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Embryonale Hämoglobine

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Zusammenfassung

Die vonHuehns u. Mitarb. genauer beschriebenen embryonalen Blutfarbstoffe Gower 1 und Gower 2 ließen sich im Hämolysat des Blutes einer 5,5 cm langen menschlichen Frucht durch die Stärkegelelektrophorese nachweisen. Sie fanden sich außerdem auf der Photographie einer Stärkeblockelektrophorese aus dem Jahre 1960 von Hämolysat einer 3,5 cm langen menschlichen Frucht. Im Blut eines 1 cm langen Rinderembryo wurden neben fetalem Rinder-Hb drei langsam wandernde Hb-Fraktionen festgestellt, die offensichtlich ebenfalls als embryonale Hämoglobine anzusehen sind.

Summary

Recent work byHuehns et al. gives good evidence that the two prefoetal blood pigments Gower 1 and Gower 2 are normal hemoglobins in the early development of human embryos. These two embryonic hemoglobins with a slow anodic mobility similar to HbC are regulary detected in embryos with a crown-rump length under 10 cm. Chemical properties, polypeptide chain composition and occurrence in the newborn are dicussed by the authors.

In this paper the existence of human embryonic hemoglobin is confirmed by starch-gel electrophoresis in blood samples of four young embryos with a crown-rump length ranging from 2.5 to 5.5 cm. In comparative studies embryonic hemoglobins were also found in cow embryos with a crown-rump length between 1 and 7 cm.

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Literatur

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Authors and Affiliations

  1. Aus der Kinderklinik und der Frauenklinik der Universität Tübingen, Germany

    E. Kleihauer, K. Betke & P. -A. König

Authors
  1. E. Kleihauer
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  2. K. Betke
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  3. P. -A. König
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Mit Unterstützung durch die Deutsche Forschungsgemeinschaft.

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Kleihauer, E., Betke, K. & König, P.A. Embryonale Hämoglobine. Klin Wochenschr 43, 435–437 (1965). https://doi.org/10.1007/BF01483849

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  • DOI: https://doi.org/10.1007/BF01483849

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