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Akute Virushepatitis, Australia-Antigen und Chromosomen

Acute viral hepatitis, Australia antigen and chromosomes

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Summary

1. Studies on chromosomes of lymphocyte cultures from peripheral blood were performed in 11 patients with acute viral hepatitis during the course of the disease and after normalisation of laboratory data. The relationship between the rate of structural chromosomal aberrations and the presence of Australia antigen (HAA) was investigated.

2. During the acute stage of the hepatitis, the mean aberration rate was 21,5%±6,74 (S.D.) and 7,2%±3.03 (S.D.) in the HAA positive and the HAA negative patients, respectively. The difference between the two groups was highly significant. Both groups were significantly different from a control group without liver disease in which an aberration rate of 3,2%±2,14 (S.D.) was found.

3. Rapid disappearance of HAA from serum was accompanied by a rapid decrease of the chromosomal aberration rate. In contrast, the aberration rate remained elevated in patients with HAA persistence.

4. The high aberration rates in HAA persistance might be suggestive of an increased mutagenic-cancerogenic exposure.

Zusammenfassung

1. Bei 11 Patienten mit akuter Virushepatitis wurden Chromosomenuntersuchungen an Lymphocytenkulturen des peripheren Blutes während des Krankheitsverlaufes und nach Normalisierung der Laborbefunde durchgeführt, wobei die Rate struktureller chromosomaler Aberrationen zum Australia-Antigen(HAA)-Befund und zu anderen Laborwerten in Beziehung gesetzt wurde.

2. Zum Zeitpunkt der Erstkultur während der akuten Krankheitsphase betrug die Aberrationsrate in der Patientengruppe mit HAA-positiven Hepatitiden 21,5%±6,74 (S.D.), beiden Patienten mit negativem HAA-Befund 7,2%±3.03 (S.D.); der Unterschied zwischen diesen beiden Gruppen war statistisch hoch signifikant. Beide Gruppen unterschieden sich signifikant von einer Kontrollgruppe ohne Lebererkrankung, bei der eine Aberrationsrate von 3,2%±2,14 (S.D.) gefunden wurde.

3. Bei raschem Verschwinden des HAA aus dem Serum kam es auch zu raschem Rückgang der Aberrationsrate; bei HAA-Persistenz hingegen blieb die Zahl der Aberrationen hoch.

4. Die anhaltend hohen Aberrationsraten bei HAA-Persistenz könnten Hinweis für eine erhöhte mutagen-cancerogene Belastung sein.

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Authors and Affiliations

  1. II. Medizinische Universitätsklinik Wien, Austria

    Walter Vormittag & Gustav Paumgartner

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  1. Walter Vormittag
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  2. Gustav Paumgartner
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Herrn Prof. Dr. G. Grabner (II. Medizinische Universitätsklinik Wien, Vorstand: Prof. Dr. K. Fellinger) haben wir für zahlreiche, wertvolle Ratschläge zu danken.

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Vormittag, W., Paumgartner, G. Akute Virushepatitis, Australia-Antigen und Chromosomen. Klin Wochenschr 51, 445–449 (1973). https://doi.org/10.1007/BF01467749

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