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Immunpathologische Begleiterkrankungen und -phänomene des Lupus erythematodes

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Zusammenfassung

Über immunpathologische Begleiterkrankungen und -phänomene beim LED wird anhand eines Falles von LED und Myasthenia gravis (33jährige Patientin), 2 Fällen von LED und Thyreoiditis (42- bzw. 35jährige Patientinnen) und 7 bzw. 13 weiteren LED-Patienten berichtet. — Von 4 LED-Patienten mit positiven Rheumafaktoren waren 3 aus einer chronischen Polyarthritis rheumatica hervorgegangen. — Die nachgewiesenen Leuko- bzw. Thrombocytenagglutinine bei 3 bzw. 2 Patienten traten in 2 Fällen im Sinne autoantikörperbedingter Cytopenien kombiniert auf. — Faktoren gegen speciesunspezifische cytoplasmatische Fraktionen von Ratten-und Schweineleber waren mit der KBR nur in einem Falle unter Verwendung der Mikrosomen bzw. Mitochondrienfraktion als Antigen nachweisbar. — Die Schilddrüsenantikörper waren in dem einen Fall gegen menschliches Thyreoglobulin, im anderen Fall gegen die Mikrosomenfraktionen gesunder und kranker menschlicher Schilddrüsen sowie Thyreoglobulin einer Kolloidstruma gerichtet. — Die seltene Beobachtung eines LED, kombiniert mit Myasthenia gravis war Anlaß, die Beziehungen von Autoimmunleiden zur Thymusfunktion zu diskutieren.

Summary

One case of LED and myastenia gravis (Patient aged 33 years), two cases of LED and Thyroiditis (patients aged 42 and 35 years), and immunopathological phenomena of 13 patients with LED were reported. — 3 of 4 patients with LED and positive rheumatoid factors had in the preclinical phase of LED a history of rheumatoid arthritis. — There are leukocytagglutinins in 3 and plateletagglutinins in 2 patients. Both agglutinins were present in these patients. The cytopenia therefore seemed to be caused by autoantibodies. — Factors against species-unspecific cytoplasmatic fractions of rat and pig liver were found by complement fixation-test only in one case using the microsome and mitochondria fractions as antigen. — Thyroid-antibodies were directed against human thyreoglobulin in one case, and against the microsome fractions of normal and pathological human thyroid as well as thyreoglobulin of colloid goitre in another one. — The rare observation of LED and myastenia gravis gave rise to the discussion of the relation between autoimmun diseases and thymus function.

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Author information

Authors and Affiliations

  1. Aus der II. Medizinischen Universitätsklinik und Poliklinik Mainz, Germany

    K. H. Meyer zum Büschenfelde, A. Gamp & F. Schilling

  2. der Klinik für Rheumakranke Bad Kreuznach, Germany

    K. H. Meyer zum Büschenfelde, A. Gamp & F. Schilling

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  1. K. H. Meyer zum Büschenfelde
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  2. A. Gamp
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  3. F. Schilling
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Herrn Prof.Voit zum 70. Geburtstag gewidmet.

Die Untersuchungen wurden mit Unterstützung der Deutschen Forschungsgemeinschaft ausgeführt.

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Meyer zum Büschenfelde, K.H., Gamp, A. & Schilling, F. Immunpathologische Begleiterkrankungen und -phänomene des Lupus erythematodes. Klin Wochenschr 43, 892–898 (1965). https://doi.org/10.1007/BF01711255

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