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Epsilon-Aminocaproic acid therapy in ulcerative colitis

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Abstract

A double-blind cross-over trial of the effect of Epsilon-Aminocaproic acid (EACA) versus placebo on gastrointestinal blood loss in 13 patients with proctocolitis showed no statistically significant reduction in blood loss recorded by the disappearance rate, as detected by whole-body monitoring of parenterally administered59Fe. Moreover, there was poor correlation between sigmoidoscopic findings, using a standard grading, and estimated colonic blood loss. Patients with severe proctocolitis were excluded from the trial. This is the first reported controlled trial of the effect of EACA on blood loss in proctocolitis.

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Authors and Affiliations

  1. Aberdeen Hospitals and Departments of Medicine and Medical Physics, Glasgow, Scotland

    N. A. G. Mowat MB, ChB, MRCP, A. S. Douglas MD, FRCP, FRC(Path), P. W. Brunt MD, MRCP, J. A. R. McIntosh BSc, Priscilla C. King BSc, MSc, PhD & K. Boddy BSc, MSc, PhD, FlnstP

  2. Department of Nuclear Medicine, Scottish Universities Research and Reactor Center, East Kilbride, Glasgow, Scotland

    N. A. G. Mowat MB, ChB, MRCP, A. S. Douglas MD, FRCP, FRC(Path), P. W. Brunt MD, MRCP, J. A. R. McIntosh BSc, Priscilla C. King BSc, MSc, PhD & K. Boddy BSc, MSc, PhD, FlnstP

Authors
  1. N. A. G. Mowat MB, ChB, MRCP
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  2. A. S. Douglas MD, FRCP, FRC(Path)
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  3. P. W. Brunt MD, MRCP
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  4. J. A. R. McIntosh BSc
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  5. Priscilla C. King BSc, MSc, PhD
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  6. K. Boddy BSc, MSc, PhD, FlnstP
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Mowat, N.A.G., Douglas, A.S., Brunt, P.W. et al. Epsilon-Aminocaproic acid therapy in ulcerative colitis. Digest Dis Sci 18, 959–965 (1973). https://doi.org/10.1007/BF01072440

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  • DOI: https://doi.org/10.1007/BF01072440

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