Zusammenfassung
Stop-flow-Untersuchungen an sechs Hunden ergaben nach i.v.-Applikation von 1 mg/kg Körpergewicht Fursemid eine starke Hemmung der proximalen und distalen Wasser- sowie Natriumrückresorption und eine gesteigerte distale Kaliumsekretion. Im Vergleich zu Quecksilberdiuretica bestand ein unterschiedlicher Effekt im proximalen und distalen Tubulus.
Summary
The action of Fursemide, a new anthranylic acid derivative with diuretic response was studied by stop-flow analysis in six dogs. Fursemide exerted within twenty minutes a marked inhibition of proximal and distal water-and sodium reabsorption as well as a mild distal potassium secretion.
In two experiments stop-flow pattern was studied following the application of mercury-allyl-theobromine and compared with the pattern obtained by subsequent Fursemide injection. Data indicate an additive Fursemide effect on the proximal tubule and a distal effect not observed by mercury application.
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Lasix® der Farbwerke Hoechst, Frankfurt a. M.
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Suzuki, F., Klütsch, K. & Heidland, A. Stop-flow-Untersuchungen zum Wirkungsmechanismus von Fursemid. Klin Wochenschr 42, 569–571 (1964). https://doi.org/10.1007/BF01487784
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DOI: https://doi.org/10.1007/BF01487784