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Immune reactions of platelets and their clinical significance

Immunreaktionen von Thrombocyten und ihre klinische Bedeutung

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Zusammenfassung

Aufgrund der Besonderheiten der Thrombocytenmembran mit genetisch determinierten, immunogenen Merkmalen einerseits und hämostatischen Funktionen andererseits nehmen Blutplättchen an Immunreaktionen nicht nur passiv als Zielzelle, sondern auch aktiv als Funktionszelle teil. Es wird eine Übersicht über tierexperimentelle Befunde und Ergebnisse von bisher vorliegenden in vivo- und in vitro-Untersuchungen mit menschlichen Blutplättchen gegeben und die Bedeutung thrombocytärer Immunreaktionen für die Pathogenese von hämorrhagischen Diathesen erörtert.

Summary

It is recognized that blood plaetelets with a peculiar cell membrane which carries numerous genetically determined immunogens, but is also intricately associated with the hemostatic process not only participate in immune reactions as a passive target cell, but also as an active functional cell. Pertinent results of animal experiments and of in vivo and in vitro investigations with human blood platelets are reviewed in the attempt to elucidate the role of immune reactions of platelets in the pathogenesis of various human bleeding disorders.

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  1. Abteilung Klinische Immunologie und Transfusionsmedizin der Justus Liebig-Universität Gießen, Germany

    Ch. Mueller-Eckhardt

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The author's investigations were supported by the Deutsche Forschungsgemeinschaft (Mu 277/1, 2, 3, 5).

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Mueller-Eckhardt, C. Immune reactions of platelets and their clinical significance. Klin Wochenschr 53, 889–897 (1975). https://doi.org/10.1007/BF01468980

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