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Wirkung eines heterologen Antilymphocytenserums auf die experimentelle allergische Encephalomyelitis

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Zusammenfassung

Die Wirkung eines heterologen Antilymphocytenserums (ALS) vom Kaninchen auf die experimentelle allergische Encephalomyelitis (EAE) wurde in Versuchen an Sprague-Dawley-Ratten geprüft.

Durch eine ALS-Verabreichung, die vor, gleichzeitig mit, oder auch erst nach der Sensibilisierung eingeleitet wurde, konnte die EAE bei allen Versuchstieren vollkommen unterdrückt werden. Bereits aufgetretene Lähmungserscheinungen bildeten sich in 90% der Fälle unter ALS-Behandlung zurück.

Die im Vergleich zu anderen gebräuchlichen immunsuppressiven Maßnahmen besonders gute Wirkung von ALS auf die bereits ausgebrochene experimentelle Autoimmunerkrankung sowie mögliche Angriffspunkte von ALS in der pathogenetischen Entwicklung der EAE werden abschließend diskutiert.

Summary

The effect of a heterologous rabbit anti-lymphocyte serum (ALS) on the experimental allergic encephalomyelitis (EAE) was tested in Sprague Dawley rats:

EAE could be completely suppressed if ALS was given either before, simultaneously with, or after sensitization in all animals. The paralysis already developed could be abolished by ALS in 90%.

In comparison to other common immunosuppressive agents, the strong effect of ALS after the manifestation of the autoimmune disease as well as the possible sites of action of ALS during the pathogenesis of EAE are finally discussed.

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Authors and Affiliations

  1. Institut für Experimentelle Chirurgie der Chirurgischen Klinik und Nervenklinik der Universität München, Germany

    W. Land, E. Frick, R. Roscher, W. Brendel & A. Baethmann

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  1. W. Land
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  2. E. Frick
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  3. R. Roscher
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  4. W. Brendel
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  5. A. Baethmann
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Auszugsweise vorgetragen auf der 85. Tagung der Deutschen Gesellschaft für Chirurgie, München, April 1968.

Mit Unterstützung durch die Deutsche Forschungsgemeinschaft.

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Land, W., Frick, E., Roscher, R. et al. Wirkung eines heterologen Antilymphocytenserums auf die experimentelle allergische Encephalomyelitis. Klin Wochenschr 47, 633–640 (1969). https://doi.org/10.1007/BF01884358

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