Summary
Seven of eight patients with pheochromocytoma showed elevated plasma renin activity (>3 ng/ml/3 hr). Four of these seven patients simultaneously had abnormally high plasma aldosterone (>120 pg/ml). It was found by selective determinations of plasma renin activity in both renal veins that two different mechanisms may be responsible for the observed hyperreninism. Firstly, the pheochromocytoma can lead mechanically to a reduction in renal blood flow inducing an increased renin secretion. Secondly, catecholamines are known to stimulate renin secretion. Two of the eight patients with pheochromocytoma showed an increased cortisol secretion.
Zusammenfassung
Sieben von 8 Patienten mit einem Phäochromocytom zeigten eine über die Norm erhöhte Plasma-Renin-Aktivität (>3 ng/ml/3 h). Bei 4 der 7 Patienten mit Hyperreninismus konnte gleichzeitig auch ein abnorm hohes Plasma-Aldosteron nachgewiesen werden (>120 pg/ml). Seitengetrennte Bestimmungen der Plasma-Renin-Aktivität im Nierenvenenblut zweier Patienten zeigten, daß als Ursachen des Hyperreninismus sowohl eine Verringerung der Nierendurchblutung durch Tumorkompression im Sinne eines Goldblattmechanismus als auch eine Stimulation der renalen Reninsekretion durch Katecholamine in Frage kommen können. Bei 2 unserer Patienten mit einem Phäochromocytom fand sich eine über die Norm gesteigerte Cortisolsekretion.
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Vetter, H., Fischer, N., Bayer, J.M. et al. Aldosteron, Cortisol und Plasma-Renin-Aktivität beim Phäochromocytom. Klin Wochenschr 52, 719–721 (1974). https://doi.org/10.1007/BF01469334
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DOI: https://doi.org/10.1007/BF01469334