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Clinical conditions associated with columnar lined esophagus

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Abstract

Three case reports are presented which illustrate clinical conditions which may arise in a patient with a columnar lined esophagus. Inflammation, ulceration, stricture and fistula formation are discussed, with emphasis on their clinical presentations and diagnoses by endoscopy and radiology. Of the 3 patients, 2 developed adenocarcinoma as a complication of the lesion. The possible malignant potentiality of this anomaly is stressed, and diligent search for a neoplastic focus in all such cases is urged.

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References

  1. Stout AP, Lattes R: Tumors of the esophagus, Atlas of Tumor Pathology. Armed Forces Institute of Pathology, 1957, p 72

  2. Rector LE, Connerly ML: Aberrant mucosa in the esophagus in infants and children. Arch Path 31:285–294, 1941

    Google Scholar 

  3. De la Pava S, Pickren JW, Adler RH: Ectopic gastric mucosa of the esophagus. A study on histogenesis. NY State J Med 64:1831–1835, 1964

    Google Scholar 

  4. Johns BAE: Developmental changes in the oesophageal epithelium in man. J Anat 86:431–442, 1952

    PubMed  Google Scholar 

  5. Bloom W, Fawcett DW: A Textbook of Histology. Ninth edition. Philadelphia, W. B. Saunders, 1968, p 544

    Google Scholar 

  6. Heitmann P, Strauszer T, Sapunar J, et al: Lower esophagus lined with columnar epithelium: morphological and physiological correlation. Gastroenterology 53:611–624, 1967

    PubMed  Google Scholar 

  7. Abrams L, Heath D: Lower oesophagus lined with intestinal and gastric epithelia. Thorax 20:66–72, 1965

    PubMed  Google Scholar 

  8. Allison PR, Johnstone AS: The oesophagus lined with gastric mucous membrane. Thorax 8:87–101, 1953

    PubMed  Google Scholar 

  9. Barrett NR: The lower esophagus lined by columnar epithelium. Surgery 41:881–894, 1957

    PubMed  Google Scholar 

  10. Hershfield NB, Lind JF, Hildes JA, et al: Secretory function of barrett's epithelium. Gut 6:535–539, 1965

    PubMed  Google Scholar 

  11. Adler RH: The esophagus with columnar epithelium: its clinical significance. Geriatrics 20:109–115, 1965

    PubMed  Google Scholar 

  12. Kerckhof J van de, Gahagan T: Regeneration of the mucosal lining of the esophagus. Henry Ford Hosp Med Bull 11:129–134, 1963

    PubMed  Google Scholar 

  13. Goldman MC, Beckman RC: Barrett Syndrome: case report with discussion about concepts of pathogenesis. Gastroenterology 39:104–110, 1960

    PubMed  Google Scholar 

  14. Mossberg SM: The columnar-lined esophagus (Barrett syndrome): an acquired condition? Gastroenterology 50:671–676, 1966

    PubMed  Google Scholar 

  15. McPeak E, Warren S: Histologic features of carcinoma of the cardioesophageal junction and cardia. Amer J Path 24:971–1001, 1948

    Google Scholar 

  16. Carrie A: Adenocarcinoma of the upper end of the oesophagus arising from ectopic gastric epithelium. Brit J Surg 37:474, 1950

    PubMed  Google Scholar 

  17. Goldman JO, Marshak RH, Friedman AL: Primary adenocarcinoma of the esophagus simulating a benign lesion. JAMA 149:144–145, 1952

    Google Scholar 

  18. Morson BC, Belcher JR: Adenocarcinoma of oesophagus and ectopic gastric mucosa. Brit J Cancer 6:127–130, 1952

    PubMed  Google Scholar 

  19. Smithers DW: Adenocarcinoma of the oesophagus. Thorax 11:257–267, 1956

    PubMed  Google Scholar 

  20. Rojas RAM, Vallecillo LA: Primary adenoidcystic carcinoma of the esophagus: report of one case and review of the literature. Arch Otolaryngology 70:197–201, 1959

    Google Scholar 

  21. Armstrong RA, Blalock JB, Carrera GM: Adenocarcinoma of the middle third of the esophagus arising from ectopic gastric mucosa. J Thoracic Surg 37:398–403, 1959

    Google Scholar 

  22. Dawson JL: Adenocarcinoma of the middle oesophagus arising in an oesophagus lined by gastric (parietal) epithelium. Brit J Surg 51:940–942, 1964

    PubMed  Google Scholar 

  23. Azzopardi JG, Manzies T: Primary oesophageal adenocarcinoma: confirmation of its existence by the finding of mucous gland tumors. Brit J Surg 49:497–506, 1962

    PubMed  Google Scholar 

  24. Raphael HA, Ellis FHJr, Dockerty MB: Primary adenocarcinoma of the esophagus: 18 year review and review of literature. Ann Surg 164:785–796, 1966

    PubMed  Google Scholar 

  25. Turnbull ADM, Goodner JT: Primary adenocarcinoma of the esophagus. Cancer 22:915–918, 1968

    PubMed  Google Scholar 

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Authors and Affiliations

  1. From the Department of Medicine, Section of Gastroenterology and Laboratory Service, Veterans Administration Hospital, Washington, DC

    Willard A. Burns MD, Prospero A. Flores MD, Ataullah Moshyedi MD & Rene A. Albacete MD

Authors
  1. Willard A. Burns MD
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  2. Prospero A. Flores MD
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  3. Ataullah Moshyedi MD
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  4. Rene A. Albacete MD
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Additional information

The authors are grateful to Dr. William O. Dobbins, III, for advice in writing this paper, and to Mrs. P. Hoffman for her assistance in preparing the manuscript.

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Burns, W.A., Flores, P.A., Moshyedi, A. et al. Clinical conditions associated with columnar lined esophagus. Digest Dis Sci 15, 607–615 (1970). https://doi.org/10.1007/BF02236016

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  • DOI: https://doi.org/10.1007/BF02236016

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