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Lysozyme Ergebnisse und Probleme

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Zusammenfassung

Es wird versucht, aus Untersuchungsergebnissen eigener Experimente, und aus literarischen Studien, einen Überblick über die heutigen Kenntnisse der biologischen, diagnostischen und therapeutischen Bedeutung von Lysozymen zu geben. Nach kurzen Angaben über Vorkommen, über den chemischen Aufbau, sowie über Reinigungs-, Isolierungs-und Nachweismethoden verschiedener Lysozyme werden die biologischen Eigenschaften (Antigenität, Enzymaktivität, Polykationwirkung, Phagocytose- und Pyrogenitäts-beeinflussung) dieser Substanzen behandelt. Dabei wird auf die Problematik zahlreicher Wechselwirkungen zwischen Lysozym und anderen biologisch aktiven Stoffen eingegangen. Zum Schluß wird kurz auf die diagnostische und therapeutische Bedeutung von Lysozym bei bestimmten Erkrankungen des Menschen hingewiesen.

Summary

A review of the recent developments (literature and own investigations) in the study of lysozymes is given in the paper. After a short resumé of the lysozyme content of different tissues, fluids etc., the chemical structure, methods of purification, isolation and determination of several lysozymes, the biological properties of these substances (antigenic nature, enzyme activity, polycationeffects, the influence on phagocytosis and pyrogenicity) will be considered. Then the problems of the correlations between lysozyme and other biologically active substances will be discussed. And lastly the role of lysozyme as an aid in the diagnosis and treatment of human diseases deserves mention.

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Grossgebauer, K., Langmaack, H. Lysozyme Ergebnisse und Probleme. Klin Wochenschr 46, 1121–1127 (1968). https://doi.org/10.1007/BF01712950

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