Skip to main content
SpringerLink
Log in

Endoscopic Sclerotherapy in Porcine Esophagus Changes Luminal Cross-Sectional Area and Wall Distensibility Dose- and Time-Dependently

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

The dose- and time-dependent effects ofendoscopic sclerotherapy on luminal cross-sectional areaand wall distensibility were studied in pigs at 5 and 12cm proximal to the gastroesophageal junction by means of impedance planimetry. Sixteen healthyanimals underwent two sessions of endoscopicsclerotherapy two weeks apart with injections of either5 or 10 ml of 1% Polidocanol in the distal 7 cm of the esophagus each time. The animals wereinvestigated before sclerotherapy, two weeks after eachsession, and finally six weeks after the last session.Six healthy animals were studied as controls. Endoscopic sclerotherapy caused luminal narrowing in thesclerosed zone followed by normalization six weeks afterthe last treatment (P < 0.05 in both groups). Walldistensibility decreased in the sclerosed zone after treatment with 10 ml sclerosant (P <0.05) followed by partial normalization, while no effectwas found after 5 ml sclerosant (P > 0.2).Progressive dilations were observed in the proximalesophagus in both groups and were most pronounced in the10 ml group (P < 0.05). Wall distensibility did notchange proximal to the site of sclerotherapy in eithergroup (P > 0.1).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. Crafoord C, Frenchner P: New surgical treatment of varicous veins of the esophagus. Acta Otolaryngol 27:422–429, 1939

    Google Scholar 

  2. Kleber G, Sauerbruch T: Pathophysiology and management of esophageal varices. Curr Opin Gastroenterol 8:583–590, 1992

    Google Scholar 

  3. Helpap B, Bollweg L: Morphological changes in the terminal oesophagus with varices, following sclerosis of the wall. Endoscopy 13:229–233, 1981

    Google Scholar 

  4. Jensen LS, Dybdahl H, Juhl C, Nielsen TH: Endoscopic sclerotherapy of esophageal varices in an experimental animal model. A histomorphologic study. Scand J Gastroenterol 21:725–732, 1986

    PubMed  Google Scholar 

  5. Sorensen T, Burcharth F, Pedersen ML, Findahl F: Oesophageal stricture and dysphagia after endoscopic sclerotherapy for bleeding varices. Gut 25:473–477, 1984

    Google Scholar 

  6. Gregersen H, Giversen IM, Rasmussen LM, Toettrup A: Bio-ehanical wall properties and collagen content in the partially obstructed opossum esophagus. Gastroenterology 103:1547–1551, 1992

    PubMed  Google Scholar 

  7. Tung HN, Schulze Delrieu K, Shirazi S, Noel S, Xia Q, Cue K: Hypertrophic smooth muscle in the partially obstructed opossum esophagus. The model: Histological and ultrastructural observations. Gastroente rology 100:853–864, 1991

    Google Scholar 

  8. Juhl CO, Vinter-Jensen L, Djurhuus JC, Gregersen H, Dajani EZ: Biomechanical properties of the oesophagus damaged by endoscopic sclerotherapy. An impedance planimetric study in minipigs. Scand J Gastroenterol 29:867–873, 1994

    PubMed  Google Scholar 

  9. Vinter-Jensen L, Juhl CO, Eika B, Gregersen H, Dajani EZ: Epidermal growth factor attenuates the sclerotherapy induced biomechanical properties of the esophagus: An experimental study in minipigs. Scand J Gastroenterol 30:614–619, 1995

    PubMed  Google Scholar 

  10. Gregersen H, Jensen LS, Djurhuus JC: Change s in oesophageal wall biomechanics after portalve in banding and variceal sclerotherapy measure d by a new technique. An experimental study in rabbits. Gut 29:1699–1704, 1988

    PubMed  Google Scholar 

  11. Guynn TP, Eckhause r FE, Knol JA, Raper SE, Mulholland MW, Nostrant TT, e t al: Injection sclerotherapy-induced esophage al strictures. Risk factors and prognosis. Am Surg 57:567–571, 1991

    PubMed  Google Scholar 

  12. Haynes WC, Sanowski RA, Foutch PG, Bellapravalu S: Esophage al strictures following endoscopic variceal sclerotherapy: Clinical course and response to dilation therapy. Gastrointest Endosc 32:202–205, 1986

    PubMed  Google Scholar 

  13. Schellong H, von Maercke P, Buess G, Pichlmaier H: Oesophage al stenosis— a complication of sclerotherapy of oesophageal varices. Endoscopy 18:223–226, 1986

    Google Scholar 

  14. Kochhar R, Goenka MK, Mehta SK: Esophageal strictures following endoscopic variceal sclerotherapy. Antecedents, clinical profile, and management. Dig Dis Sci 37:347–352, 1992

    PubMed  Google Scholar 

  15. Harris J, The rkelsen EE, Zinner NR: Electrical measurement of ureteral flow. Urodynamics 1971:465–472, 1971

    Google Scholar 

  16. Gregersen H, Djurhuus JC: Impedance planimetry: A new approach to biomechanical intestinal wall properties. Dig Dis 9:332–340, 1991

    PubMed  Google Scholar 

  17. Gregersen H, Jørgensen CS, Dall FH: Biomechanical wall properties in the isolated perfused porcine duodenum: An experimental study using impedance planimetry. J Gastrointest Motil 4:125–135, 1992

    Google Scholar 

  18. Mortensen S, Djurhuus JC, Rask Andersen H: A system for me asurements of micturition urethral cross-sectional are as and pressures. Med Biol Eng Comput 21:482–488, 1983

    PubMed  Google Scholar 

  19. Fung YC: Biomechanics. Mechanical Properties of Living Tissues. New York, Springer-Verlag, 1981

    Google Scholar 

  20. Agha FP: The esophagus after endoscopic injection sclerotherapy: Acute and chronic changes. Radiology 153:37–42, 1984

    PubMed  Google Scholar 

  21. Larson GM, Vandertoll DJ, Netscher DT, Polk HC Jr: Esoph ageal motility: Effects of injection sclerotherapy. Surgery 96:703–710, 1984

    Google Scholar 

  22. Grande L, Planas R, Lacima G, Boix J, Ros E, Esteve M, et al: Sequential esophageal motility studies after endoscopic injection sclerotherapy: A prospective investigation. Am J Gastroente rol 86:36–40, 1991

    Google Scholar 

  23. Sauerbruch T, Wirsching R, Leisner B, Weinzierl M, Pfahler M, Paumgartner G: Esophageal function after sclerotherapy of bleeding varices. Scand J Gastroenterol 17:745–751, 1982

    PubMed  Google Scholar 

  24. Cohen LB, Simon C, Korsten MA, Scherl EJ, Skorniky J, Guelrud MB, et al: Esophageal motility and symptoms after endoscopic injection sclerotherapy. Dig Dis Sci 30:29–32, 1985

    PubMed  Google Scholar 

  25. Mittal RK, Ren J, McCallum RW, Shaffer HA Jr, Sluss J: Modulation of feline esophageal contractions by bolus volume and outflow obstruction. Am J Physiol 258:G208–G215, 1990

    PubMed  Google Scholar 

  26. Schuman BM, Beckman JW, Tedesco FJ, Griffin JW Jr, Assad RT: Complications of endoscopic injection sclerotherapy: A review. Am J Gastroenterol 82:823–830, 1987

    PubMed  Google Scholar 

  27. Iso Y, Kitano S, Higashi H, Koyanagi N, Sugimachi K: A prospective randomized trial comparing two injection methods for endoscopic injection sclerotherapy— large volume and small volume injections of 5% ethanolamine oleate. Gastroenterology 92:1449, 1987 (abstract)

    Google Scholar 

  28. Singal A, Sarin SK, Sood GK, Broor SL: Ulcers after intra-variceal sclerotherapy: Correlation of symptoms and factors affecting healing. J Clin Gastroenterol 12:(3)250–254, 1990

    PubMed  Google Scholar 

Download references

Authors
  1. Jens Aage
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kolsen Petersen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Christian Djurhuus
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jonathan Koff
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lars Vinter-Jensen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hans Gregersen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aage, J., Petersen, K., Djurhuus, C. et al. Endoscopic Sclerotherapy in Porcine Esophagus Changes Luminal Cross-Sectional Area and Wall Distensibility Dose- and Time-Dependently. Dig Dis Sci 43, 521–528 (1998). https://doi.org/10.1023/A:1018802922374

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1018802922374

Search

Navigation