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Beeinflussung von Blutgerinnung und Fibrinolyse durch Oestrogen, Gestagen und eine Oestrogen-Gestagen-Kombination

Blood coagulation and fibrinolysis in women receiving estrogen, gestagen and estrogen-gestagen-contraceptives

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Summary

Eight female subjects received a contraceptive with a low estrogen content (Neogynon®), the estrogen component (50 µg ethinylestradiol) and consecutively the gestagen component (250 µg D-Norgestrel) of the contraceptive.

Each treatment cycle was followed by a control cycle. At various times of the control and therapy cycles several coagulation and fibrinolytic parameters were investigated. Statistical analyses were performed by multivariate two-factorial analysis of variance. Plasminogen exhibited a statistically significant increase during the treatment with ethinylestradiol and the combination of this steroid with D-norgestrel. No significant changes were found for all other parameters, including partial thromboplastin time, fibrinogen, factors X, IX, VIII, factor VIII-related antigen, antithrombin III and fibrin(ogen)degradation products.

Zusammenfassung

Bei 8 Probandinnen wurde in zeitlicher Aufeinanderfolge ein Kontrazeptivum mit niedrigem Oestrogengehalt (Neogynon®), sowie die Oestrogenkomponente (50 µg Äthinylöstradiol) und die Gestagenkomponente (250 µg D-Norgestrel) des Kombinationspräparates verabreicht. Zwischen den einzelnen Medikationszyklen wurden Kontrollzyklen eingeschaltet. Zu mehreren Zeitpunkten während der Medikationszyklen und Kontrollzyklen wurden verschiedene Parameter des Gerinnungs- und Fibrinolysesystems untersucht. Zur statistischen Auswertung wurden multivariate zweifaktorielle Varianzanalysen durchgeführt. Es ergab sich, daß Plasminogen während des Neogynon- und Oestrogenzyklus einen signifikanten Anstieg zeigte, während alle übrigen untersuchten Parameter [PTT, Fibrinogen, Faktor X, Faktor IX, Faktor VIII (biologisch und immunologisch), Antithrombin III und Fibrin(ogen)spaltprodukte] keine signifikanten Veränderungen erkennen ließen.

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Authors and Affiliations

  1. I. Medizinische Klinik der Universität Wien, Austria

    K. Lechner, E. Hartmann, W. H. F. Schneider, J. Spona & K. Matt

  2. Universitäts-Frauenklinik Wien, Austria

    K. Lechner, E. Hartmann, W. H. F. Schneider, J. Spona & K. Matt

  3. Schering AG Berlin, Fachbereich Physikochemie und Informatik, Germany

    K. Lechner, E. Hartmann, W. H. F. Schneider, J. Spona & K. Matt

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  1. K. Lechner
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Lechner, K., Hartmann, E., Schneider, W.H.F. et al. Beeinflussung von Blutgerinnung und Fibrinolyse durch Oestrogen, Gestagen und eine Oestrogen-Gestagen-Kombination. Klin Wochenschr 54, 431–438 (1976). https://doi.org/10.1007/BF01470929

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