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Mannose 6-Phosphate/Insulin-Like Growth Factor 2 Receptor, a Bona Fide Tumor Suppressor Gene or Just a Promising Candidate?

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Abstract

The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R)3 is considereda “candidate” tumor suppressor gene. This hypothesis has been provoked by the identificationof loss of heterozygosity (LOH) at the M6P/IGF2R locus on chromosome 6q26 in breast andliver cancer, accompanied by point mutations in the remaining allele. Somatic mutations incoding region microsatellites have also been described in replication error positive (RER+)tumors of the gastrointestinal tract, endometrium and brain. These genetic data are compelling,but a tumor suppressor gene candidate has to meet functional as well as genetic criteria. Thisreview weighs the evidence and discusses the observations that are necessary to promoteM6P/IGF2R from candidate to bona fide tumor suppressor gene.

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  1. Lombardi Cancer Center, Georgetown University, N.W. Washington, D.C., 20007

    Stacey A. DaCosta, Lisa M. Schumaker & Matthew J. Ellis

  2. Lombardi Cancer Center, Georgetown University, Room E518, Research Building, 3970 Reservoir Road, N.W. Washington, D.C., 20007

    Matthew J. Ellis

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DaCosta, S.A., Schumaker, L.M. & Ellis, M.J. Mannose 6-Phosphate/Insulin-Like Growth Factor 2 Receptor, a Bona Fide Tumor Suppressor Gene or Just a Promising Candidate?. J Mammary Gland Biol Neoplasia 5, 85–94 (2000). https://doi.org/10.1023/A:1009571417429

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