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Mucoadhesion of Copolymers and Mixtures Containing Polyacrylic Acid

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Abstract

Water-soluble polymers were synthesized from dextran and polyacrylic acid and their ocular mucoadhesion was evaluated. One series had polyacrylic acid grafted onto the polysaccharide backbone of dextran, and another series had dextran grafted onto the polyacrylic acid backbone. Mucoadhesion of these copolymers was investigated using a tensile apparatus and compared with that of polyacrylic acid/dextran mixtures prepared in different proportions. Whatever the copolymer structure, no synergistic effects were seen and mucoadhesion was not markedly increased compared to dextran. The adhesion of copolymers was the same as that of mixtures having a similar polyacrylic acid content and was always less than that of polyacrylic acid alone. Formation of an interpolymer complex occurred at concentrations up to 60% polyacrylic acid, and only above this value did bioadhesion increase above that of dextran. When this complex was dissociated by neutralization of the carboxyl groups of polyacrylic acid, the mucoadhesion of the copolymers and the mixtures was improved. These experiments demonstrated that copolymers and mixtures of dextran and polyacrylic acid did not produce polymers with improved ocular mucoadhesion.

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Authors and Affiliations

  1. Centre de Recherche, Merck, Sharp and Dohme-Chibret, 63203, Riom, France

    Florence Thermes, Jeffrey Grove, Annouk Rozier & Bernard Plazonnet

  2. Laboratoire de Chimie Macromoléculaire-, Université P. et M. Curie, URA CNRS 24, 4, Place Jussieu, Paris Cedex, 05, France

    Alain Constancis, Claude Bunel & Jean-Pierre Vairon

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  1. Florence Thermes
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  2. Jeffrey Grove
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  4. Bernard Plazonnet
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  5. Alain Constancis
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Thermes, F., Grove, J., Rozier, A. et al. Mucoadhesion of Copolymers and Mixtures Containing Polyacrylic Acid. Pharm Res 9, 1563–1567 (1992). https://doi.org/10.1023/A:1015856223252

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