Skip to main content
SpringerLink
Log in

Experimental Animal Models for Studying Antimicrobial Pharmacokinetics in Otitis Media

  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

Abstract

Antimicrobial treatment of otitis media, especially drug dosing considerations, is largely empiric, with few reported pharmacologic studies of drug distribution into the middle ear. A chinchilla animal model of serous and purulent otitis media has been used for some time to investigate mechanisms of disease pathogenesis. This model was adapted to investigate the penetration of amoxicillin, trimethoprim, and sulfamethoxazole into middle ear effusion. Purulent otitis media was produced by direct middle ear inoculation with type 7F Streptococcus pneumoniae. Serous otitis media was produced by eustachian tube obstruction using silastic sponge or Coeflex cement, but the Coeflex caused an undesirable local inflammatory response. The three antibiotics were administered to chinchillas with serous and purulent middle ear effusion. Plasma and ear fluid drug concentrations were measured by liquid chromatography and demonstrated the value of this model in assessing antibiotic penetration.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

REFERENCES

  1. G. S. Giebink and D. M. Canafax. In S. C. Aronoff, W. T. Hughes, S. Kohl, N. T. Speck, and E. R. Wald (eds.), Advances in Pediatric Infectious Diseases, Year Book Medical, Chicago, Vol. 3, 1988.

    Google Scholar 

  2. G. S. Giebink, W. L. Meyerhoff, and E. I. Cantekin. In Experimental Models in Antimicrobial Chemotherapy, Vol. 1, Academic Press, London, 1986, pp. 213–36.

    Google Scholar 

  3. G. S. Giebink. Rev. Infect. Dis. 3:342–352 (1981).

    Google Scholar 

  4. G. S. Giebink. Infect. Immunol. 41:913–920 (1983).

    Google Scholar 

  5. G. S. Giebink, R. A. Heller, and E. R. Harford. Ann. Otol. Rhinol. Laryngol. 91:20–24 (1982).

    Google Scholar 

  6. T. T. K. Jung, S.-J. Hwang, D. Pool, et al. In D. J. Lim (ed.), Recent Advances in Otitis Media, B. C. Decker, Philadelphia, 1988.

    Google Scholar 

  7. M. L. Ripley-Petzoldt and G. S. Giebink. J. Infect. Dis. 157:245–255 (1988).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University of Minnesota Otitis Media Research Center, University of Minnesota, Minneapolis, Minnesota, 55455

    Daniel M. Canafax, Naobumi Nonomura, Gary R. Erdmann, Chap T. Le, Steven K. Juhn & G. Scott Giebink

  2. Department of Pharmacy Practice, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, 55455

    Daniel M. Canafax & Gary R. Erdmann

  3. Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, Minnesota, 55455

    Steven K. Juhn & G. Scott Giebink

  4. Department of Otolaryngology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, 55455

    G. Scott Giebink

  5. Biometry Division, School of Public Health, University of Minnesota, Minneapolis, Minnesota, 55455

    Chap T. Le

  6. Department of Otolaryngology, Niigata University School of Medicine, Niigata, Japan

    Naobumi Nonomura

Authors
  1. Daniel M. Canafax
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Naobumi Nonomura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gary R. Erdmann
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Chap T. Le
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Steven K. Juhn
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. Scott Giebink
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Canafax, D.M., Nonomura, N., Erdmann, G.R. et al. Experimental Animal Models for Studying Antimicrobial Pharmacokinetics in Otitis Media. Pharm Res 6, 279–285 (1989). https://doi.org/10.1023/A:1015938205892

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1015938205892

Search

Navigation