Summary
Immunoreactive parathyroid hormone (iPTH) and 25-hydroxycalciferol (25(OH)D) serum levels were determined in 32 patients with renal osteopathy, they were correlated with the results of bone biopsy and other clinical parameters. iPTH was closely related to bone histology, it did not correspond to serum calcium and alkaline phosphatase, but the correlation to serum phosphate was statistically significant. 25(OH)D levels were not related to the histological findings of osteomalacia or increased bone resorption, while a correlation between the vitamin D metabolite and serum calcium could be observed. Since iPTH and 25(OH)D levels exhibited a significant correlation, an inhibitory effect of 25(OH)D on parathyroid gland function in renal failure was discussed.
Zusammenfassung
Bei 32 Patienten mit renaler Osteopathie wurden die Serumspiegel des immunoreaktiven Parathormons (iPTH) und des 25-Hydroxycalciferol (25(OH)D) bestimmt und mit den Ergebnissen der Knochenbiopsie und anderen klinischen Parametern korreliert. Das iPTH entsprach den Ergebnissen der Knochenhistologie, zeigte jedoch keine Beziehung zum Serumcalcium und der alkalischen Phosphatase, während eine statistisch signifikante Korrelation mit dem Serumphosphat bestand. Die 25(OH)D-Spiegel verhielten sich unabhängig vom histologischen Nachweis einer Osteomalazie oder vermehrter Knochenresorption, es fand sich eine Beziehung zwischen dem Vitamin-D-Metaboliten und dem Serumcalcium. Da die iPTH- und die 25(OH)D-Spiegel eine signifikante inverse Korrelation zeigten, wurde ein inhibitorischer Effekt des 25(OH)D auf die Nebenschilddrüsenfunktion bei Niereninsuffizienz diskutiert.
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Mit Unterstützung der Deutschen Forschungsgemeinschaft1 und des SFB 34 „Endokrinologie“ (Hamburg) der Deutschen Forschungsgemeinschaft2
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Offermann, G., Schaefer, K., Schulz, A. et al. Immunoreaktives Parathormon, 25-Hydroxycalciferol und Knochenhistologie bei renaler Osteopathie. Klin Wochenschr 54, 625–632 (1976). https://doi.org/10.1007/BF01469028
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DOI: https://doi.org/10.1007/BF01469028