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Lipoproteinveränderungen unter Clofibrat bei Typ IV-Hyperlipoproteinämien

Effect of clofibrate on lipoprotein-lipids in patients with type IV hyperlipoproteinaemia

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Summary

The effect of clofibrate treatment (1.5 g/day for four weeks) on triglycerides, cholesterol and phospholipids in very low density lipoproteins (VLDL), low density lipoproteins (LDL) and high density lipoproteins (HDL) was investigated in 12 patients with type IV hyperlipoproteinaemia. The decrease of serum triglycerides was due to the reduction of VLDL-triglycerides. Furthermore, LDL-hypertriglyceridemia was normalised by clofibrate. — There existed a significant decrease of VLDL- und HDL-cholesterol as well as of VLDL-phospholipids.

The changes in LDL-cholesterol and LDL-phospholipids by clofibrate depended on their initial concentrations which were negatively correlated to the serum triglycerides before treatment. — The normalisation of lipid concentrations in VLDL and LDI could be explained by a stimulated delipidation of the apo B-lipoproteins.

Zusammenfassung

Der Einfluß einer vierwöchigen Clofibratbehandlung auf den Triglycerid-, Cholesterin-und Phospholipidgehalt von Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL) und High Density Lipoproteins (HDL) wurde bei 12 Patienten mit primärer Typ IV-Hyperlipoproteinämie untersucht. Die Senkung der Serumtriglyceride war durch einen Abfall der VLDL-Triglyceride bedingt. Darüber hinaus kam es zu einer Normalisierung der zum Teil nachweisbaren LDL-Hypertriglyceridämie. — Die Cholesterinkonzentration nahm in den VLDL und HDL, der Phospholipidgehalt nur in den VLDL signifikant ab. In den LDL änderten sich diese beiden Lipide in Abhängigkeit von ihren Ausgangswerten, die negativ mit den Serumtriglyceridkonzentrationen korrelierten. Die Normalisierung von VLDL- und LDL-Lipiden könnte mit einer beschleunigten Delipidation der Apo-B-Lipoproteine erklärt werden.

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  1. Medizinische Klinik II, Klinikum Großhadern, der Universität München, Germany

    P. Weisweiler & P. Schwandt

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  1. P. Weisweiler
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  2. P. Schwandt
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Weisweiler, P., Schwandt, P. Lipoproteinveränderungen unter Clofibrat bei Typ IV-Hyperlipoproteinämien. Klin Wochenschr 55, 791–794 (1977). https://doi.org/10.1007/BF01651267

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