Zusammenfassung
Die Monocyten von 7 Patienten mit fortgeschrittenem M. Hodgkin (Stadium III und IV) und von 2 Patienten mit generalisiertem Lymphosarcom zeigten eine hoch signifikant verminderte Phagocytose von IgG-beladenen Erythrocyten, unabhängig davon, ob eine Therapie bereits durchgeführt war oder nicht. Demgegenüber war die Phagocytose-Aktivität bei 3 Patienten mit M. Hodgkin, Stadium II und einem mit Lymphosarkom in Vollremission eher gegenüber der Norm gesteigert. Die Reduktion von Nitroblau-Tetrazolium durch Monocyten war bei allen untersuchten Patienten im Vergleich zu Normalpersonen im Mittel signifikant gesteigert, obwohl nur ein Patient zum Zeitpunkt der Untersuchung einen gesicherten bakteriellen Infekt aufwies. Die mögliche Bedeutung dieser Befunde für die bei diesen Erkrankungen bestehenden Immundefekte wird diskutiert.
Summary
The monocytes of 7 patients with advanced Hodgkin disease (stages III and IV) and of two patients with generalized lymphosarcoma exhibited a highly significant impairment of the phagocytosis of IgG-coated red cells, regardless of receiving therapy or not. In contrast three patients with M. Hodgkin, stage II B, and one with lymphorsarcoma in complete remission showed a rather elevated monocyte phagocytic activity. The nitroblue tetrazolium reduction by monocytes in the mean was significantly enhanced in all patients investigated, compared with normal persons, although only in one patient a bacterial infection was apparent at the time of the test. The possible implication of the findings in the well known immunodeficiency present in M. Hodgkin and lymphosarcoma is discussed.
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Urbanitz, D., Fechner, I. & Gross, R. Reduced monocyte phagocytosis in patients with advanced Hodgkin's disease and lymphosarcoma. Klin Wochenschr 53, 437–440 (1975). https://doi.org/10.1007/BF01493369
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DOI: https://doi.org/10.1007/BF01493369