Summary
Virilizing arrhenoblastoma obtained from a 20-year-old woman has been incubatedin vitro with progesterone-4-C14. Conversion to 17 α-hydroxy-progesterone, Δ4-androstene-3,17-dione, and at least two more polar substances has been demonstrated.
Literatur
Anliker, R., O. Rohr u.L. Ruzicka: Justus Liebigs An. Chem.602, 109 (1957).
Baggett, B., L. L. Engel, K. Savard andR. I. Dorfman: J. biol. Chem.221, 931 (1956).
Lynn jr., W. S., andR. H. Brown: J. biol. Chem.232, 1015 (1958).
Savard, K., R. I. Dorfman, R. Baggett andL. L. Engel: J. clin. Endocr.16, 1629 (1957).
Savard, K., R. I. Dorfman, J. L. Gabrilove andL. J. Soffer: 39th Meeting of the Endocrine Society, New York, N.Y., 1957. Abstracts of papers p. 133.
Slaunwhite jr., W. R., andL. T. Samuels: J. biol. Chem.220, 341 (1956).
Solomon, S., R. Vande Wiele andS. Lieberman: J. Amer. chem. Soc.78, 5453 (1956).
Viscelli, T. A., M. E. Lombardo andP. B. Hudson: Fed. Proc.16, 265 (1957).
Wiest, W. G., J. Zander andE. G. Holmstrom: J. clin. Endocr. (im Druck).
Wotiz, H. H., J. W. Davis, H. W. Lemon andM. Gut: J. biol. Chem.222, 487 (1956).
Zander, J.: J. biol. Chem.232, 117 (1958).
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Durchgeführt mit Unterstützung des National Institutes of Health, United States Public Health Service, Bethesda 14, Maryland, USA.
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Wiest, W.G., Zander, J. & Holmstrom, E.G. Stoffwechsel von Progesteron-4-C14 im Arrhenoblastom. Klin Wochenschr 37, 45–46 (1959). https://doi.org/10.1007/BF01483185
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DOI: https://doi.org/10.1007/BF01483185