Skip to main content
SpringerLink
Log in

Copper in brain

  • An Overview
  • Published:
Neurochemical Research Aims and scope Submit manuscript

Conclusion

Ten years ago our knowledge on copper-containing proteins and enzymes of brain was limited to 2–3 poorly studied fractions. At the present time we have clear evidences for at least 10 copper-containing proteins and enzymes in brain, some of them were studied in detail.

It is clear now that copper has an exclusively important role in nervous tissue, but in the next decade other copper proteins and enzymes will undoubtedly be discovered in brain. The main direction in future studies of copper proteins and enzymes should probably be connected with the isolation of copper-containing proteins and enzymes from different subcellular fractions of brain, the determination of the exact significance each of these proteins in brain, the interrelationship between different copper-containing structures, and the establishment of roles of these proteins in various pathologies of nervous system.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hart, E. B., Steenbock, H., Waddell, J., andElvehjem, C. A., 1928. J. Biol. Chem. 77:798–812.

    Google Scholar 

  2. Bennetts, H. W., 1932. Aust. Vet. J. 8:137–142, 183–184.

    Google Scholar 

  3. Everson, G. J., Tsai, H. C., andWang, T., 1967. J. Nutr. 93:533–540.

    Google Scholar 

  4. Underwood, E. J., 1962. Trace Elements in Animal Nutrition, Academic Press, New York.

    Google Scholar 

  5. Carlton, W. W., andKelly, W. A., 1969. J. Nutr. 97:42–52.

    Google Scholar 

  6. De Baecque, C., Raine, R. S., andSpenser, P. S., 1976. Neuropathol. Appl. Neurobiol. 2:459–467.

    Google Scholar 

  7. Patterson, D. S. P., Foulkes, J. A., Sweasey, D., Glancy, E. M., andTerlecki, S., 1974. J. Nutr. 23:1245–1253.

    Google Scholar 

  8. Prohaska, J. R., andWells, W. W., 1974. J. Neurochem. 23:91–98.

    Google Scholar 

  9. Dipaolo, R. W., Kanfer, J. N., andNewberne, P. M., 1974. J. Neuropathol. Exp., Neurol. 33:226–236.

    Google Scholar 

  10. Hunt, D. M., andPort, A. E., 1979. Life Sci. 24:1453–1466.

    Google Scholar 

  11. Keen, C. L., andHurleu, L. S., 1976. Science 193:244–246.

    Google Scholar 

  12. O'Dell, B. L., andFeller, D. J., 1980. J. Neurochem. 34:1259–1263.

    Google Scholar 

  13. Morgan, R. F., andO'Dell, B. L., 1977. J. Neurochem. 28:207–211.

    Google Scholar 

  14. O'Dell, B. L., Smith, R. M., andKings, R. A., 1976. J. Neurochem. 26:451–455.

    Google Scholar 

  15. Smith, R. M., Osborn-White, S. W., andO'Dell, B. L., 1976. J. Neurochem. 26:1145–1148.

    Google Scholar 

  16. Galacher, C. H., andReeve, V. S., 1971. Aust. J. Exp. Biol. Med. Sci. 49:21–31.

    Google Scholar 

  17. Menkes, J. H., Alter, M., Steigleder, G. K., Weakley, D. R., andSung, J. H., 1962. Pediatrics 29:764–779.

    Google Scholar 

  18. Danks, D. M., Campbell, P. E., Stevens, B. J., Mayne, V., andCartwright, E., 1972. Pediatrics 50:188–201.

    Google Scholar 

  19. Danks, D. M. 1977. Inorg. Perspect. Biol. Med. 1:73–100.

    Google Scholar 

  20. French, J. H., Sherfurd, E. S., Lubell, H., Blotz, M., andMoore, C. L., 1972. Arch. Neurol. 26:229–244.

    Google Scholar 

  21. Venturini, G., 1973. J. Neurochem. 21:1147–1151.

    Google Scholar 

  22. O'Dell, B. L., Hardwick, B. C., Reynolds, G., andSavage, J. E., 1961. Proc. Soc. Exp. Biol. Med. 108:402–405.

    Google Scholar 

  23. Harris, E. D., Gonnerman, W. D., Savage, J. E., andO'Dell, B. L., 1974. Biochim. Biophys. Acta 341:332–344.

    Google Scholar 

  24. Kenneth, A. G. D., andKlevay, L. M., 1980. Nutr. Rep. Int. 22:295–300.

    Google Scholar 

  25. Gotto, A. M., Miller, N. E., andOliver, M. F. (eds) 1978. High Density Lipoproteins and Atherosclerosis. Elsevier-North Holland, Amst. New York.

    Google Scholar 

  26. Wilson, S. A. K., 1912. Brain 34:295–509.

    Google Scholar 

  27. Port, A. E., andHunt, D. M., 1979. Biochem. J. 183:721–730, and references therein.

    Google Scholar 

  28. Edwards, C. Q., Williams, D. M., andCartwright, G. E., 1979. Clin. Genet. 15:311–316.

    Google Scholar 

  29. Rajan, K. S., Colburn, R. W., andDavis, J. M., 1976. Life Sci. 18:423–432.

    Google Scholar 

  30. Warren, P. J., Earl, C. J., andThompson, R. H. S., 1960. Brain 83:709–717.

    Google Scholar 

  31. O'Dell, B. L., 1968. Fed. Proc. 27:199–207.

    Google Scholar 

  32. Bremner, I., andMills, C. F., 1981. Phil. Trans., Roy Soc. London, B 294:75–89.

    Google Scholar 

  33. Theil, E. C., andCalvert, K. T., 1978. Biochem. J. 170:137–143.

    Google Scholar 

  34. Curson, G., 1967. Int. Rev. Neurobiol. 10:323–347.

    Google Scholar 

  35. Walshe, J. M., 1967. Brain 90:149–170.

    Google Scholar 

  36. Sternleib, I., andSheinberg, I. H., 1961. Ann. N.-Y., Acad. Sci. 94:71–78.

    Google Scholar 

  37. Matsuba, I., andTakahashi, I., 1970. Analyt. Biochem. 36:182–191.

    Google Scholar 

  38. Smeyers-Verbeke, J., May, C., Drochmans, P., andMassart, D. L., 1977. Analyt. Biochem. 83:746–753.

    Google Scholar 

  39. Banevska, P. S., 1972. Dr. Ph. Thesis, Leningrad.

  40. Tumanova, S. Yu., andNalbandyan, R. M., Neurochimia (Russ.) to be published.

  41. Porter, H., andFolch, J., 1956. Prog. Neurobiol. 1:40–51.

    Google Scholar 

  42. Porter, H., 1966. Biochemistry of copper, (J. Peisach, Ph. Aisen, and W. Blumberg, eds.). Academic Press, New York, pp. 159–174.

    Google Scholar 

  43. Porter, H., andFolch, J., 1957. J. Neurochem. 1:260–265.

    Google Scholar 

  44. Carrico, R. J., andDeutsch, H. F., 1969. J. Biol. Chem. 244:6087–6093.

    Google Scholar 

  45. Fushimi, H., Hamison, C. R., andRavin, H. A., 1971. J. Biochem. 69:1041–1054.

    Google Scholar 

  46. Sharoyan, S. G., Shaljian, A. A., Nalbandyan, R. M., andBuniatian, H. Ch., 1977. Biochim. Biophys. Acta 493:478–487.

    Google Scholar 

  47. Malkin, R., andMalmström, B. G., 1970. Adv. Enzymol. 33:177–244.

    Google Scholar 

  48. Gasparov, V. S., Nalbandyan, R. M., andBuniatian, H. Ch., 1979. FEBS-Letters. 97:37–40.

    Google Scholar 

  49. Walaas, E., Lövstad, R. A., andWalaas, O., 1966. Arch. Biochem. Biophys. 121:480–488.

    Google Scholar 

  50. Grigoryan, N. A., Nalbandyan, R. M., andBuniatian, H. Ch., 1981. Biochem. Biophys. Res. Comms. 100:921–928.

    Google Scholar 

  51. Mikaelyan, M. V., Grigoryan, N. A., andNalbandyan, R. M., 1982 in press.

  52. Mirzoyan, S. A., andNalbandyan, R. M., 1982 in press.

  53. Norton, D. S., andHeaton, F. W., 1977. Biochem. Soc. Trans. 5:425–427.

    Google Scholar 

  54. Evans, G. W., 1973. Physiol. Rev. 53:535–570.

    Google Scholar 

  55. Holmberg, C. G., andLaurell, C. B., 1948. Acta Chem. Scand. 2:550–556.

    Google Scholar 

  56. Osaki, S. J., Johnson, D. A., andFrieden, E., 1966. J. Biol. Chem. 241:2746–2751.

    Google Scholar 

  57. Osaki, S. J., McDermott, J. A., andFrieden, E., 1964. J. Biol. Chem. 239:3570–3575.

    Google Scholar 

  58. Al-Timini, D. J., andDormandy, Th. L., 1977. Biochem. J. 168:283–288.

    Google Scholar 

  59. Steve, H., andFrieden, E., 1975. Biochem. Biophys. Res. Comms. 67:1326–1331.

    Google Scholar 

  60. Moshkov, K. A., Lakatos, S., Hajdu, J., Zavodszky, P., andNeifakh, S. A., 1979. Europ. J. Biochem. 94:127–134.

    Google Scholar 

  61. van der Hamer, C. J. A., Morell, A. G., Scheinberg, J. H., Hickman, J., andAshwell, G., 1970. J. Biol. Chem. 245:4397–4402.

    Google Scholar 

  62. Topam, R. W., andFrieden, E., 1970. J. Biol. Chem. 245:6698–6705.

    Google Scholar 

  63. Ganier, A., Tosi, L., andSteinbuch, M., 1981. Biochem. Biophys. Res. Comms. 98:66–71.

    Google Scholar 

  64. Bradshaw, R. A., andPeters, T., 1969. J. Biol. Chem. 244:5582–5589.

    Google Scholar 

  65. Neumann, P. Z., andSass-Kortsaak, A., 1967. J. Clin. Invest. 46:640–658.

    Google Scholar 

  66. Chutkow, J. J., 1978. Proc. Soc. Exp. Biol. Med. 158:113–116.

    Google Scholar 

  67. Ymanari, T., Ishida, J., Hayakawa, K., andMiyazaki, M., 1978. Chem. Pharm. Bull. 26:2594–2595.

    Google Scholar 

  68. Baker, B. L., andHultquist, D. E., 1978. J. Biol. Chem. 253:8444–8451.

    Google Scholar 

  69. Helle, K. B., Serck-Hanssen, G., Sovik, O., Gutteberg, T. J., Hansen, J. R., Ose, L., andStoa, K. F., 1976. Clin. Exptl. Pharm. Physiol. 3:487–491.

    Google Scholar 

  70. Geffen, L. B., andLivett, B. G., 1971. Physiol. Rev. 51:98–157.

    Google Scholar 

  71. Schanberg, S. M., andKirshner, N., 1976. Biochem. Pharm. 25:617–621.

    Google Scholar 

  72. Buffoni, F., andBlaschko, H., 1964. Proc. Roy. Soc., B 161:153–167.

    Google Scholar 

  73. Kapeller-Adler, R., 1970. Amine Oxidase and Methods for their Study, Wiley-Inter., New York.

    Google Scholar 

  74. Blaschko, H., andWeissman, N., Carnes, W. H., andCoulson, W. F., 1965. Biochem. J. 96:4c-5c.

    Google Scholar 

  75. Mehrabyan, Z. B., Gulkhandanyan, G. V., andNalbandyan, R. M., 1981. Biochimia (Russ.) 46:612–619.

    Google Scholar 

  76. Pinnell, S. R., andMartin, G., 1968. Proc. Natl. Acad. Sci. USA 61:708–713.

    Google Scholar 

  77. Kagan, H. M., 1978. Connect. Tiss. Res. 6:167–169.

    Google Scholar 

  78. O'Dell, B. L., Hardwick, B. C., Reynolds, G., andSavage, J. E., 1961. Proc. Soc. Exptl. Biol. Med. 108:402–405.

    Google Scholar 

  79. Coulson, W. F., andCarnes, W. H., 1963. Am. J. Pathol. 45:945–954.

    Google Scholar 

  80. Harris, E. D., 1976. Proc. Natl. Acad. Sci. USA 73:371–374.

    Google Scholar 

  81. Rayton, K. J., andHarris, E. D., 1979. J. Biol. Chem. 254:621–626.

    Google Scholar 

  82. Kägi, J. H. R., andValee, B. L., 1960. J. Biol. Chem. 235:3460–3465.

    Google Scholar 

  83. Riordan, J. R., andGower, J., 1975. Biochim. Biophys. Acta 411:393–398.

    Google Scholar 

  84. Hildebrand, C. E., andEnger, M. D., 1980. Biochemistry 19:5850–5857.

    Google Scholar 

  85. Hartmann, H. J., andWeser, U., 1977. Biochim. Biophys. Acta 491:211–222.

    Google Scholar 

  86. Minkel, D. T., Poulsen, K., Wielgns, S., Shaw, C. F., andPeterling, D. H., 1980. Biochem. J. 191:475–485.

    Google Scholar 

  87. Porter, H., 1968. Biochim. Biophys. Acta 154:236–242.

    Google Scholar 

  88. Porter, H., 1971. Biochim. Biophys. Acta 229:143–148.

    Google Scholar 

  89. Udom, A. O., andBrady, F. O., 1980. Biochem. J. 187:329–335.

    Google Scholar 

  90. Shaljian, A. A., Sharoyan, S. G., Nalbandyan, R. M., andBuniatian, H. Ch., 1980. Voprosi Biochimii Mozga, (Russ.) 14:5–14.

    Google Scholar 

  91. Irons, R. D., andSmith, J. C., 1977. Chem. Biol. Interactions 18:83–98.

    Google Scholar 

  92. Hart, A., andKeatling, R., 1980. Chem. Biol. Interactions. 29:67–83.

    Google Scholar 

  93. McCord, J. M., andFridovich, I., 1969. J. Biol. Chem. 244:6049–6055.

    Google Scholar 

  94. Fridovich, I., 1974. Adv. Enzymol. 41:35–97.

    Google Scholar 

  95. Carrico, R. J., Deutch, H. F., 1969. J. Biol. Chem. 244:6089–6093.

    Google Scholar 

  96. Lippitt, B., andFridovich, I., 1973. Arch. Biochem. Biophys. 159:738–741.

    Google Scholar 

  97. Fried, R., andMandell, P., 1975. J. Neurochem. 24:433–438.

    Google Scholar 

  98. Thomas, T. N., Priest, D. G., andZemp, J. W., 1976. J. Neurochem. 27:309–310.

    Google Scholar 

  99. Loomis, T., Iee, G., andStahl, W., 1976. Experientia. 32:1374–1376.

    Google Scholar 

  100. Sharoyan, S. G., Shaljian, A. A., Nalbandyan, R. M., andBuniatian, H. Ch., 1976. Voprosi Biochimii Mozga (Russ.) 11:105–115.

    Google Scholar 

  101. Sharoyan, S. G., Shaljian, A. A., Nalbandyan, R. M., andBuniatian, H. Ch., 1976. Dokladi Academii Nauk SSSR (Russ.) 226:975–977.

    Google Scholar 

  102. Gutteridge, M. C., 1977. Biochem. Biophys. Res. Comms. 77:379–386.

    Google Scholar 

  103. Kellog, E. W., andFridovich, I., 1975. J. Biol. Chem. 250:8812–8817.

    Google Scholar 

  104. Marklund, S., andPlum, C. M., 1978. J. Neurochem. 31:521–523.

    Google Scholar 

  105. Grigoryan, N. A., andNalbandyan, R. M., 1980. The significance of Superoxide Dismutase and Superoxide. v. 1. Chemical and Biochemical Aspects (Bannister, J. V., and Hill, H. A. O., eds) Elsevier-North Holland Amst.-N.-Y.

    Google Scholar 

  106. Bannister, W. H., andBannister, J. V., 1980. (eds.) The significance of Superoxide and Superoxide Dismutase. v2. Biological and Clinical Aspects. Elsevier-North Holland Amst.-N.Y.

    Google Scholar 

  107. Skotland, T., andLjones, T., 1979. Inorg. Perspectives in Biol. and Med. 2:151–180.

    Google Scholar 

  108. Lerch, K., 1981. Metal Ions Biol. Syst. 13:143–186.

    Google Scholar 

  109. Skotland, T., andFlatmark, T., 1979. J. Neurochem. 32:1861–1863.

    Google Scholar 

  110. Boyadjian, A. S., Nalbandyan, R. M., andBuniatian, H. Ch., 1981. Biochimia, (Russ.) 46:635–641.

    Google Scholar 

  111. Walker, G. A., Kon, H., andLovenberg, W., 1977. Biochim. Biophys. Acta 482:309–322.

    Google Scholar 

  112. Skotland, T., Petersson, L., Backström, D., Ljones, T., Flatmark, T., andEhrenberg, A., 1980. Europ. J. Biochem. 10:5–11.

    Google Scholar 

  113. Bouclier, M., Pescheloche, M., Mandell, P., andAunis, D., 1978. Biochimie 60:127–136.

    Google Scholar 

  114. Boyadjian, A. S., andNalbandyan, R. M., 1982. Biochem. Biophys. Res. Comms. 106:1248–1256.

    Google Scholar 

  115. Mehrabyan, Z. B., andNalbandyan, R. M., FEBS-Letters, in press.

  116. Lai, F. M., Udenfriend, S., andSpector, S., 1975. Proc. Natl. Acad. USA 72: 4622–4625.

    Google Scholar 

  117. Jarrott, B., Bjelle, J. T., andSpector, S., 1979. Brain Res. 168:323–330.

    Google Scholar 

  118. Iu, C., Iu, L., andKing, T. E., 1975. J. Biol. Chem. 250:1383–1392.

    Google Scholar 

  119. Nalbandyan, R. M., 1979. Voprosi Biochimii Mozga (Russ.) 13:79–85.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biochemistry Academy of Sciences, Armenian SSR, 375044, Yerevan, USSR

    R. M. Nalbandyan

Authors
  1. R. M. Nalbandyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This paper is dedicated to the memory of Professor H.Ch. Buniatian

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nalbandyan, R.M. Copper in brain. Neurochem Res 8, 1211–1232 (1983). https://doi.org/10.1007/BF00963993

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00963993

Keywords

Search

Navigation