Abstract
The aim of this study was to investigate gastricmyoelectrical activity in patients with functionaldyspepsia. Thirteen healthy subjects and 14 patientswith functional dyspepsia participated in the study. The electrogastrogram (EGG) recording was madein each subject for 30 min in the fasting state and 120min after a standard test meal of 475 calories. Spectralanalysis methods were applied to derive quantitative EGG parameters. There was no difference in theEGG between the patients and controls in the fastingstate. However, abnormalities in the postprandial EGGwere found in the patients. The percentage of 2-4 cpmwaves was significantly lower (74.4 ± 4.0% vs85.7 ± 1.6%, P < 0.03) and the postprandialincrease in EGG dominant power was significantly less(–0.52 ± 0.92 dB vs 2.24 ± 0.88 dB,P < 0.03) in patients than in controls. It was alsofound that the percentage of postprandial 2-4 cpm wavescould be used to differentiate the patients withfunctional dyspepsia from the healthy controls with a specificity of 100% and a sensitivity of 43%. It was concluded that a subset of patients withfunctional dyspepsia have impaired gastric myoelectricalactivity in the fed state.
Similar content being viewed by others
REFERENCES
Holtmann G, Talley NJ: Functional dyspepsia: current treatment recommendations. Drugs 45:918 - 930, 1993
Barbara L, Camilleri M, Corinaldesi R, Crean GP, Heading RC, Johnson AG, Malagelada JR, Stanghe llim V, Wienbeck M: Definition and investigation of dyspepsia. Consensus of an international ad hoc work party. Dig Dis Sci 34:1272- 1276, 1989
Hausken T, Be rstad A: Effect of glyce ryl trinitrate on antral motility and symptoms in patients with functional dyspepsia. Scand J Gastroenterol 29:23- 28, 1994
Degryse H, De Schepper A, Verlinden M: A double-blind ¯ uoroscopic study of cisapride on gastrointestinal motility in patients with functional dyspepsia. Scand J Gastroenterol Suppl 195:1- 4, 1993
Riezzo G, Cucciara S, Chiloiro M, Minella R, Guerra V, Giorgio I: Gastric emptying and myoe lectrical activity in children with nonulcer dyspepsia: e ffect of cisapride. Dig Dis Sci 40:1428 - 1434, 1995
Gilja OH, Hausken T, Wilhelmsen I, Be rstad A: Impaired accommodation of proximal stomach to a me al in functional dyspepsia. Dig Dis Sci 41:689 - 696, 1996
Barbe ra R, Feinle C, Read NW: Nutrient-spe cific modulation of gastric me chanosensitivity in patients with functional dyspepsia. Dig Dis Sci 40:1636 - 1641, 1995
You CH, Chey WY, Lee KY: Gastric and small intestinal myoe lectrical dysrhythmia associated with chronic intractable nausea and vomiting. Ann Intern Med 95:449 - 451, 1981
Abe ll TL, Camilleri M, Hench VS, Malage lada J-R: Gastric ele ctromechanical function and gastric emptying in diabetic gastropare sis. Eur J Gastroenterol Hepatol 3:163- 167, 1991
Koch KL, Stern RM, Stewart WR, Vasey MW: Gastric emptying and gastric myoe lectrical activity in patients with diabetic gastropare sis: Effect of long-term dompe ridone treatme nt. Am J Gastroente rol 84:1069 - 1075, 1989
Chen J, McCallum RW: Gastric slow wave abnormalities in patients with gastroparesis. Am J Gastroenterol 87:477- 482, 1992
Geldof H, Van Der Schee EJ, Blankenste in MV, Grashuis JL: Electrogastrographic study of gastric myoele ctrical activity in patients with unexplained nausea and vomiting. Gut 27:799 - 808, 1986
Chey WY (ed): Functional Disorders of the Digestive Tract. New York, Raven Press, 1983
Hasle r WL, Soudah HC, Dulai G, Owyang C: Mediation of hype rglycemia-evoked gastric slow-wave dysrhythmias by endogenous prostaglandins. Gastroente rology 108:727- 736, 1995
Kim CH, Zinsmeister AR, Malage lada JR: Effect of gastric dysrhythmia on postcibal motor activity of the stomach. Dig Dis Sci 33:193- 199, 1988
Chen J, Pan J, McCallum RW: Clinical significance of gastric myoe lectrical dysrhythmias. Dig Dis Sci 13:275- 290, 1995
Cucciara S, Minella R, Riezzo G, Vallone G, Caste llone F, Auricchio S: Reversal of gastric e lectrical dysrhythmias by cisapride in children with functional dyspepsia: Report of three cases. Dig Dis Sci 37:1136 - 1140, 1992
Jebbink HJA, Van Be rge-He negouwen, Bruijs PPM, Akkermans LMA, Smout AJPM: Gastric myoele ctrical activity and gastrointestinal motility in patients with functional dyspepsia. Eur J Clin Inve st 25:429 - 437, 1995
Chen J, McCallum RW (ed): Electrogastrography: Principles and Applications. New York, Raven Press, 1994
Smout AJPM, van der Sche e EJ, Grashuis JL: What is measured in ele ctrogastrography? Dig Dis Sci 25:179 - 187, 1980
Familoni BO, Bowes KL, Kingma YJ, Cote KR: Can transcutaneous recordings dete ct gastric electrical abnormalities? Gut 32:141- 146, 1991
Chen J, Schirme r BD, McCallum RW: Serosal and cutaneous recordings of gastric myoele ctrical activity in patients with gastropare sis. Am J Physiol 266:G90 - G98, 1994
Geldof H, van der Sche e EJ, Grashuis JL: Electrogastrographic characteristics of interdigestive migrating complex in humans. Am J Physiol 250:G165- G171, 1986
You CH, Lee KY, Chey WY, Menguy R: Electrogastrographic study of patients with unexplained nause a, bloating and vomiting. Gastroente rology 79:311- 314, 1980
Stern RM, Kenneth LK, Leibowitz HW, Lindblad IM, Shupert CL, Stewart WR: Tachygastria and motion sickness. Aviat Space Environ Med 56:1074 - 1077, 1985
Sun WM, Smout A, Malbert C, Ede lbroek MAL, Jones K, Dent J, Horowitz M: Relationship between surface ele ctrogastrography and antropyloric pressure. Am J Physiol 31:G424 - G430, 1994
Walsh JW, Halse r WL, Nugent CE, Owyang C: Proge ste rone and e strogen are potential mediators of gastric slow-wave dysrhythmia in nausea of pregnancy. Am J Physiol 270:G506 - G514, 1996
Abe ll TL, Malage lada J-R, Lucas AR, Brown ML, Camilleri M, Go VL, Azpiroz F, Callaway CW, Kao PC, Zinseme ister AR: Gastro-me chanical and neurohormonal function in anorexia nervosa. Gastroente rology 93:958 - 965, 1987
Cucchiara S, Riezzo G, Minella R, Vallone G, Vallone PF, Giorgio L, Auricchio S: Electrogastrography in nonulcer dyspepsia. Arch Dis Child 67:613- 617, 1992
Koch KL: Gastric dysrhythmia and the current status of electrogastrography. Pract Gastroenterol 13:37- 44, 1989
Desvaranne s SB, Mizafi M, Dubois A: Relation between postprandial gastric emptying and cutaneous ele ctrogastrogram in primates. Am J Physiol 261:G248 - G255, 1991
Jebbink HJ, Bruijs PP, Bravenboe r B, Akkermans LM, van-Berghe-Hennegouwen GP, Smout AJ: Gastric myoe lectrical activity in patients with type I diabete s mellitus and autonomic neuropathy. Dig Dis Sci 39:2376 - 2383, 1994
Chen J: A computerized data analysis system for ele ctrogastrogram. Comp Biol Med 22:45- 58, 1992
Geldof H, vander Schee EJ, Smout AJPM: Myoele ctrical activity of the stomach in gastric ulcer patients: An ele ctrogastrographic study. J Gastrointest Motil 1:122- 130, 1989
Chen J, McCallum RW: The response of e lectrical activity in normal human stomach to water and solid meals. Med Biol Eng Comput 29:351- 357, 1991
Chen J, Co E, Liang J, Pan J, Sutphen J, Torre s-Pinedo RB, Orr WC: Patterns of gastric myoe lectrical activity in human subjects with different ages. Am J Physiol 272:G1022- G1027, 1997
Chen J, Lin ZY, McCallum RW: Abnormal gastric myoele ctrical activity and delaye d gastric emptying in patients with symptoms sugge stive of gastroparesis. Dig Dis Sci 41:1538 - 1545, 1996
Rothstein RD, Alavi A, Reynolds JC: Electrogastrography in patients with gastroparesis and effect of long-term cisapride. Dig Dis Sci 38:1518 - 1524, 1993
Levanon D, Zhang M, Orr WC, Chen JDZ: Effects of meal volume and composition on gastric myoe lectrical activity. Am J Physiol 274:G430 - G434, 1998
Rights and permissions
About this article
Cite this article
Lin, X., Levanon, D. & Chen, J.D.Z. Impaired Postprandial Gastric Slow Waves in Patients with Functional Dyspepsia. Dig Dis Sci 43, 1678–1684 (1998). https://doi.org/10.1023/A:1018806913907
Issue Date:
DOI: https://doi.org/10.1023/A:1018806913907