Abstract
Objectives: To investigate the effects of different levels ofhormones on the ciliary activity of human oviducts and,consequently, to assess their possible role in tubalimplantation of the fertilized egg.
Design: Fallopian tube epithelial samples were incubatedin media with the addition of Estradiol (E2), progesterone(P), human menopausal gonadotropin (hMG), LH, or pureFSH (Metrodin) in different concentrations. The ciliary beatfrequency (CBF) was measured after 24 h of incubation.Then the media were exchanged to media without theaddition of hormones and the CBF was measured again 24 hlater by using the photoelectric technique.
Setting: University teaching hospital, IVF unit.
Results: Twenty-four hr after the addition of P to the culturemedium in concentrations of 0.5 or 1 ng/ml a significantdecline of the CBF down to 63% of the control level wasobserved (P < 0.001) and with P in concentration of 2 ng/ml or greater, 50–70% of the cilia were paralyzed. Theseeffects of P were found to be reversible. Incubation with E2induced a slight increase of 4% in the mean CBF (P =0.002). Twenty-four hr incubation with Metrodin, Pergonal,or LH did not affect ciliary motility.
Conclusions: Higher levels of progesterone cause ciliarydysfunction and subsequently may be a possible cause ofectopic pregnancy.
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REFERENCES
Ectopic pregnancy. ACOG Tech Bull 1990;150:1–7
Lavy G, DeCherney AH: The hormonal basis of ectopic pregnancy. Clin Obstet Gynecol 1987;30:217–224
Wu CH, Mastroianni L, Mikhail G: Steroid hormones in monokey oviductal fluid. Fertil Steril 1977;28:1250–1256
Knoll M, Talbot P: Cigarette smoke inhibits oocyte cumulus complex pick-up by the oviduct in vitro independent of ciliary beat frequency. Reprod Toxicol 1998;12:57–68
Pauerstein CJ: Clinical implication of oviductal physiology and biochemistry. Gynecol Invest 1975;6:253–264
Pulkkinen MO, Jaakkola UM: Low serum progesterone levels and tubal dysfunction-A possible cause of ectopic pregnancy. Am J Obstet Gynecol 1989;161:934–937
Jansen RPS: Endocrine response in the Fallopian tube. Endocrine Reviews 1984;5:525–551
Paltieli Y, Weichselbaum A, Hoffman N, Eibschitz I, Kam Z: Laser scattering instrument for real time in-vivo measurement of ciliary activity in human Fallopian tube. Hum Reprod 1995;10:1638–1641
Beral V: An epidemiological study on the recent trends in ectopic pregnancy. Br J Obstet Gynecol 1975;82:775–782
Liuko P, Erkkola R, Laakso L: Ectopic pregnancies during the use of low-dose progestogens for oral contraception. Contraception 1977;16:575–580
Tatum HJ, Schmidt FH: Contraceptive and sterilization practices and extrauterine pregnancy: a realistic perspective. Fertile Steril 1977;28:407–421
Gemzel C, Guillome J, Wang CF: Ectopic pregnancy following treatment with human gonadotropin. Am J Obstet Gynecol 1982;143:761–765
Assisted reproductive technology in the United States and Canada: 1992 results generated from the American fertility society/Society for assisted reproductive technology register. Fertil Steril 1994;62:1121–1128
McBain JC, Pepperell RJ, Robinson HP, Brown JB: An unexpectedly high rate of ectopic pregnancy following the induction of ovulation with human pituitary and chorionic gonadotropin. Br J Obstet Gynecol 1980;87:5–9
Halbert SA, Tam PY, Adams RJ, Blandau RJ: An analysis of the mechanism of egg transport in the ampulla of the rabbit oviduct. Gynecol Invest 1976;7:306–320
Brenner RM, Slayden OD: Oestrogen action in the endometrium and oviduct of rhesus monkeys during RU486 treatment. Hum Reprod 1994;9(suppl):82–97
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Paltieli, Y., Eibschitz, I., Ziskind, G. et al. High Progesterone Levels and Ciliary Dysfunction—A Possible Cause of Ectopic Pregnancy. J Assist Reprod Genet 17, 103–106 (2000). https://doi.org/10.1023/A:1009465900824
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DOI: https://doi.org/10.1023/A:1009465900824