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Gastric Myoelectrical Activity in Healthy Children and Children with Functional Dyspepsia

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Abstract

The aim of this study was to investigateabnormalities in pediatric patients with functionaldyspepsia. Fifteen symptomatic pediatric patientsdiagnosed with functional dyspepsia and 17 aged-matchedhealthy controls were studied. Gastric myoelectricalactivity was recorded using surface electrogastrographyfor 1 hr in the fasting state and 1 hr after a testmeal. It was found that, in comparison with thecontrols, the children with functional dyspepsia had alower percentage of 2- to 4-cpm slow waves in bothfasting state (66.0 ± 4.7% vs 79.7 ± 3.1%,P < 0.07) and fed state (72.4 ± 5.4% vs 85.0± 2.9%, P < 0.04), and a significantly higherinstability of the dominant frequency in both fastingstate (0.50 ± 0.05 vs 0.31 ± 0.04, P <0.01) and fed state (0.39 ± 0.05 vs 0.25 ±0.03, P < 0.05). It was also found the postprandial increase inEGG dominant power in the patients was inverselycorrelated with the total symptom score (r = 0.63, P =0.03). It was concluded that abnormal gastricmyoelectrical activity may play a role in the pathogenesis ofpediatric functional dyspepsia.

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Authors
  1. J. D. Z. Chen
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  2. Xuemei Lin
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  3. Ming Zhang
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  4. Ramon B. Torres-Pinedo
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  5. William C. Orr
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Chen, J.D.Z., Lin, X., Zhang, M. et al. Gastric Myoelectrical Activity in Healthy Children and Children with Functional Dyspepsia. Dig Dis Sci 43, 2384–2391 (1998). https://doi.org/10.1023/A:1026661627304

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