Skip to main content
Log in

Granulocytendysfunktion

Granulocyte dysfunction. Part II. Secondary defects

II. Erworbene Störungen

  • Übersichten
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

In the first part we reviewed both the molecular basis of granulocyte function and the inborn defects. The present chapter summarizes our knowledge of the secondary defects of chemotaxis, opsonisation, phagocytosis and intracellular microbicidal activity.

Zusammenfassung

Im ersten Teil dieser Übersicht haben wir einen Überblick über die molekulare Basis der Granulocytenfunktion und deren wesentlichsten angeborenen Störungen gegeben. Der vorliegende zweite Teil soll das gegenwärtige Wissen über die sekundären Störungen der Chemotaxis, Opsonierung, Phagocytose und intracellulären Keimabtötung zusammenfassen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literatur

  1. Alper, C.A., Abramson, N., Johnston, R.B., Jandl, J.H., Rosen, F.S.: Increased susceptibility to infection associated with abnormalities of complement mediated function of the third component of complement (C3). N. Engl. J. Med.282, 349 (1970)

    Google Scholar 

  2. Alper, C.A., Colten, H.R., Rosen, F.S.: Homozygous deficiency of C3 in a patient with repeated infections. Lancet 1179 (1972)

  3. Arkawa, T., Wada, Y., Hayashi, T., Kakizaki, R., Chiba, R., Konno, T.: Uracil-uric refractory anemia with peroxydase negative neutrophils. Tokoku J. Exp. Med.87, 52 (1965)

    Google Scholar 

  4. Azimi, P.H., Bodenbender, J.G., Hintz, R.L., Kontras, S.B.: Chronic granulomatous disease in three female siblings. J.A.M.A.206, 2865 (1968)

    Google Scholar 

  5. Baehner, R.L.: Use of the nitro blue tetrazolium test in clinical pediatrics. Am. J. Dis. Child.128, 449 (1974)

    Google Scholar 

  6. Baehner, R.L.: Molecular basis for functional disorders of phagocytes. J. Pediatrics84, 317 (1974)

    Google Scholar 

  7. Baehner, R.L., Nathan, D.G.: Leukocyte oxydase: Defective activity in chronic granulomatous disease. Science155, 835 (1967)

    Google Scholar 

  8. Baehner, R.L., Karnovsky, M.L.: Deficiency of reduced nicotinamide adenine dinucleotide oxidase in chronic granulomatous disease. Science162, 1277 (1968)

    Google Scholar 

  9. Baehner, R.L., Nathan, D.G.: Quantitative nitroblue tetrazolium test in chronic granulomatous disease. New Engl. J. Med.278, 972 (1968)

    Google Scholar 

  10. Baehner, R.L., Johnston, R.B., Nathan, D.G.: Comparative study of the metabolic and bactericidal characteristics of severely glucose-6-phosphat-dehydrogenase-deficient polymorphonuclear leukocytes and leukocytes from children with chronic granulomatous disease. J. of Reticuloendothelial Society12, 150 (1972)

    Google Scholar 

  11. Baehner, R.L., Neiburger, R.G., Johnson, D.E., Murrmann, S.M.: Transient bactericidal defect of peripheral blood phagocytes from children with acute lymphoblastic leukemia receiving craniospinal irradiation. The New Engl. J. of Med.289, 1209 (1973)

    Google Scholar 

  12. Bagdale, J.D., Nielson, K., Root, R., Bulger, R.: Host defence in diabetes mellitus: The feckless phagocyte during poor control and ketoacidosis. Diabetes19, 364 (1970) (Abstr.)

    Google Scholar 

  13. Baggiolini, M., Bretz, U., Gusus, B.: Biochemical characterization of azurophil and specific granules from human and rabbit polymorphonuclear leukocytes. Schweiz. med. Wschr.104, 129 (1974)

    Google Scholar 

  14. Bainton, D.F.: Origin, content and fate of PMN granules. In: R.C. Williams and H.H. Fudenberg (Ed.) Phagocytic mechanisms in Health and Disease, Thieme Stuttgart 123 (1972)

  15. Bainton, D.F., Farquhar, M.G.: Differences in encyme content of azurophil and specific granules of polymorphnuclear leukocytes. J. Cell Biol.39, 286 (1968)

    Google Scholar 

  16. Bannatyne, R.M., Showron, P.N., Weber, J.L.: Job's syndrome — a variant of chronic granulomatous disease. J. Pediat.75, 236 (1969)

    Google Scholar 

  17. Becker, E.L., Ward, P.A.: Partial biochemical characterization of the activated esterase required in the complement dependant chemotaxis of rabbit leukocytes. J. Exp. Med.125, 1021 (1967)

    Google Scholar 

  18. Bellanti, J.A., Cantz, B.E., Schlegel, R.J.: Accelerated decay of glucose-6-phosphate-dehydrogenase activity in chronic granulomatous disease. Pediat. Res.4, 405 (1970)

    Google Scholar 

  19. Berendes, H., Bridges, R.A., Good, R.A.: A fatal granulomatosis of childhood. Minn. Med.40, 309 (1957)

    Google Scholar 

  20. Blume, R.S., Bennett, J.M., Yankee, R.A., Wolff, S.M.: Defective granulocyte regulation in the Chediak-Higashi syndrome. N. Engl. J. Med.279, 1009 (1968)

    Google Scholar 

  21. Blume, R.S., Padgett, G.A., Wolff, S.M., Bennett, J.M.: Giant neutrophil granules in the Chediak-Higashi syndrome of man, mink, cattle and mice. Can. J. Comp. Med.33, 271 (1969)

    Google Scholar 

  22. Bodey, G.P.: Fungal infection complicating acute leukemia. J. Chron. Disease19, 667 (1966)

    Google Scholar 

  23. Boggs, D.R.: The cellular composition of inflammatory exudates in human leukemics. Blood15, 466 (1960)

    Google Scholar 

  24. Boyden, S.: The chemotactic effect of mixture of antibody and antigen on polymorphnuclear leukocytes. J. Exp. Med.115, 453 (1962)

    Google Scholar 

  25. Brand, L., Hedberg, H.: Impaired phagocytosis by peripheral blood granulocytes in systemic lupus erythematodes. Scand. J. Haematol6, 348 (1969)

    Google Scholar 

  26. Bretz, U., Baggiolini, M.: Biochemical and morphological characterization of azurophil and specific granules of human neutrophilic-polymorphnuclear leukocytes. J. Cell. Biol.63, 251 (1974)

    Google Scholar 

  27. Bridges, R.A., Berendes, H., Good, R.A.: A fatal granulomatous disease of childhood. The clinical, pathological and laboratory features of a new syndrome. Amer. J. Dis. Child97, 387 (1959)

    Google Scholar 

  28. Brogan, T.D.: Phagocytosis by polymorphnuclear leukocytes from patients with renal failure. Brit. Med. J.3, 596 (1967)

    Google Scholar 

  29. Bybee, J.D., Rogers, D.F.: The phagocytic activity of polymorphnuclear leukocytes obtained from patients with diabetes mellitus. J. Lab. Clin. Med.64, 1 (1964)

    Google Scholar 

  30. Chandra, R.K., Seth, V.: Reduced bactericidal capacity of polymorphnuclear leucocytes in nephrotic syndrome and effect of steroid therapy. Experientia28, 1354 (1972)

    Google Scholar 

  31. Chang, C., Houck, J.C.: Demonstration of the chemotactic properties of collagen. Proc. Soc. Exp. Biol. Med.134, 22 (1970)

    Google Scholar 

  32. De Chatelet, L.R., Cooper, M.R., Mc Call, C.E.: Dissociation by colchicine of the hexose monophosphat shunt activation from the bactericidal activity of leukocyte. Infect. Immun.3, 66 (1971)

    Google Scholar 

  33. Chediak, M.: Nouvelle anomalie leucocytaire de caractère constitutionel et familial. Rév. Hemat.7, 362 (1952)

    Google Scholar 

  34. Clark, R.A., Kimball, H.R.: Defective granulocyte chemotaxis in the Chediak-Higashi syndrome. J. Clin. Invest.50, 2645 (1971)

    Google Scholar 

  35. Clark, R.A., Root, R.K., Kimball, H.R.: Defective neutrophil chemotaxis in a child with recurrent infections. Clin. Res.19, 455 (1971)

    Google Scholar 

  36. Clark, R.A., Kimball, H.R., Decker, J.L.: Neutrophil chemotaxis in systemic lupus erythematosus. Ann. rheum. Dis.33, 167 (1974)

    Google Scholar 

  37. Cocchi, P., Mori, S., Becattini, A.: NBT-test in premature infants. Lancet II, 1426 (1969)

    Google Scholar 

  38. Constantopoulos, A., Najjar, V.A., Smith, J.W.: Tuftsin deficiency. A new syndrome with defective phagocytosis. J. Pediat.80, 564 (1972)

    Google Scholar 

  39. Constantopoulos, A., Najjar, V.A.: Tuftsin deficiency syndrome. Acta Paed. Scand.62, 645 (1973)

    Google Scholar 

  40. Constantopoulos, A., Najjar, V.A.: The requirement for membrane sialic acid in the stimulation of phagocytosis by the natural tetrapeptide, tuftsin. J. Biol. Chem.248, 3819 (1973)

    Google Scholar 

  41. Constantopoulos, A., Najjar, V.A., Wish, J.B., Necheles, T.H., Stolbach, L.L.: Defective phagocytosis due to tuftsin deficiency in splenectomized subjects. Amer. J. of Dis. of Children125, 663 (1973)

    Google Scholar 

  42. Cooper, M.R., De Chatelet, L.R., McCall, C.E., Lavia, M.F., Spurr, C.L., Baehner, R.L.: Leukocyte G-6-PD deficiency. LancetII, 110 (1970)

    Google Scholar 

  43. Craddock, P.R., Yawata, Y., Van Santen, L., Gilberstadt, S., Silvis, S., Jacob, H.S.: Acquired phagocyte dysfunction. A complication of hypophosphatemia of parenteral hyperalimentation. New Engl. J. Med.290, 1403 (1974)

    Google Scholar 

  44. Crepea, S.B., Magnin, G.E., Seastone, C.V.: Effect of ACTH and cortisone on phagocytosis. Proc. Soc. Exp. Biol. Med.77, 704 (1961)

    Google Scholar 

  45. Curnutte, J.T., Whitten, D.M., Babior, B.M.: Defective superoxide production by granulocytes from patients with chronic granulomatous disease. New Engl. J. Med.290, 593 (1974)

    Google Scholar 

  46. Davis, S.D., Schaller, J., Wedywood, R.J.: Job's syndrome. Recurrent “cold” staphylococcal abscesses. LancetI, 1031 (1966)

    Google Scholar 

  47. Davis, W.C., Douglas, S.D., Fudenberg, H.H.: A selective neutrophil dysfunction syndrome: Impaired killing of staphylococci. Ann. Int. Med.69, 1237 (1968)

    Google Scholar 

  48. Deut, P.B., Fish, L.A., White, J.G., Good, R.A.: Chediak-Higashi syndrome: Observation on the nature of the associated malignancy. Lab. Invest.15, 1634 (1966)

    Google Scholar 

  49. Dosset, J.H., Williams, R.C., Quie, P.G.: Studies on interaction of bacteria, serum factors and polymorphnuclear leukocytes in mothers and newborns. Pediatrics44, 49 (1969)

    Google Scholar 

  50. Douglas, S.D., Davis, W.C., Fudenberg, H.H.: Granulocytopathies. Pleomorphism of neutrophil dysfunction. Am. J. Med.46, 901 (1969)

    Google Scholar 

  51. Douglas, S.D., Schopfer, K.: Phagocyte function in proteincalorie malnutrition. Clin. Exp. Immunol.17, 121 (1974)

    Google Scholar 

  52. Drachman, R.H., Root, R.K., Wood, W.B.: Studies on the effect of experimental nonketotic diabetes mellitus on antibacterial defence. I. Demonstration of a defect in phagocytosis. J. Exp. Med.124, 227 (1966)

    Google Scholar 

  53. Dunn, W.B., Hardin, J.H., Spicer, S.S.: Ultrastructural localization of myeloperoxydase in human neutrophil and rabbit heterophil and eosinophil leukocytes. Blood32, 935 (1968)

    Google Scholar 

  54. Edelson, P.J., Stites, D.P., Gold, S., Fudenberg, H.H.: disorders of neutrophil function. Defects in the early stages of the phagocytic process. Clin. Exp. Immunol.13, 21 (1973)

    Google Scholar 

  55. Erikson, W.D., Burgert, E.O., Lynn, H.B.: The hazard of infection following splenectomy in children. Am. J. Dis. Child116, 1 (1968)

    Google Scholar 

  56. Farhadian, H.: The use of the NBT test in rheumatic diseases of childhood. Proc. Inst. Med. Chicago28, 471 (1971)

    Google Scholar 

  57. Feigin, R.D., Shackelford, P.S., Choi, S.C., Flake, K.K., Franklin, F.A., Eisenberg, C.S.: Nitroblue tetrazolium dye test as an aid in the differential diagnosis of febrile disorders. J. Pediatrics78, 230 (1971)

    Google Scholar 

  58. Fidalgo, B.V., Najjar, V.A.: The physiological role of the lymphoid system III. Leucophilic γ-globulin and the phagocytic activity of the polymorphnuclear leucocytes. Proc. Nat. Acad. Sci.57, 957 (1967)

    Google Scholar 

  59. Fidalgo, B.V., Najjar, V.A.: The physiologic role of the lymphoid system IV. The stimulatory effect of leucophilic γ-globulin (leukokinin) on the phagocytic activity of human polymorphnuclear leucocyte. Biochem.6, 3386 (1967)

    Google Scholar 

  60. Fleyer, R.H., Finch, S.C.: The effects of prostaglandin E1 on human granulocyte metabolism during phagocytosis. J. of Reticuloendothelial Soc.14, 325 (1973)

    Google Scholar 

  61. Ford, D.K., Price, G.E., Culling, C.F.A., Vassar, P.S.: Familial lipochrome pigmentation of histiocytes with hyperglobulinemia, pulmonary infiltration, splenomegaly, arthritis and susceptibility to infection. Amer. J. of Med.33, 478 (1962)

    Google Scholar 

  62. Fridovich, J.: Superoxide radical and the bactericidal action of phagocytosis. New Engl. J. Med.290, 624 (1974)

    Google Scholar 

  63. Gallis, S.S.: Splenectomy in childhood and the hazard of overwhelming infection. In Gellis (ed.) Yearbook of Pediatrics, Chicago, Yearbook Med. Publishers 84 (1971)

    Google Scholar 

  64. Garvin, J.E.: Factors affecting the adhesiveness of human leukocytes and plateles in vitro. J. Exp. Med.114, 51 (1961)

    Google Scholar 

  65. Goel, K.M., Vowels, M.R.: Leukocyte function in normal and pre-term infants. Acta Paediat. Scand.63, 122 (1974)

    Google Scholar 

  66. Goetzl, E.J., Gigli, I., Wasserman, W.S., Austen, K.F.: A neutrophil immobilizing factor derived from human leukocytes. II. Specificity of action on polymorphnuclear leukocytes mobility. J. Immunol.111, 938 (1973)

    Google Scholar 

  67. Gold, S.B., Hanes, D.M., Stites, D.P., Fudenberg, H.H.: Abnormal kinetics of degranulation in chronic granulomatous disease. New Engl. J. of Med.291, 332 (1974)

    Google Scholar 

  68. Goldman, J.M., Catovsky, D.: The function of the phagocytic leukocytes in leukemia. Brit. J. of Haemat.23, 223 (1972)

    Google Scholar 

  69. Goldman, J.M., Th'ng, K.H.: Phagocytic function of leukocytes from patients with acute myeloid and chronic granulocytic leukaemia. Brit. J. of Haemat.25, 299 (1973)

    Google Scholar 

  70. Good, R.A., Quie, P.G., Windhorst, D.P., Page, A.R., Rodey, G.E., White, J., Wolfson, J.J., Holmes, B.H.: Fatal (chronic) granulomatous disease of childhood: A hereditary defect of leukocyte function. Sem. Hemat.5, 215 (1968)

    Google Scholar 

  71. Graham, G.S.: The neutrophilic granules of the circulating blood in health and in disease. A preliminary report. N.Y. State J. Med.20, 46 (1970)

    Google Scholar 

  72. Gray, G.R., Stamatoyannopoulos, G., Naiman, S.C., Kliman, M.R., Klebanoff, S.J., Austin, T., Yoshida, A., Robinson, G.C.F.: Neutrophil dysfunction. Chronic granulomatous disease, and non-spherocytic haemolytic anaemia caused by complete deficiency of glucose-6-phosphate dehydrogenase. LancetII, 530 (1973)

    Google Scholar 

  73. Gregory, L., Williams, R., Thompson, E.: Leukocyte function in down's syndrome and acute leukaemia. LancetII, 1359 (1972)

    Google Scholar 

  74. Grignaschi, V.J., Sperperato, A.M., Etcheverry, M.J., Macario, A.J.L.: Un nicevo cuadro citoquimico: negatividad espontanea de las reacciones de peroxidases, oxidases y lipido en la propenie neutrofilia y en los monocitos de dos hermanos. Rev. Asoc. Med. Argent.77, 218 (1963)

    Google Scholar 

  75. Haferkamp, O.: Morphologische Aspekte der Immunantwort. Verh. d. Deutsch. Ges. f. Inn. Med.78, 733 (1972)

    Google Scholar 

  76. Haferkamp, O.: Einführung in die Immunologie der Infektabwehr. Med. Welt23, 543 (1972)

    Google Scholar 

  77. Haferkamp, O.: Der schutzlose Organismus. Dtsch. med. Wschr.99, 203 (1974)

    Google Scholar 

  78. Haferkamp, O., Bültmann, B., Kleeberg, U.R., Haas, R.J., Borowski, K., Wildfeuer, A., Schachenmayr, W., Heymer, B., Niethammer, D., Kleihauer, E.: Serumabhängige Funktionsstörungen von Granulozyten. Dtsch. med. Wschr.99, 182 (1974)

    Google Scholar 

  79. Harris, H.: Chemotaxis of granulocytes. J. Pathol. Bacteriol.66, 135 (1953)

    Google Scholar 

  80. Higashi, O.: Congenital abnormality of peroxidase granules. A case of congenital gigantismus of peroxidase granules. Tohuku. J. Exp. Med.58, 246 (1953)

    Google Scholar 

  81. Higashi, O., Katsayama, N., Satodate, R.: A case with hematological abnormality characterized by the absence of peroxydase activity in blood polymorphnuclear leukocytes. Tohuku. J. Exp. Med.87, 77 (1965)

    Google Scholar 

  82. Higgins, G.R., Swanson, V., Yamazaki, J.: Granulocytasthenia: A unique leukocyte dysfunction associated with decreased resistance to infection. Clin. Res.18, 209 (1970) (Abstr.).

    Google Scholar 

  83. Hill, H.R., Quie, P.G.: Raised serum-IgE levels and defectives neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. LancetI, 183 (1974)

    Google Scholar 

  84. Hill, H.R., Quie, P.G., Pabst, H.F., Ochs, H.D., Clark, R.A., Klebanoff, S.J., Wedgwood, R.J.: Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent “cold” staphylococcal abscesses. LancetII, 617 (1974)

    Google Scholar 

  85. Hirsch, J.G., Church, A.B.: Adrenal steroid and infection: Effect of cortisone administration on polymorphnuclear leukocyte function and on serum opsonins and bactericidins. J. Clin. Invest.40, 794 (1961)

    Google Scholar 

  86. Hirsch, J.G., Strauss, B.: Studies in heat-labile opsonin in rabbit serum. J. Immunol.92, 145 (1964)

    Google Scholar 

  87. Hitzig, W.H.: Gesunde und kranke Phagocytose. Theorie, Klinik und Laboratoriumsdiagnose. Triangel12, 57 (1973)

    Google Scholar 

  88. Hitzig, W.H., Molz, G., Plüss, H.J., Renner, R.: Progressive septische Granulomatose. Helv. Paediat. Acta24, 246 (1969)

    Google Scholar 

  89. Holland, J.F., Senn, H., Banerjee, R.: Quantitative studies of localized leukocyte mobilization in acute leukemia. Blood37, 499 (1971)

    Google Scholar 

  90. Holmes, B., Quie, P.G., Windhorst, D.B., Good, R.A.: Fetal granulomatous disease of childhood. An inborn abnormality of phagocytic function. LancetI, 1225 (1966)

    Google Scholar 

  91. Holmes, B., Page, A.R., Good, R.A.: Studies of the metabolic activity of leukocytes from patients with genetic abnormality of phagocytic function. J. Clin. Invest.46, 1422 (1967)

    Google Scholar 

  92. Holmes, B., Day, N., Haseman, J., Good, R.A.: The development of bactericidal capacity and phagocytosis-associated metabolism of fetal pig leukocytes. Zitiert nach: Metabolic and Functional Abnormalities of Human Neutrophils. In Phagocytic Mechanisms in Health and Disease. Ed: R.C. Williams Jr., H.H. Fudenberg, Thieme 51 (1972)

  93. Humbert, J.R., Kurtz, M.L., Hathaway, W.E.: Increased reduction of nitroblue tetrazolium by neutrophils of newborn infants. Pediatrics45, 125 (1970)

    Google Scholar 

  94. Jacobs, J.C., Miller, M.E.: Fetal familial leiners disease: A deficiency of the opsonic activity of serum complement. Pediatrics49, 225 (1972)

    Google Scholar 

  95. Johnston, R.B., Klemperer, M.R., Alper, C.A., Rosen, F.S.: The enhancement of bacterial phagocytosis by serum. The role of complement components and two cofactors. J. Exp. Med.129, 1275 (1969)

    Google Scholar 

  96. Johnston, R.B., Baehner, R.L.: Chronic granulomatous disease: Correlation between pathogenesis and clinical findings. Pediatrics48, 730 (1971)

    Google Scholar 

  97. Jungi, W.F., Rhomberg, W.U., Peters, W., Senn, H.J.: Beeinflussung der Granulozytenfunktion durch Corticosteroide. Therapeutische Konsequenzen. Schweiz. Med. Wschr.101, 1790 (1971)

    Google Scholar 

  98. Karnovsky, M.L.: Metabolic basis of phagocytic activity. Physiol. Rev.42, 143 (1962)

    Google Scholar 

  99. Karnovsky, M.L., Simmons, S., Karnovsky, M.J., Nowesworthy, J., Glass, E.A.: Comparative studies on the metabolic basis of bactericidal activity in leukocytes. In: R.C. Williams and H.H. Fudenberg (Ed.) Phagocytic mechanisms in Health and Disease. Thieme Stuttgart 67 (1972)

  100. Kevy, S.V., Tefft, M., Vawter, G.F., Rosen, F.S.: Hereditary splenic hypoplasia. Pediatrics42, 752 (1968)

    Google Scholar 

  101. Kimball, H., Ford, G.: Granulocyte lysosomal enzymes in the Chediak-Higashi syndrome (CHS). Clin. Res.18, 407 (1970)

    Google Scholar 

  102. Klebanoff, S.J.: A peroxidase-mediated antimicrobial system in leukocytes. J. Clin. Invest.46, 1078 (1967)

    Google Scholar 

  103. Klebanoff, S.J.: Myeloperoxydase-halide-hydrogen peroxid antibactericidal system. J. Bact.95, 2131 (1968)

    Google Scholar 

  104. Klebanoff, S.J.: Myeloperoxydase-mediated antimicrobial systems and their role in leukocyte function. In: Schultz, J. (Ed.) Biochemistry of the phagocytic process: Localization and the role of myeloperoxidase and the mechanism of the halogenation reaction, North Holland, Amsterdam 89 (1970)

  105. Klebanoff, S.J.: The myeloperoxydase-mediated antimierobial systems. In: R.C. Williams and H.H. Fudenberg (Ed.) Phagocytic mechanisms in Health and Disease, Thieme Stuttgart 3 (1972)

  106. Koch, Ch.: Neutrophil granulocyte function in vitro. Acta path. microbiol. scand. Section82, 127 (1974)

    Google Scholar 

  107. Kontras, S.B., Bass, J.C.: Chronic granulomatous disease. LancetII, 646 (1969)

    Google Scholar 

  108. Landing, B.H., Shirkey, H.S.: A syndrome of recurrent infection and infiltration of viscera by pigmented lipid histiocytosis. Pediatrics20, 431 (1957)

    Google Scholar 

  109. Lehrer, R.J.: Measurement of candidacidal activity of specific leukocyte types in mixed cell population: I. Normal, myeloper-oxidase-deficient, and chronic granulomatous disease neutrophils. Infect. Immun.2, 42 (1970)

    Google Scholar 

  110. Lehrer, R.J.: Inhibition by sulfonamides of the candidacidal activity of human leukocytes. J. Clin. Invest.50, 2498 (1971)

    Google Scholar 

  111. Lehrer, R.J.: The fungicidal activity of human leukocytes. In: R.C. Williams and H.H. Fudenberg (Ed.) Phagocytic mechanisms in Health and Disease. Thieme Stuttgart 151 (1972)

    Google Scholar 

  112. Lehrer, R.J., Cline, M.J.: Leukocyte myeloperoxydase deficiency and disseminated candidadiasis. The role of myeloperoxydase in resistance to candida infection. J. clin. Invest.48, 1478 (1969)

    Google Scholar 

  113. Lehrer, R.J., Cline, M.J.: Interaction of candida albicans with human leukocytes and serum. J. Bact.98, 996 (1969)

    Google Scholar 

  114. Lehrer, R.J., Cline, M.J.: Leukocyte candidacidal activity and resistance to systemic candidiasis in patients with cancer. Cancer27, 1211 (1971)

    Google Scholar 

  115. Lehrer, R.J., Goldberg, L.S., Apple, M.A., Rosenthal, N.P.: Refractory megaloblastic anemia with myeloperoxidase-deficient leukocytes. Ann. Intern. Med.76, 447 (1972)

    Google Scholar 

  116. Malawista, S.E., Bodel, P.: The dissociation by colchicine of phagocytosis from increased oxygen consumption in human leukocytes. J. clin. Invest.46, 786 (1967)

    Google Scholar 

  117. Mandell, G.L., Rubin, W., Hook, E.W.: The effect of an NADH-oxidase-inhibitor (hydrocortisone) on polymorphnuclear leukocyte bactericidal activity. J. clin. Invest.49, 1381 (1970)

    Google Scholar 

  118. Marks, M.I., Dery, P.: Diagnostic usefulness of the nitroblue tetrazolium dye reduction test in a children's hospital. Acta Pediat. Scand.63, 427 (1974)

    Google Scholar 

  119. McCall, C.E., Caves, J., Cooper, R., De Chatelet, L.: Functional characteristics of human toxic neutrophils. J. Infect. Diseases124, 68 (1971)

    Google Scholar 

  120. McRipley, R.J., Selvaray, R.J., Glovsky, M.M.: The role of the phagocyte in host-parasite interactions. VI. The phagocytic and bactericidal capabilities of leukocytes from patients under-going x-irradiation. Radiat. Res.31, 706 (1967)

    Google Scholar 

  121. Metschnikoff, E.: Untersuchungen über die mesodermalen Phagocyten einiger Wirbeltiere. Biol. Zentr.3, 560 (1883)

    Google Scholar 

  122. Miller, M.E.: Deficiency of chemotactic function in the human neonate: A previously unreognized defect of the inflammatory response. Pediat. Res.3, 497 (1969)

    Google Scholar 

  123. Miller, M.E.: Chemotactic function in the human neonate: humoral and cellular aspects. Pediat. Res.5, 487 (1971)

    Google Scholar 

  124. Miller, M.E., Nilsson, V.R.: A familial deficiency of the phagocytosis enhancing activity of serum related to a dysfunction of the fifth component of the complement (C5). N. Engl. J. Med.282, 354 (1970)

    Google Scholar 

  125. Miller, D.R., Kaplan, H.G.: Decreased nitroblue tetrazolium dye reduction in the phagocytes of patients receiving prednisone. Pediatrics45, 861 (1970)

    Google Scholar 

  126. Miller, M.E., Osoki, F.A., Harris, M.B.: Lazy-leukocyte syndrome. A new disorder of neutrophil function. Lancet1, 665 (1971)

    Google Scholar 

  127. Miller, M.E., Baker, L.: Leukocyte functions in juvenile diabetes mellitus: Humoral and cellular aspects. J. of Pediat.81, 979 (1972)

    Google Scholar 

  128. Miller, M.E., Norman, M.E., Koblenzer, P.J., Schonauer, T.: A new familiar defect of neutrophil movement. J. of Lab. and Clin. Med.82, 1 (1973)

    Google Scholar 

  129. Montgomery, J.Z., Kalmanson, G.M., Guze, L.B.: Leukocyte phagocytosis and serum bactericidal activity in chronic renal failure. The Amer. J. of the Med. Sci.246, 385 (1972)

    Google Scholar 

  130. Mowat, A.G., Baum, J.: Chemotaxis of polymorphnuclear leukocytes from patients with diabetes mellitus. N. Engl. J. Med.284, 621 (1971)

    Google Scholar 

  131. Mowat, A.G., Baum, J.: Chemotaxis of polymorphnuclear leukocytes from patients with rheumatoid arthritis. J. Clin. Invest.50, 2541 (1972)

    Google Scholar 

  132. Najjar, V.A., Fidalgo, B.V., Stitt, E.: The physiological role of the lymphoid system VII. The disappearance of leukokinin activity following splenectomy. Biochem.7, 2376 (1968)

    Google Scholar 

  133. Najjar, V.A., Nishioka, N.: Tuftsin: A natural phagocytosis stimulating peptide. Nature228, 672 (1970)

    Google Scholar 

  134. Najjar, V.A., Constantopoulos, A.: A new phagocytosis stimulating tetrapeptide hormone, tuftsin, and its role in disease. Res. J. Ret. Soc.12, 197 (1972)

    Google Scholar 

  135. Nathan, D.G., Baehner, R.L., Weaver, D.K.: Failure of nitro blue tetrazolium reduction in the phagocytic vakuoles of leukocytes in chronic granulomatous disease. J. Clin. Invest.48, 1895 (1969)

    Google Scholar 

  136. Niethammer, D., Kleihauer, E.: Nitroblautetrazolium-Test und Index. DMW41, 2071 (1974)

    Google Scholar 

  137. Niethammer, D., Dieterle, U., Kleihauer, E., Wildfeuer, A., Haferkamp, O., Hitzig, W.H.: An inherited defect in granulocyte function: Impaired chemotaxis, phagocytosis and intracellular hilling of candida albicans. In Vorbereitung

  138. Nishioka, K., Constantopoulos, A., Satoh, P.S.: The characteristics, isolation, structure and synthesis of the phagocytosis stimulating peptide tuftsin. B.B.R.C.47, 172 (1972)

    Google Scholar 

  139. Norman, M.E., Miller, M.E.: Spontaneous chemotaxis in patients with glomerulonephritis and the nephrotic syndrome. J. of Pediat.83, 390 (1973)

    Google Scholar 

  140. Norman, M.E., Miller, M.E.: Spontaneous chemotaxis in acute glomerulonephritis: Demonstration of a positive correlation with disease activity. J. of Pediat.85, 20 (1974)

    Google Scholar 

  141. Orozco, J.H., Jasin, H.E., Ziff, M.: Defective phagocytosis with systemic lupus erythematodes. Arthritis Rheum.13, 342 (1970)

    Google Scholar 

  142. Pachman, L.M., Jayanetra, P., Rothberg, R.M.: Rheumatoid sera and soluble complexes: Nitroblue tetrazolium dye test and hexose monophosphate shunt activation. Pediatrics52, 823 (1973)

    Google Scholar 

  143. Page, A.R., Berendes, H., Warner, J., Good, R.A.: The Chediak-Higashi syndrome. Blood20, 330 (1962)

    Google Scholar 

  144. Park, B.H., Holmes, B.M., Rodey, G.E., Good, R.A.: Nitroblue tetrazolium test in children with fatal granulomatous disease and newborn infants. LancetI, 157 (1969)

    Google Scholar 

  145. Park, B.H.: The use and limitations of the nitroblue tetrazolium test as a diagnostic aid. J. Pediat.78, 376 (1971)

    Google Scholar 

  146. Park, B.H., Fikring, S.M., Smithwick, E.M.: Infection and nitroblue tetrazolium by neutrophils: LancetII, 532 (1968)

    Google Scholar 

  147. Paul, B.B., Strauss, R., Sbarra, J.: The role of the phagocyte in host-parasite interactioning XVI. Effect of irradiation on H2O2-production in guinea pig exudate cells. J. Reticuloendothel. Soc.5, 538 (1968)

    Google Scholar 

  148. Paul, B.B., Strauss, R.R., Jacobs, A.A., Sbarra, A.J.: Function of H2O2 myeloperoxydase and hexose monophosphate shunt encymes in phagocytizing cells from different species. Infect. Immun.1, 338 (1970)

    Google Scholar 

  149. Perillie, P.E., Finch, S.C.: Quantitative studies of the local exudation cellular reaction in acute leukemia. J. Clin. Invest.43, 425 (1964)

    Google Scholar 

  150. Pilgrim, U., Gindrat, J.J., Ruckli, B., Hitzig, W.H.: Nitroblau-Tetrazolium (NBT)-Reduktion in Granulozyten von Kindern mit akuter Leukämie. Schw. Med. Wschr.104, 147 (1974)

    Google Scholar 

  151. Pillemen, L.L., Blum, L., Lepow, I.H.: The properdin system and immunity I. Demonstration and isolation of a new serum protein, properdin, and its role in immune phenomena. Science120, 279 (1954)

    Google Scholar 

  152. Preisig, E., Hitzig, W.H.: Nitroblue-tetrazolium test for the detection of chronic granulomatous disease-technical modification. Europ. J. clin. Invest.1, 409 (1971)

    Google Scholar 

  153. Qualliotine, D., De Chatelet, L.R., McCall, C.E., Cooper, M.R.: Stimulation of oxidative metabolism in polymorphnuclear leukocytes by catecholamines. J. Reticuloendothel. Soc.11, 263 (1972)

    Google Scholar 

  154. Quie, P.G., White, J.G., Holmes, B., Good, R.A.: In vitro bactericidal capacity of human polymorphnuclear leukocytes: Diminished activity in chronic granulomatous disease of childhood. J. clin. Invest.46, 668 (1967)

    Google Scholar 

  155. Quie, P.G., Kaplan, E.L., Page, A.R., Grushay, F.L., Malawista, S.E.: Defective polymorphnuclear leukocyte function and chronic granulomatous disease in two female children. New Engl. J. Med.278, 976 (1968)

    Google Scholar 

  156. Rabinowitch, M.: Phagocytosis. The engulfment stage. Sem. Hemat.5, 134 (1968)

    Google Scholar 

  157. Rebuck, J.W., Crowley, J.H.: Part II. Techniques in the study of leukocytic functions. A method of studying leukocytic functions in vivo. Ann. N.Y. Acad. Sci.59, 757 (1955)

    Google Scholar 

  158. Rodey, G.E., Park, B.H., Ford, D.K., Gray, B.H., Good, R.A.: Defective bactericidal activity of peripheral blood leukocytes in lipochrome histiocytosis. Am. J. of Med.49, 322 (1970)

    Google Scholar 

  159. Rohmann, H.: Über die Phagocytose des Leukocyten bei Diabetikern. Folia haemat. Lpz.85, 267 (1966)

    Google Scholar 

  160. Root, R.K.: Defective bactericidal functions of Chediak-Higashi syndrome (CHS) leukocytes. Clin. Res.19, 466 (1971)

    Google Scholar 

  161. Root, R.K., Blume, R.S., Wolff, S.M.: Abnormal leukocyte function in the Chediak-Higashi syndrome. Clin. Res.16, 335 (1968)

    Google Scholar 

  162. Rosner, F., Valmont, I., Kozinn, P.J., Caroline, L.: Leukocyte function in patients with leukemia. Cancer25, 835 (1970)

    Google Scholar 

  163. Rosner, F., Kozinn, P.J., Jervis, G.A.: Leukocyte function and serum immunoglobulins in Down's syndrome. New York State J. of Med.73, 1 (1973)

    Google Scholar 

  164. Sato, A., Yoshimatsa, S.: The peroxidase reaction in epidemic encephalitis. A new diagnostic and prognostic method. Amer. J. Dis. Child29, 301 (1925)

    Google Scholar 

  165. Seebach, G., Eschenbach, C.: Zur Entstehung cytoplasmatischer Vakuolen von Leukocyten im in-vitro-Versuch. I. Bildung cytoplasmatischer Vakuolen in Abhängigkeit von Entzündungsprozessen. Klin. Wschr.52, 678 (1974)

    Google Scholar 

  166. Seth, V., Chandra, R.K.: Opsonic activity, phagocytosis, and bactericidal capacity of polymorphs in undernutrition. Arch. Dis. Childhood47, 282 (1972)

    Google Scholar 

  167. Smith, C.W., Hollers, J.C., Dupree, E., Goldman, A.S., Lord, R.A.: A serum inhibition of leukotaxis in a child with recurrent infections. J. Lab. Clin. Med.79, 878 (1972)

    Google Scholar 

  168. Solberg, C.O.: Influence of phenylbutazone on the phagocytic and bactericidal activities of neutrophil granulocytes. Acta path. microbiol. scand. Sect.82, 258 (1974)

    Google Scholar 

  169. Soriano, R.B., South, M.A., Goldman, A.S., Smith, C.W.: Defect of neutrophil mobility in a child with recurrent bacterial infections and disseminated cytomegalovirus infection. J. of Pediat.83, 951 (1973)

    Google Scholar 

  170. Spitznagel, J.K.: Sorting out lysosomes and other cytoplasmic granules from polymorphs of rabbits and humans: A search for antibacterial factors. In: R.C. Williams and H.H. Fudenberg (Ed.) Phagocytic mechanism in Health and Disease. Thieme Stuttgart 83 (1972)

    Google Scholar 

  171. Steerman, R.L., Synderman, R., Leikin, S.L., Colten, H.R.: Intrinsic defect of the polymorphnuclear leukocyte resulting in impaired chemotaxis and phagocytosis. Clin. Exp. Immunol.9, 939 (1971)

    Google Scholar 

  172. Stossel, T.P., Root, R.H., Vaughan, M.: Phagocytosis in chronic granulomatous disease and the Chediak-Higashi syndrome. New Engl. J. Med.286, 120 (1972)

    Google Scholar 

  173. Strauss, R.R., Paul, B.B., Sharra, A.J.: Effect of phenylbutazone on phagocytosis and intracellular killing by guinea pig polymorphnuclear leukocytes. J. Bact.96, 1982 (1968)

    Google Scholar 

  174. Strauss, R.G., Bove, K.E., Jones, J.F., Mauer, A.M., Fulginiti, V.A.: An anomaly of neutrophil morphology with impaired function. New Engl. J. of Med.290, 478 (1974)

    Google Scholar 

  175. Truckenbrodt, H., Schwenk, H.U.: Die septische Granulomatose, eine Funktionsstörung der segmentkernigen Leukozyten. Arch. f. Kinderhk.183, 299 (1972)

    Google Scholar 

  176. Undritz, E.: Die Alius-Grignaschi-Anomalie. Der erbliche konstitutionelle Peroxydasedefekt der Neutrophilen und Monozyten. Blut14, 129 (1966)

    Google Scholar 

  177. Ward, P.A.: The chemosuppression of chemotaxis. J. Exp. Med.124, 209 (1966)

    Google Scholar 

  178. Ward, P.A.: Leukotactic factors in health and disease. Am. J. Pathol.64, 521 (1971)

    Google Scholar 

  179. Ward, P.A., Becker, E.L.: Mechanisms of the inhibition of chemotaxis by phosphane ester. J. Exp. Med.125, 1001 (1967)

    Google Scholar 

  180. Ward, P.A., Lepou, I.H., Newman, L.J.: Bacterial factors chemotactic for polymorphnuclear leucocytes. Am. J. Path.52, 725 (1968)

    Google Scholar 

  181. Ward, P.A., Schlegel, R.: Defective leukotaxis in a child with recurrent infections. LancetII, 344 (1969)

    Google Scholar 

  182. Ward, P.A., Hill, J.H.: C5-chemotactic fragments produced by an enzyme in liposomal granules of neutrophils. J. Immun.104, 535 (1970)

    Google Scholar 

  183. Ward, P.A., Hill, J.H.: Role of complement in the generation of leukocytic mediators in immunologic and nospecific tissue injuries. In: Immunopathology of inflammation. Ed.: B.K. Forscher, J.C. Houck, Excerpta Medica Amsterdam 1971

    Google Scholar 

  184. Warden, G.D., Mason, A.D., Pruitt, B.A.: Evaluation of leukocyte chemotaxis in vitro in thermally injured patients. J. of Clin. Invest.54, 1001 (1974)

    Google Scholar 

  185. Weissman, G.: Lysosomes. Blood24, 594 (1964)

    Google Scholar 

  186. Weissman, G., Dukon, P., Zurier, R.B.: Effect of cyclic AMP on release of lysosomal enzymes from phagocytes. Nature (Lond.) New Biol.231, 131 (1971)

    Google Scholar 

  187. White, J.G.: The Chediak-Higashi syndrome: A possible lysosomal disease. Blood28, 143 (1966)

    Google Scholar 

  188. White, L.R., Jannetta, A., Kaplan, E.L., Davis, S.D., Wedgwood, R.J.: Leukocytes in Job's syndrome. LancetI, 630 (1969)

    Google Scholar 

  189. Williams, R.C., Jr.: Opsonins in phagocytosis. In: Phagocytic mechanisms in Health and Disease (Ed. R.C. Williams, Jr. and H.H. Fudenberg) Thieme Stuttgart 167 (1972)

    Google Scholar 

  190. Windhorst, D.B.: Studies on a hereditary defect involving lysosomal structure. Fed. Proc.25, 358 (1966)

    Google Scholar 

  191. Windhorst, D.B., Page, A.R., Holmes, B., Quie, P.G., Good, R.A.: The pattern of genetic transmission of the leukocyte defect in fatal granulomatous disease of childhood. J. Clin. Invest.47, 1026 (1968)

    Google Scholar 

  192. Winkelstein, J.A., Drachman, R.H.: Deficiency of pneumococal serum opsonizing activity in sickle cell disease. N. Engl. J. Med.279, 459 (1968)

    Google Scholar 

  193. Wood, W.B., Jr.: Studies on the cellular immunology of acute bacterial infections. Harvey Lectures47, 72 (1951)

    Google Scholar 

  194. Zucker-Franklin, D.: The phagosomes in rheumatoid synovial fluid leukocytes: A light, fluorescence and electron microscope study. Arthritis Rheum.9, 24 (1966)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Niethammer, D., Wildfeuer, A., Kleihauer, E. et al. Granulocytendysfunktion. Klin Wochenschr 53, 739–746 (1975). https://doi.org/10.1007/BF01614854

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01614854

Key words

Schlüsselwörter

Navigation