Abstract
The pharmacokinetics of N-acetylprocainamide (NAPA) have been studied in three normal subjects who received 500 mg of this compound by timed intravenous injection. Plasma N APA concentrations and urine excretion were measured by quadrupole mass fragmentography, and a three- compartment pharmacokinetic model was used for data analysis. NAPA elimination half-life and total distribution volume averaged 6.0 hr and 1.38 liters/kg, respectively. Renal excretion of unchanged NAPA accounted for 81% of its elimination, and the mean renal NAPA clearance was 179 ml/min. Approximately 2% of the injected NAPA was deacetylated to procainamide. The fate was not determined of 17% of the NAPA that was estimated to have been eliminated during the 16- hr study period.
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Strong, J.M., Dutcher, J.S., Lee, WK. et al. Pharmacokinetics in man of theN-acetylated metabolite of proeainamide. Journal of Pharmacokinetics and Biopharmaceutics 3, 223–235 (1975). https://doi.org/10.1007/BF01066919
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DOI: https://doi.org/10.1007/BF01066919