized trial of the French federation of Cancer Centers. Breast Cancer Res Treat 19: 15–21, 1991

    PubMed  Google Scholar 

  2. Overgaard M, Jensen MB, Overgaard J, Hansen PS, Rose C, Andersson M, Kamby C, Kjaer M, Gadeberg CC, Rasmussen BB, Blichert-Toft M, Mouridsen HT: Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 353: 1641–1648, 1999

    PubMed  Google Scholar 

  3. Overgaard M: Overview of randomized trials in high risk breast cancer patients treated with adjuvant systemic therapy with or without postmastectomy irradiation. Semin Radiat Oncol 9: 292–299, 1999

    PubMed  Google Scholar 

  4. Early Breast Cancer Trialists' Collaborative Group: Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Lancet 355: 1757–1770, 2000

    Google Scholar 

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Authors and Affiliations

  1. Département de Biostatistique et d'Epidémiologie, Institut Gustave-Roussy, Villejuif, France

    A. Laplanche, L. Alzieu & M. Luboinski

  2. Service d'oncologie médicale, Centre François Baclesse, Caen, France

    T. Delozier

  3. Statistique et Information Médicale, Centre René Huguenin, Saint-Cloud, France

    J. Berlie

  4. Service Oncologie, Centre Henri Becquerel, Rouen, France

    C. Veyret

  5. Service Oncologie, Centre Georges François Leclerc, Dijon, France

    P. Fargeot

  6. Département de Chirurgie, Institut Gustave Roussy, Villejuif, France

    J. Lacour

Authors
  1. A. Laplanche
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  2. L. Alzieu
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  3. T. Delozier
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  4. J. Berlie
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  5. C. Veyret
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  6. P. Fargeot
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  7. M. Luboinski
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  8. J. Lacour
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Laplanche, A., Alzieu, L., Delozier, T. et al. Polyadenylic–Polyuridylic Acid Plus Locoregional Radiotherapy Versus Chemotherapy with CMF in Operable Breast Cancer: a 14 Year Follow-up Analysis of a Randomized Trial of the Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC). Breast Cancer Res Treat 64, 189–191 (2000). https://doi.org/10.1023/A:1006498121628

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  • DOI: https://doi.org/10.1023/A:1006498121628

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