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Untersuchungen zur Wirkung von Antilymphocytenglobulin bei der experimentellen allergischen Encephalomyelitis des Meerschweinchens

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Zusammenfassung

Die EAE des Meerschweinchens wurde mit ALG von Kaninchen behandelt, dessen cytotoxischer Titer 1:256 betrug. Mit den ALG-Injektionen wurde am Tag nach der Sensibilisierung mit homologem Hirnextrakt begonnen. Die Seruminjektionen erfolgten in zweitägigem Abstand über drei Wochen. Durch die ALG-Injektionen konnten schwere Formen der EAE regelmäßig verhindert werden; leichte Fälle von EAE traten in 33% der Fälle auf. Untersuchungen mit dem LTT zeigten eine deutliche Verminderung der Transformationsfähigkeit der Lymphocyten von ALG behandelten Meerschweinchen nach Zugabe von spezifischen und unspezifischen Stimulatien.

Summary

The EAE of the guinea pig was treated by injections of ALG from the rabbit. The first ALG-injection was administered on the day after the sensitizing injection of homologous brain extract. The ALG treatment was continued over three weeks in two day intervals.

In the ALG injected animals severe EAE was not observed, in 33% a moderate EAE could be histologically demonstrated. In the ALG treated animals the capacity of lymphocytes to transform to blast cells by specific or unspecific stimulation was decreased in comparison to the controls treated with normal rabbit serum.

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Authors and Affiliations

  1. Abteilung für Klinische Immunologie des Universitätskrankenhauses Erlangen-Nürnberg, Germany

    H. Warnatz, F. Scheiffarth & A. Scheder

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  1. H. Warnatz
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  2. F. Scheiffarth
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  3. A. Scheder
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Die Arbeit wurde mit Unterstützung der Deutschen Forschungsgemeinschaft ausgeführt. (Az Sch 36/8).

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Warnatz, H., Scheiffarth, F. & Scheder, A. Untersuchungen zur Wirkung von Antilymphocytenglobulin bei der experimentellen allergischen Encephalomyelitis des Meerschweinchens. Klin Wochenschr 48, 696–698 (1970). https://doi.org/10.1007/BF01493819

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  • DOI: https://doi.org/10.1007/BF01493819

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