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Steric vs. electrostatic effects in the nucleophilic addition to a hindered cyclohexanone

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Abstract

The relative importance of steric vs. electrostatic effects in the nucleophilic addition to (4R,6S)-4-(tert-butyldimethylsiloxy)-2,2,6-trimethylcyclohexanone (1), a well-known chiral building block, is investigated.

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Authors and Affiliations

  1. Institut für Organische Chemie der UniversitÄt Basel, CH-4056, Basel, Switzerland

    Joachim Busch & Urs Séquin

  2. Department of Chemical Information Technology, Technical University of Budapest, POB 91, H-1521, Budapest, Hungary

    György M. Keserü & Zoltán Kovári

Authors
  1. Joachim Busch
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  2. György M. Keserü
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  3. Zoltán Kovári
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  4. Urs Séquin
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Busch, J., Keserü, G.M., Kovári, Z. et al. Steric vs. electrostatic effects in the nucleophilic addition to a hindered cyclohexanone. Struct Chem 8, 257–261 (1997). https://doi.org/10.1007/BF02252969

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  • DOI: https://doi.org/10.1007/BF02252969

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