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Serum albumin

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Abstract

The large mass of data that has been collected demonstrates that albumin distribution has a fairly constant ratio in many disease states, and that the extravascular pool appears to maintain the intravascular content by supplying albumin. The distribution of extravascular albumin may play some role in osmotic regulation of albumin synthesis. The skin is the major source of extravascular albumin. Factors influencing albumin production are state of health, environment, nutrition, hormonal balance, and osmotic equilibrium. Of these, the nutritional status is probably the most important. Sites of degradation of albumin are unknown. Stress and some hormones appear to enhance degradation. Metabolism of another protein does not affect albumin degradation, and albumin degradation and synthesis are not interdependent.

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Authors and Affiliations

  1. From the Radioisotope Service, Department of Medicine, Veterans Administration Hospital, USA

    M. A. Rothschild MD, M. Oratz PhD & S. S. Schreiber MD

  2. the Department of Biochemistry, New York University College of Dentistry, USA

    M. A. Rothschild MD, M. Oratz PhD & S. S. Schreiber MD

  3. the Department of Medicine, New York University School of Medicine, 10016, New York, NY

    M. A. Rothschild MD, M. Oratz PhD & S. S. Schreiber MD

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  3. S. S. Schreiber MD
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Supported in part by NIH Grant AM-02489 and PHS Grant HE-09562-05.

The authors wish to acknowledge the secretarial assistance of Miss Judith Rosenblum in preparation of this manuscript.

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Rothschild, M.A., Oratz, M. & Schreiber, S.S. Serum albumin. Digest Dis Sci 14, 711–744 (1969). https://doi.org/10.1007/BF02233577

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