Abstract
The role of the liver in the plasma clearance of l-dopa in the rat was examined. Some published studies which ascribe an important role to the liver in l-dopa clearance are discussed and critically evaluated. Contrary evidence suggesting that the liver is not a significant site of l-dopa clearance in vivo ispresented. The plasma concentration of l-dopa during intravenous infusion of the drug was not significantly reduced after a single passage through the liver. All of the data discussed are consistent with the conclusion that the liver plays a minor role in l-dopa clearance in vivo.It is suggested that the small intestine is the major site of metabolism of orally administered l-dopa.
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Mearrick, P.T., Graham, G.G. & Wade, D.N. The role of the liver in the clearance ofl-dopa from plasma. Journal of Pharmacokinetics and Biopharmaceutics 3, 13–23 (1975). https://doi.org/10.1007/BF01066592
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DOI: https://doi.org/10.1007/BF01066592