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Dünndarm-Saugbiopsie im Kindesalter: Technik, Komplikationen, Bedeutung für die Diagnose intestinaler Erkrankungen

Small intestine suction biopsy in childhood: Technique, complications, and significance in the diagnosis of intestinal disorders

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Summary

Special modifications of biopsy instruments have been developed for peroral intestinal biopsy in children. The risk of intestinal hemorrhage or perforation is low with a proved method, and biopsy is justified in any of the case where it is indicated. As the procedure requires only a short time it is not too annoying for the children. The investigation of small intestinal biopsy specimens is of great diagnostic value in coeliac disease, disaccharide-intolerance and other rare forms of malabsorption.

Zusammenfassung

Für die Dünndarmbiopsie im Kindesalter wurden besondere Ausführungen einiger Instrumente entwickelt. Das Risiko einer Darmblutung oder -perforation ist mit den bewährten Verfahren sehr gering und kann bei entsprechender Indikation vertreten werden. Der Eingriff läßt sich in kurzer Zeit durchführen und ist für die Kinder zumutbar. Die Untersuchungsmethode hat Bedeutung bei der Diagnose einer Cöliakie, einer Disaccharid-Intoleranz sowie einigen selteneren Formen der Malabsorption.

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Literatur

  1. Ammann, R.: Celiac and celiac-like mucosal changes of the small intestine. Gastroenterologia (Basel)103, 295 (1965).

    Google Scholar 

  2. Anderson, C. M.: Histological changes in the duodenal mucosa in coeliac disease. Reversibility during treatment with a wheat gluten free diet. Arch. Dis. Childh.35, 419 (1960).

    Google Scholar 

  3. —— Intestinal malabsorption in childhood. Arch. Dis. Childh.41, 571 (1966).

    Google Scholar 

  4. —— Burke, V., Messer, M., Kerry, K. R.: Sugar intolerance and coeliac disease. Lancet1966 I, 1322.

    Google Scholar 

  5. Auricchio, S., Rubino, A., Tosi, R., Semenza, G., Landolt, M., Kistler, H., Prader, A.: Disaccharidase activities in human intestinal mucosa. Enzym. biol. clin.3, 193 (1963).

    Google Scholar 

  6. Aust, C. H., Smith, E. B.: Whipple's disease in a 3-month-old infant, with involvement of bone marrow. Amer. J. clin. Path.37, 66 (1962).

    Google Scholar 

  7. Bach, C., Polonovski, J., Polonovski, C., Leluc, R., Jolly, G., Moszer, M.: L'absence congenitale de beta-lipoproteines. Une nouvelle observation. Arch. franç. Pédiat.24, 1093 (1967).

    Google Scholar 

  8. Baker, S.J., Hughes, A.: Multiple-retrieving small-intestinal biopsy tube. Lancet1960 II, 686.

    Google Scholar 

  9. Brandborg, L. L., Rubin, C. E., Quinton, W. E.: A multipurpose instrument for suction biopsy of the oesophagus, stomach, small bowel and colon. Gastroenterology37, 1 (1959).

    Google Scholar 

  10. Bremer, H. J.: Die gluteninduzierte Enteropathie (Zöliakie) bei Kindern. Med. Klin.64, 519 (1969).

    Google Scholar 

  11. Bruni, R., Massimo, L.: Descrizione di un rarissimo caso di malattia di Whipple nell' età pediatrica. Minerva pediat.11, 935 (1959).

    Google Scholar 

  12. Brunt, P. W., Sircus, W., Maclean, N.: Neoplasia and the coeliac syndrome in adults. Lancet1969 I, 180.

    Google Scholar 

  13. Burman, D., Morrison, G. D.: Jejunal biopsy in childhood. Brit. med. J.1963 II, 1410.

    Google Scholar 

  14. Cameron, A. H., Astley, R., Hallowell, M., Rawson, A. B., Miller, C. G., French, J. M., Hubble, D. V.: Duodenojejunal biopsy in the investigation of children with coeliac disease. Quart. J. Med.31, 125 (1962).

    Google Scholar 

  15. Choudhury, D. C. R., Nicholson, G. I., Cooke, W. T.: Simple capsule for multiple intestinal biopsy specimens. Lancet1964 II, 185.

    Google Scholar 

  16. Classen, M., Koch, H.: Perorale Dünndarmbiopsie. Modifikation und Vereinfachung der Technik. Dtsch. med. Wschr.93, 2203 (1968).

    Google Scholar 

  17. Cook, D. M., Evans, N., Lloyd, A., Stewart, J. S.: Normal serum and red-cell folate levels in a child with coeliac disease. Lancet1970 I, 571.

    Google Scholar 

  18. Crosby, W. H., Kugler, H. W.: Intraluminal biopsy of the small intestine. The intestinal biopsy capsule. Amer. J. dig. Dis.2, 236 (1957).

    Google Scholar 

  19. Dahlqvist, A.: Assay of intestinal disaccharidases. Analyt. Biochem.22, 99 (1968).

    Google Scholar 

  20. Demling, L., Ottenjann, R., Elster, K.: Die Gastrobiopsie. Ergebn. inn. Med. Kinderheilk. (N.F.)27, 32 (1968).

    Google Scholar 

  21. Dobbins, W. O., III, Trier, J. S., Parkins, R. A., MacDonald, W. C., Ways, P., Barett, B., Rubin, C. E.: A warning regarding the dangers of hydraulic biopsy in gastrointestinal research. Gastroenterology45, 335 (1963).

    Google Scholar 

  22. Eggermont, E.: The hydrolysis of the naturally occurring alpha-glucosides by the human intestinal mucosa. Europ. J. Biochem.9, 483 (1969).

    Google Scholar 

  23. —— The genetics of intestinal carbohydrate intolerance. Progress in medical genetics, vol. 6, p. 241. New York and London: Grune & Stratton 1969.

    Google Scholar 

  24. Flick, A. L., Quinton, W. E., Rubin, C. E.: A peroral hydraulic biopsy tube for multiple sampling at any level of the gastrointestinal tract. Gastroenterology40, 120 (1961).

    Google Scholar 

  25. Freye, H. B., Kurtz, S. M., Spock, A., Capp, M. P.: Light and electron microscopic examination of the small bowel of children with cystic fibrosis. J. Pediat.64, 575 (1964).

    Google Scholar 

  26. Gibbons, I. S. E.: Disaccharides and cystic fibrosis of the pancreas. Arch. Dis. Childh.44, 63 (1969).

    Google Scholar 

  27. Grüttner, R.: The nonspecific effect of a glutenfree diet in steatorrhea of children (abstr.). Acta paediat. scand.58, 312 (1969).

    Google Scholar 

  28. Guha, D. K., Walia, B. N. S., Tandon, B. N., Deo, M. G., Ghai, O. P.: Small bowel changes in iron-deficiency anaemia of childhood. Arch. Dis. Childh.43, 239 (1968).

    Google Scholar 

  29. Hamilton, J. R., Lynch, M. J., Reilly, B. J.: Active coeliac disease in childhood. Clinical and laboratory findings of 42 cases. Quart. J. Med.38, 135 (1969).

    Google Scholar 

  30. Harris, M. J., Harrington, G., Beveridge, J.: Modification to the technique for small bowel biopsy in children including the use of metoclopramide. Amer. J. Dis. Child.115, 43 (1968).

    Google Scholar 

  31. Harris, O. D., Cooke, W. T., Thompson, H., Waterhouse, J. A. H.: Malignancy in adult coeliac disease and idiopathic steatorrhea. Amer. J. Med.42, 899 (1967).

    Google Scholar 

  32. Hendrix, T. R.: Interpretation of intestinal biopsies. Gastroenterology54, 976 (1968).

    Google Scholar 

  33. Herbst, J. J., Sunshine, P., Kretchmer, N.: Intestinal malabsorption in infancy and childhood. Advanc. Pediat.16, 11 (1969).

    Google Scholar 

  34. Hide, D. W., Burman, D.: An infant with both cystic fibrosis and coeliac disease. Arch. Dis. Childh.44, 533 (1969).

    Google Scholar 

  35. Hindle, W., Creamer, B.: Significance of a flat small-intestinal mucosa. Brit. med. J.1965 II, 455.

    Google Scholar 

  36. Holmes, R., Hourihane, D. O'B., Booth, C. C.: Dissecting-microscope appearances of jejunal biopsy specimens from patients with “idiopathic steatorrhea”. Lancet1961 I, 81.

    Google Scholar 

  37. Holzel, A.: Sugar malabsorption due to deficiencies of disaccharidase activities and of monosaccharide transport. Arch. Dis. Childh.42, 341 (1967).

    Google Scholar 

  38. Hooft, C., Devos, E., Kriekemans, J., Damme, J. van: Malabsorption and diabetes mellitus in children. Helv. paediat. Acta23, 478 (1968).

    Google Scholar 

  39. Hubble, D.: Diagnosis and management of coeliac disease in childhood. Brit. med. J.1963 II, 701.

    Google Scholar 

  40. Jeffries, G. H., Weser, E., Sleisenger, M. H.: Malabsorption. Gastroenterology56, 777 (1969).

    Google Scholar 

  41. Jos, J., Rey, J., Frézal, J., Nézelof, C., Lamy, M.: La biopsie intestinale chez l'enfant. Arch. franç. Pédiat.24, 1159 (1967).

    Google Scholar 

  42. —— —— —— Effects precoces de la reintroduction du gluten sur la muqueuse intestinale dans la maladie coeliaque en remission. Arch. franç. Pédiat.26, 849 (1969).

    Google Scholar 

  43. Kasper, H.: Methoden zur Diagnostik von Dünndarmerkrankungen. Med. Klin.64, 1149 (1969).

    Google Scholar 

  44. Kauder, E., Bayless, T. M.: Peroral intestinal biopsy of the small intestine. A technique. Amer. J. Dis. Child.107, 582 (1964).

    Google Scholar 

  45. Klipstein, F. A.: Tropical sprue. Gastroenterology54, 275 (1968).

    Google Scholar 

  46. Kuitunen, P., Visakorpi, J. K., Hallman, N.: Histopathology of duodenal mucosa in malabsorption syndrome induced by cow's milk. Ann. paediat. (Basel)205, 54 (1965).

    Google Scholar 

  47. Latham, S.: Further modifications in the children's jejunal biopsy capsule. Brit. med. J.1969 I, 243 (b).

    Google Scholar 

  48. Launiala, K.: The mechanism of diarrhoea in congenital disaccharide malabsorption. Acta paediat. scand.57, 425 (1968).

    Google Scholar 

  49. Lindberg, T.: Studies on intestinal dipepdidases (abstr.). Acta paediat. scand.58, 305 (1969).

    Google Scholar 

  50. Lindenbaum, J., Kent, T. H., Sprinz, H.: Malabsorption and jejunitis in American Peace Corps volunteers in Pakistan. Ann. intern. Med.65, 1201 (1966).

    Google Scholar 

  51. MacDonald, W. C., Brandborg, L. L., Flick, A. L., Trier, J. S., Rubin, C. E.: Studies of celiac sprue. IV. The response of the whole length of the small bowel to a gluten-free diet. Gastroenterology47, 573 (1964).

    Google Scholar 

  52. Mařatka, Z., Šetka, J.: Einfache Methode zur Magen-und Darmbiopsie. Gastroenterologia (Basel)102, 369 (1964).

    Google Scholar 

  53. Mathan, V. I., Joseph, S., Baker, S. J.: Tropical sprue in children. A syndrome of idiopathic malabsorption. Gastroenterology56, 556 (1969).

    Google Scholar 

  54. McCarthy, C. F., Gough, K. R., Rodriguez, M., Read, A. E.: Peroral intestinal mucosal biopsy with a small Crosby capsule. Brit. med. J.1964 I, 1620.

    Google Scholar 

  55. McDonald, W. G.: Perforation and hemorrhage after gastrointestinal mucosal biopsy in a child. Gastroenterology51, 390 (1966).

    Google Scholar 

  56. McNeish, A. S.: Jejunal biopsy in infants and underweight children. Arch. Dis. Childh.42, 623 (1967).

    Google Scholar 

  57. —— Diagnosis of coeliac disease in retrospect. Arch. Dis. Childh.43, 326 (1968).

    Google Scholar 

  58. —— Swect, E. M.: Lactose intolerance in childhood coeliac disease. Assessment of its incidence and importance. Arch. Dis. Childh.43, 433 (1968).

    Google Scholar 

  59. —— Willoughby, M. L. N.: Whole-blood folate as a screening test for coeliac disease in childhood. Lancet1969 I, 442.

    Google Scholar 

  60. McNicholl, B., Egan, B.: Jejunal biopsy in childhood. Brit. med. J.1964 I, 57.

    Google Scholar 

  61. —— —— Jejunal biopsy in celiac disease. Clin. Pediat. (Phila.)7, 544 (1968).

    Google Scholar 

  62. Meeuwisse, G. W., Dahlqvist, A.: Glucose-galaktose malabsorption. A study with biopsy of the small intestinal mucosa. Acta paediat. scand.57, 273 (1968).

    Google Scholar 

  63. —— Experiences with a hydraulic multiple biopsy instrument for peroral intestinal biopsies in children (abstr.). Acta paediat. scand.58, 306 (1969).

    Google Scholar 

  64. Mietens, C.: Untersuchungen über die Antikörperbildung gegen Gliadin und Milchprodukte. Z. Kinderheilk.98, 254 (1967).

    Google Scholar 

  65. —— Vogel, A.: Antikörper gegen Nahrungsproteine und Veränderungen der Dünndarmschleimhaut bei Kindern mit Hepatitis epidemica. Dtsch. med. Wschr.95, 950 (1970).

    Google Scholar 

  66. Mistilis, S. P., Skyring, A. P.: Intestinal lymphangiectasia. Therapeutic effect of lymph venous anastomosis. Amer. J. Med.40, 634 (1966).

    Google Scholar 

  67. Mortimer, P. E., Stewart, J. S., Norman, A. P., Booth, C. C.: Follow-up study of coeliac disease. Brit. med. J.1968 II, 7.

    Google Scholar 

  68. Naiman, J. L., Oski, F. A., Diamond, L. K., Vawter, G. F., Shwachman, H.: The gastrointestinal effects of iron-deficiency anemia. Pediatrics33, 83 (1964).

    Google Scholar 

  69. Nordio, S., Lamedica, G. M., Berio, A., Vignolo, L.: Disaccharidase activities of duodenal mucosa in children. Ann. paediat. (Basel)206, 287 (1966).

    Google Scholar 

  70. -- Persönliche Mitteilung 1969.

  71. Ottenjann, R.: Die perorale Dünndarmbiopsie. Technik und diagnostische Bedeutung. Münch. med. Wschr.108, 31 (1966).

    Google Scholar 

  72. Parfitt, A. M.: Familial neonatal hypoproteinaemia with exsudative enteropathy and intestinal lymphangiectasis. Arch. Dis. Childh.41, 54 (1966).

    Google Scholar 

  73. Partin, J. C., Schubert, W. K.: Precautionary note on the use of the intestinal-biopsy capsule in infants and emaciated children. New Engl. J. Med.274, 94 (1966).

    Google Scholar 

  74. Paulley, J. W.: Observations on the aetiology of idiopathic steatorrhea. Jejunal and lymph-node biopsies. Brit. med. J.1954 II, 1318.

    Google Scholar 

  75. Peller, P., Schaub, J., Zobel, H., Bremer, H. J.: Intestinale Lymphangiektasie. Dtsch. med. Wschr.95, 1219 (1970).

    Google Scholar 

  76. Pink, I. J., Creamer, B.: Response to a gluten-free diet of patients with the coeliac syndrome. Lancet1967 I, 300.

    Google Scholar 

  77. Read, A. E., Gough, K. R., Bones, J. A., McCarthy, C. F.: An improvement to the Crosby peroral intestinal biopsy capsule. Lancet1962 I, 894.

    Google Scholar 

  78. —— Malignancy and steatorrhea. Mod. Probl. Pädiat.11, 182 (1968).

    Google Scholar 

  79. Riecken, E. O., Rosenbaum, R., Bloch, R., Menge, H., Ritt, E., Aslan, M., Dölle, W.: Tierexperimentelle Untersuchungen zur Frage der Spezifität der Dünndarmschleimhautveränderungen bei der einheimischen Sprue. Klin. Wschr.47, 202 (1969).

    Google Scholar 

  80. —— Trojan, H. J., Sauer, H., Martini, G. A.: Diabetische Enteropathie und glutensensitive Enteropathie bei Diabetes mellitus. Internist (Berl.)10, 269 (1969).

    Google Scholar 

  81. Robbe, K., Eckstein, M., Mücke, D., Nitz, I.: Zur Technik der gastro-intestinalen Saugbiopsie im Kindesalter. Dtsch. Gesundh.-Wes.22, 2046 (1967).

    Google Scholar 

  82. Royer, M., Croxatto, O., Biempica, L., Balcázar-Morrison, A. J.: Biopsia duodenal por aspiratión bajo control radioscópico. Pren. méd. argent.42, 2515 (1955). Zit. nach 85.

    Google Scholar 

  83. Rubin, C. E., Brandborg, L. L., Phelps, P. C., Taylor, H. C.: Studies of celiac disease. I. The apparent identical and specific nature of the duodenal and proximal jejunal lesion in celiac disease and idiopathic sprue. Gastroenterology38, 28 (1960).

    Google Scholar 

  84. —— —— Flick, A. L., Phelps, P., Parmentier, C., Niel, S. van: Studies of celiac sprue. III. The effect of repeated wheat instillation into the proximal ileum of patients on a gluten free diet. Gastroenterology43, 621 (1962).

    Google Scholar 

  85. —— Dobbins, W. O., III: Peroral biopsy of the small intestine: A review of its diagnostic usefulness. Gastroenterology49, 676 (1965).

    Google Scholar 

  86. Ruiz-Torres, A., Neuhaus, G. A., Taenzer, V.: Pathogenese und Folgen der Proteinorrhoe. Dtsch. med. Wschr.94, 1111 (1969).

    Google Scholar 

  87. Sakula, J., Shiner, M.: Coeliac disease with atrophy of the small-intestine mucosa. Lancet1957 II, 876.

    Google Scholar 

  88. Salazar de Sousa, J., Guerreiro, O., Cunha, A., Araújo, J.: Association of nephrotic syndrome with intestinal lymphangiectasia. Arch. Dis. Childh.43, 245 (1968).

    Google Scholar 

  89. Sebus, J., Fernandes, J., Bult, J. A. van der: A new twin hole capsule for peroral intestinal biopsy in children. Digestion1, 193 (1968).

    Google Scholar 

  90. Sheehy, T. W.: Intestinal biopsy. Lancet1964 I, 959.

    Google Scholar 

  91. Sheldon, W., Tempany, E.: Small intestine peroral biopsy in coeliac children. Gut7, 481 (1966).

    Google Scholar 

  92. —— Prognosis in early adult life of coeliac children treated with a gluten-free diet. Brit. med. J.1969 I, 401 (b).

    Google Scholar 

  93. Shiner, M.: Jejunal-biopsy tube. Lancet1956 I, 85.

    Google Scholar 

  94. —— Doniach, I.: Histopathologic studies in statorrhea. Gastroenterology38, 419 (1960).

    Google Scholar 

  95. Shmerling, D. H., Auricchio, S., Rubino, A., Hadorn, B., Prader, A.: Der sekundärc Mangel an intestinaler Disaccharidaseaktivität bei der Cöliakie. Quantitative Bestimmung der Enzymaktivität und klinische Beurteilung. Helv. paediat. Acta19, 507 (1964).

    Google Scholar 

  96. —— Die Saugbiopsie des Dünndarms bei Säuglingen und Kindern. Schweiz. med. Wschr.98, 295 (1968).

    Google Scholar 

  97. —— An analysis of controlled relapses in gluten-induced coeliac disease (abstr.). Acta paediat. scand,58, 311 (1969).

    Google Scholar 

  98. —— Enzymdiagnostik im Dünndarm. Schweiz. med. Wschr.99, 499 (1969).

    Google Scholar 

  99. -- Persönliche Mitteilung 1968.

  100. Shwachman, H., Khaw, K.-T., Antonowicz, I.: Peroral intestinal biopsy. Pediatrics43, 460 (1969).

    Google Scholar 

  101. Simoons, F. J.: Primary adult lactose intolerance and the milking habit: A problem in biological and cultural interrelations. I. Review of the medical research. Amer. J. dig. Dis.14, 819 (1969).

    Google Scholar 

  102. Thier, S. O., Alpers, D. H.: Disorders of intestinal transport of amino acids. Amer. J. Dis. Child.117, 13 (1969).

    Google Scholar 

  103. Townley, R. R. W., Cass, M. H., Anderson, C. M.: Small intestinal mucosal patterns of coeliac disease and idiopathic steatorrhea seen in other situations. Gut5, 51 (1964).

    Google Scholar 

  104. —— Disaccharidase deficiency in infancy and childhood. Pediatrics38, 127 (1966).

    Google Scholar 

  105. ——, Anderson, C. M.: Coeliac disease. Ergebn. inn. Med. Kinderheilk. (N.F.)26, 1 (1967).

    Google Scholar 

  106. Trier, J. S., Phelps, P. C., Eidelman, S., Rubin, C. E.: Whipple's disease: Light and electron microscopic correlation of jejunal mucosal histology with antibiotic treatment and clinical status. Gastroenterology48, 684 (1965).

    Google Scholar 

  107. Visakorpi, J. K., Immonen, P., Kuitunen, P.: Malabsorption syndrome in childhood. Acta paediat. scand.56, 1 (1967).

    Google Scholar 

  108. —— —— Intolerance to cow's milk and wheat gluten in the primary malabsorption syndrome in infancy. Acta paediat. scand.56, 49 (1967).

    Google Scholar 

  109. —— Kuitunen, P., Pelkonen, P.: Intestinal malabsorption: A clinical study of 22 children over 2 years of age. Acta paediat. scand.59, 273 (1970).

    Google Scholar 

  110. —— —— Savilahti, E.: Frequency and nature of relapses in children suffering from the malabsorption syndrome with gluten intolerance. Acta paediat. scand.59, 481 (1970).

    Google Scholar 

  111. Wagner, A., Kolb, H. P.: Katamnestische Erhebungen bei Coeliakie-Patienten. Dtsch. med. Wschr.94, 1856 (1969).

    Google Scholar 

  112. Waldmann, T. A.: Protein-losing enteropathy. Gastroenterology50, 422 (1966).

    Google Scholar 

  113. Walker-Smith, J.: Dissecting microscope appearance of small bowel mucosa in children. Arch. Dis. Childh.42, 626 (1967).

    Google Scholar 

  114. —— Small bowel morphology in childhood. Med. J. Aust.1969 I, 382.

    Google Scholar 

  115. —— Diabetes and coeliac disease. Lancet1969 II, 1366.

    Google Scholar 

  116. —— Reye, R. D. K., Soutter, G. B., Kenrick, K. G.: Small intestinal lymphangioma. Arch. Dis. Childh.44, 527 (1969).

    Google Scholar 

  117. —— Transient gluten intolerance. Arch. Dis. Childh.45, 523 (1970).

    Google Scholar 

  118. —— Disease of the small bowel in childhood. Postgrad. med. J.46, 300 (1970).

    Google Scholar 

  119. Walter, W. M., Jr., Gray, G. M.: Enzyme assay of peroral biopsies: storage conditions and basis of expression. Gastroenterology54, 56 (1968).

    Google Scholar 

  120. Weber, A., Riecken, E. O., Martini, G. A.: Über katamnestische Untersuchungen bei jugendlichen Coeliakie-Patienten. Dtsch. med. Wschr.94, 2206 (1969).

    Google Scholar 

  121. Weigel, W.: Die Duodenalbiopsie als Methode der Diagnostik und der Verlaufskontrolle bei Kindern mit Cöliakie. Mschr. Kinderheilk.117, 481 (1969).

    Google Scholar 

  122. —— Oberflächenmikroskopische Befunde an der Duodenalschleimhaut. Mschr. Kinderheilk.118, 423 (1970).

    Google Scholar 

  123. Wolff, O. H.: A-Beta-Lipoproteinaemia. Ergebn. inn. Med. Kinderheilk. (N.F.)23, 190 (1965).

    Google Scholar 

  124. Wood, I. J., Doig, R. K., Motteram, R., Hughes, A.: Gastric biopsy; report on 55 biopsies using a new flexible gastric biopsy tube. Lancet1949 I, 18.

    Google Scholar 

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Emons, D., Rotthauwe, H.W. Dünndarm-Saugbiopsie im Kindesalter: Technik, Komplikationen, Bedeutung für die Diagnose intestinaler Erkrankungen. Klin Wochenschr 49, 695–705 (1971). https://doi.org/10.1007/BF01487104

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