Abstract
The case of an infant female aged 1 month with severe infections, failure to thrive, and skin erythroderma is reported. Immunological studies demonstrated a severe combined immunodeficiency (SCID) with B cells and normal serum IgM levels. Studies of T-cell subpopulations showed a defect of a subset of T helper cells. Possible pathogenetic mechanisms are discussed.
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Businco, L., Pandolfi, F., Rossi, P. et al. Selective defect of a T helper subpopulation in severe combined immunodeficiency. J Clin Immunol 1, 125–130 (1981). https://doi.org/10.1007/BF00915390
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DOI: https://doi.org/10.1007/BF00915390