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Basale und Noradrenalin-(NA-)induzierte Lipolyse in isolierten Fettzellen des Menschen bei isocalorischer und hypocalorischer Diät

Basal and noradrenalin-stimulated lipolysis in isolated human fat cells under isocaloric and hypocaloric diet

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Summary

In isolated human fat cells of the subcutaneous abdominal region the effect of noradrenalin on lipolysis was tested under isocaloric and hypealoric diet. It could be demonstrated that with hypocaloric diet, the basal lipolysis increased 4,5-fold and could not be further stimulated by maximal doses of noradrenalin. It is suggested that starvation results in a maximal activity of the hormone-sensitive lipase, which it is impossible to further increase by noradrenalin.

Zusammenfassung

An isolierten Fettzellen des abdominellen Subcutanfettgewebes übergewichtiger Patienten unter isocalorischer und hypocalorischer Diät wurde die basale Lipolyse und deren Stimulierbarkeit durch Noradrenalin untersucht. Es konnte gezeigt werden, daß unter hypocalorischen Ernährungsbedingungen die basale Lipolyse auf das 4,5fache der Norm erhöht ist, und zum Unterschied von der Lipolyse unter isocalorischer Kost durch Noradrenalin nicht mehr signifikant gesteigert werden kann. Es ist anzunehmen, daß es im Hunger zu einer maximalen Aktivität der hormonsensitiven Lipase kommt, die durch maximale Dosen von Noradrenalin nicht mehr weiter stimuliert werden kann.

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Authors and Affiliations

  1. Medizinische Universitätsklinik Innsbruck, Austria

    H. -J. Lisch, P. Dittrich, S. Sailer, F. Sandhofer & H. Braunsteiner

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  1. H. -J. Lisch
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  2. P. Dittrich
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  3. S. Sailer
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  4. F. Sandhofer
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  5. H. Braunsteiner
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Lisch, H.J., Dittrich, P., Sailer, S. et al. Basale und Noradrenalin-(NA-)induzierte Lipolyse in isolierten Fettzellen des Menschen bei isocalorischer und hypocalorischer Diät. Klin Wochenschr 51, 735–737 (1973). https://doi.org/10.1007/BF01468366

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  • DOI: https://doi.org/10.1007/BF01468366

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