Abstract
Assignment of human genes coding for α-fucosidase (αFUC) and glucose dehydrogenase (GDH) to chromosome 1 has been confirmed and a location in the p21→pter region demonstrated using man-mouse somatic cell hybrids. The regional location af αFUC andGDH was established in cell hybrids using human cells possessing 1/2 translocation chromosomes [46,XX,t(1;2)(p21;q37)]. Hybrids which retained the 2q+ chromosome carrying the 1p21→1pter region concordantly expressed αFUC, GDH, and the short-arm markers ENO1, AK2, and PGM1. Hybrids which retained the 1p21→1qter region only expressed human PEPC and FH. Data obtained from hybrids in which spontaneous breaks in chromosome 1 had occurred indicate that the gene order in 1p21ar1pter is (ENO1,GDH)-αFUC-AK2-PGM1.
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Turner, B. M., Turner, V. S., Beratis, N. G., and Hirschhorn, K. (1975).Am. J. Hum. Genet. 27:651.
Turner, B. M., Beratis, N. G., Turner, V. S., and Hirschhorn, K. (1974).Clin. Chim. Acta 57:29.
Turner, V. S., Turner, B. M., Kucherlapati, R., Ruddle, F. H., and Hirschhorn, K. (1976).Birth Defects: Orig. Artic. Ser. 12:238–240.
Hameister, H., Ropers, H.-H., and Grzeschik, K.-H. (1978).Birth Defects: Orig. Artic. Ser., in press.
Harris, H., and Hopkinson, D. A. (1976).Handbook of Enzyme Electrophoresis in Human Genetics (American Elsevier, New York).
Shows, T. B., and Brown, J. A. (1975).Birth Defects: Orig. Artic. Ser. 11:251–255.
Lalley, P. A., Brown, J. A., Eddy, R. L., Haley, L. L., Byers, M. G., Goggin, A. P., and Shows, T. B. (1977).Biochem. Genet. 15:357.
Rattazzi, M. C., Brown, J. A., Davidson, R. G., and Shows, T. B. (1976).Am. J. Hum. Genet. 28:143.
Shows, T. B., Brown, J. A., Haley, L. L., Byers, M. G., Eddy, R. L., Cooper, E. S., and Goggin, A. P. (1978).Cytogenet. Cell Genet., in press.
Champion, M. J., and Shows, T. B. (1977).Proc. Natl. Acad. Sci. U.S.A. 74:2968.
Shows, T. B., and Brown, J. A. (1975).Proc. Natl. Acad. Sci. U.S.A. 72:2125.
Goss, S. J., and Harris, H. (1977).J. Cell Sci. 25:17.
Corney, G., Fisher, R. A., Cook, P. J. L., Noades, J., and Robson, E. B. (1977).Ann. Hum. Genet. London 40:403.
Marsh, W. L., Chaganti, R. S. K., Gardner, F. H., Mayer, K., Nowell, P. C., and German J. (1974).Science 183:966.
D'Ancona, G. G., Chern, C. J., Benn, P., and Croce, C. M. (1977).Cytogenet. Cell Genet. 18:309.
Francke, U., and George, D. (1978).Birth Defects: Orig. Artic. Ser., in press.
Jongsma, A. P. M., and Burgerhout, W. G. (1977).Cytogenet. Cell Genet. 18:255.
Fisher, R. A., Noades, J. E., and Robson, E. B. (1978).Birth Defects: Orig. Artic. Ser., in press.
Burgerhout, W. G., Leupe-de Smit, S., and Jongsma, A. P. M. (1978).Birth Defects: Orig. Artic. Ser., in press.
Koch, G. A., Brown, J. A., and Shows, T. B. (1978).Birth Defects: Orig. Artic. Ser., in press.
Burgerhout, W. G., and Cook, P. J. L. (1978).Birth Defects: Orig. Artic. Ser., in press.
Lalley, P. A., Rattazzi, M. C., and Shows, T. B. (1974).Proc. Natl. Acad. Sci. U.S.A. 71:1569.
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Koch, G.A., Brown, J.A. & Shows, T.B. Gene assignment of α-fucosidase and glucose dehydrogenase to the p21→pter region of chromosome 1 in man. Somat Cell Mol Genet 4, 313–321 (1978). https://doi.org/10.1007/BF01542845
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DOI: https://doi.org/10.1007/BF01542845