Abstract
A case of multiple intracranial germ cell tumor in which a pineal tumor regressed spontaneously after resection of the cerebellar mass is reported. Immunohistochemical staining of the cerebellar mass showed that most of the infiltrating lymphocytes were positive for CD3 and CD8. The anti-Ki-67 monoclonal antibody MIB-1 staining of the resected tumor revealed a high MIB-1 positivity ratio (36.1%) among the large tumor cells, and TUNEL staining demonstrated that positivity in up to 6% of the tumor cells. Possible mechanisms responsible for this spontaneous regression including immunological responses and apoptosis induced by T lymphocytes are discussed.
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Honore LH, Moloney PJ: Malignant germ cell tumor of the testis: spontaneous regression of pulmonary metastases with 7-year survival. J Urol 116: 382–4, 1976
Fujimaki T, Matsutani M, Funada N, Kirino T, Takakura K, Nakamura O, Tamura A, Sano K: CT and MRI features of intracranial germ cell tumors. J Neuro-Oncol 19: 217–26, 1994
Matsutani M, Sano K, Takakura K, Fujimaki T, Nakamura O, Funata N, Seto T: Primary intracranial germ cell tumors: A clinical analysis of 153 histologically verified cases. J Neurosurg 86: 446–455, 1997
Fujimaki T, Matsuno A, Sasaki T, Toyoda T, Matsuura R, Ogai M, Kitanaka C, Asai A, Matsutani M, Kirino T: Proliferative activity of central neurocytoma: Measurement of tumor volume doubling time, MIB-l staining index and bromodeoxyuridine labeling index. J Neuro-Oncol 32: 103–109, 1997
Gavrieli Y, Sherman Y, Ben SS: Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493–501, 1992
Russel D, Rubinstein R. Tumours of totipotential germ cells. In: Russel D, Rubinstein R, (ed). Pathology of tumours of the nervous system. 5th ed. Baltimore: Williams & Wilkins, 1989, pp 665–687
Takei Y, Pearl GS: Ultrastructural study of intracranial yolk sac tumor: with special reference to the oncologic phylogeny of germ cell tumors. Cancer 48: 2038–46, 1981
Richie J. Germ cell neoplasm. In: Walsh P, Retik A, Stamey T, Vaughan Jr. E, (ed). Campbell's urology. 6th ed. Philadelphia: W.B. Saunders, 1992, p1225.
Casentini L, Colombo F, Pozza F, Benedetti A: Combined radiosurgery and external radiotherapy of intracranial germinomas. Surg Neurol 34: 79–86, 1990
Aydin F, Ghatak NR, Radie KK, Kinard J, Land SD: The short-term effect of low-dose radiation on intracranial germinoma. A pathologic study. Cancer 69: 2322–6, 1992
Mascalchi M, Roncaroli F, Salvi F, Frank G: Transient regression of an intracranial germ cell tumour after intravenous steroid administration: a case report. J Neurol Neurosurg Psych 64: 670–672, 1998
Sano K, Matsutani M, Seto T: So-called intracranial germ cell tumours: personal experiences and a theory of their pathogenesis. (Review). Neurol Research 11: 118–26, 1989
Sawamura Y, Hamou MF, Kuppner MC, de TN: Immunohistochemical and in vitro functional analysis of pinealgerminoma infiltrating lymphocytes: report of a case. Neurosurg 25: 454–7, 1989
Bell MC, Edwards RP, Partridge EE, Kuykendall K, ConnerW, Gore H, Turbat-Herrara E, Crowley-Nowick PA: CD8+ T lymphocytes are recruited to neoplastic cervix. J Clin Immunol 15: 130–6, 1995
Economou JS, Belldegrun AS, Glaspy J, Toloza EM, Figlin R, Hobbs J, Meldon N, Kaboo R, Tso CL, Miller A, Lau R, McBride W, Moen RC: In vivo trafficking of adoptively transferred interleukin-2 expanded tumor-infiltrating lymphocytes and peripheral blood lymphocytes. Results of a double gene marking trial. J Clin Investig 97: 515–21, 1996
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Fujimaki, T., Mishima, K., Asai, A. et al. Spontaneous Regression of a Residual Pineal Tumor after Resection of a Cerebellar Vermian Germinoma. J Neurooncol 41, 65–70 (1999). https://doi.org/10.1023/A:1006155120191
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DOI: https://doi.org/10.1023/A:1006155120191