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Gastrin release from gastrinoma cells stimulated with secretin

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Summary

The secretin injection test has been proved to be useful in the diagnosis of gastrinomain vivo. Fresh gastrinoma cells were cultured for a short timein vitro and then stimulated with secretin. A rise in the gastrin concentration in the culture medium was observed within 10 min after the addition of secretin. This fact may be evidence that gastrinoma cells have receptors which bind with secretin resulting in the release of gastrin.

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Authors and Affiliations

  1. Department of Surgery, Department of Radiology and Nuclear Medicine, Kyoto University Medical School, Kawaramachi 54, Sakyoku Shogoin, Kyoto 606, Japan

    Masayuki Imamura Md, Hideki Adachi Md, Kiyoyuki Takahashi Md, Masato Noguchi MD, Naomi Mizutani MD, Masahisa Nakagawa MD & Takayoshi Tobe MD

  2. Division of Pathology, College of Medical Technology, Kyoto University, Kawaramachi 54, Sakyoku Shogoin, Kyoto 606, Japan

    Masayuki Imamura Md, Hideki Adachi Md, Kiyoyuki Takahashi Md, Masato Noguchi MD, Naomi Mizutani MD, Masahisa Nakagawa MD & Takayoshi Tobe MD

  3. Department of Surgery, Shimane Medical School, Shimane, Japan

    Masayuki Imamura Md, Hideki Adachi Md, Kiyoyuki Takahashi Md, Masato Noguchi MD, Naomi Mizutani MD, Masahisa Nakagawa MD & Takayoshi Tobe MD

Authors
  1. Masayuki Imamura Md
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  2. Hideki Adachi Md
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  3. Kiyoyuki Takahashi Md
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  4. Masato Noguchi MD
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  5. Naomi Mizutani MD
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  6. Masahisa Nakagawa MD
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  7. Takayoshi Tobe MD
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Imamura, M., Adachi, H., Takahashi, K. et al. Gastrin release from gastrinoma cells stimulated with secretin. Digest Dis Sci 27, 1130–1136 (1982). https://doi.org/10.1007/BF01391453

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  • DOI: https://doi.org/10.1007/BF01391453

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